lps

  1. haidut

    Endotoxin (LPS) may drive kidney damage in diabetes type II

    Not much of a news, but I like adding to the, already big, pile of evidence that endotoxin/LPS is a major causal factor in virtually all chronic conditions that continue to mystify medicine. Since the study below mentions the compromised intestinal barrier in diabetes patients, interventions...
    • haidut
    • Thread
    • ckd diabetes endotoxin gut barrier kidney damage lps microalbumineria tlr4
    • Replies: 3
    • Forum: Scientific Studies
  2. cs3000

    TDCA bile acid protects gut against lipopolysaccharide (LPS) endotoxin from bacteria

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904360/ "Dietary TDCA supplementation alleviates mucosal damage and improves survival after LPS-induced intestinal injury. Taurodeoxycholic acid is protective of the intestinal mucosa by increasing resistance to injury-induced apoptosis...
    • cs3000
    • Thread
    • bacteria bile acid endotoxin gut lps tdca
    • Replies: 1
    • Forum: Digestion
  3. haidut

    Another "paradox" - glucocorticoids cause inflammation, insulin blocks it

    As many of my readers know, I am not a fan of the ubiquitous usage of both bioidentical and synthetic glucocorticoids (GC) in medicine. Once used only in the most severe cases, some form of GC therapy awaits virtually all patients in a hospital (regardless of condition), and doctors are now...
    • haidut
    • Thread
    • cortisol endotoxin glucocorticoid inflammation insulin lps tlr tlr4
    • Replies: 4
    • Forum: Scientific Studies
  4. haidut

    Endotoxin (LPS) causes Alzheimer Disease (AD)

    I have made posts on this topic in the past, but it seems this most recent study directly states that endotoxin/LPS is a major cause of AD. All other studies have been either animal models or did not directly implicate LPS. The study below claims to be the first that integrates all available...
    • haidut
    • Thread
    • alzheimer dementia endotoxin fiber inflammation lps tlr4
    • Replies: 6
    • Forum: Scientific Studies
  5. haidut

    Blocking endotoxin may reverse cognitive decline of aging

    Another study implicating endotoxin (LPS) and its associated receptor (TLR4) in a phenotype of aging considered "normal" by mainstream medicine, though it almost universally progresses into dementia territory with advancing age, to the point where 90%+ of people over 85 have at least moderate...
    • haidut
    • Thread
    • brain cognitive dementia endotoxin inflammation lps memory tlr4
    • Replies: 5
    • Forum: Scientific Studies
  6. haidut

    Endotoxin (LPS) drives obesity, diabetes and CVD in young people

    It looks like medicine is starting to change course on its attitude to endotoxin (LPS). After claiming that LPS is not an issue at all for any human with a functioning liver, a number of high profile studies have come out recently demonstrating chronic endotoxemia (even low-grade) is a causal...
  7. Mauritio

    Doxycycline for liver health

    Doxycycline is beeing increasingly studied for its anti-inflammatory effects at sub-antimicrobial doses. This study shows how and that it might be helpful in avoiding liver scarring/fibrosis. It shows that MMP-8, which is released in response to LPS, activates the hepatic stellate cells...
  8. haidut

    Cancer cells deprive immune cells of energy by devouring their mitochondria

    In a description that could be a good plot for a horror-movie, the study below demonstrates that the immune failure often seen in cancer is, again, bioenergetic in origin. More specifically, the immune system cells are getting literally the energy (i.e. mitochondria) sucked out of them by cancer...
    • haidut
    • Thread
    • cancer cell endotoxin estrogen immune invadopodia lps mitochondria oxphos phagocytosis
    • Replies: 1
    • Forum: Scientific Studies
  9. A

    The homeoviscous adaptation to dietary lipids (HADL) model explains controversies over saturated fat, cholesterol, and cardiovascular disease risk

    SFAs play the leading role in 1 of the greatest controversies in nutrition science. Relative to PUFAs, SFAs generally increase circulating concentrations of LDL cholesterol, a risk factor for atherosclerotic cardiovascular disease (ASCVD). However, the purpose of regulatory mechanisms that...
  10. haidut

    Endotoxin (LPS) may directly cause cancerization of normal cells

    A very interesting new study, which confirms the direct causal role LPS has in chronic inflammatory diseases, and especially in cancer. In addition, the study may answer one of the long-standing critiques the medical establishment has always had against the hypothesis that LPS causes cancer (and...
    • haidut
    • Thread
    • cancer cancerization chronic endotoxin inflammation low-grade lps tlr4
    • Replies: 2
    • Forum: Scientific Studies
  11. haidut

    PUFA required for periodontal disease, aspirin may help

    It is common knowledge even among mainstream dentists that periodontal disease is caused by bacteria accumulating under the gums, which over time leads to chronic inflammation and thus destruction of both gum tissue and the alveolar/jaw bone underneath the gums. Another "new" discover is that...
    • haidut
    • Thread
    • aspirin endotoxin inflammation lps peridontitis periodontal pge2 prostaglandin pufa
    • Replies: 25
    • Forum: Scientific Studies
  12. haidut

    Endotoxin (LPS) causes rheumatoid arthritis...and COVID-19

    A great new study, which is perhaps the first to directly point the finger at endotoxin as perhaps the main cause of rheumatoid arthritis (RA). RA is an "autoimmune" condition and not only shares symptoms with other similar conditions such as Lupus, psoriasis, MS, etc, but now all of them are...
    • haidut
    • Thread
    • autoimmune covid-19 endotoxin lps microbiome rheumatoid arthritis tlr4
    • Replies: 14
    • Forum: Scientific Studies
  13. haidut

    Endotoxin (LPS) as a cause of liver disease, obesity and diabetes

    The first article below is actually about praising fermented foods, which I don't really agree with. So, I am posting it mostly because of the quote on endotoxin/LPS, which is a very rare finding in published medical literature since medicine does not recognize chronic, low-grade endotoxemia as...
    • haidut
    • Thread
    • diabetes endotoxin hdl hepatitis liver disease lps obesity tlr4
    • Replies: 17
    • Forum: Scientific Studies
  14. haidut

    Blocking the endotoxin receptor (TLR4) may prevent / treat hearing loss

    I did a post a few months ago on the connection between tinnitus and serotonin - i.e. using anti-serotonin drugs may treat tinnitus. Since tinnitus is almost always a precursor state to hearing loss (and eventually deafness), the two conditions obviously go hand-in-hand and are likely caused by...
    • haidut
    • Thread
    • 5-ht deafness endotoxin hearing loss inflammation lps tinnitus tlr4
    • Replies: 8
    • Forum: Scientific Studies
  15. haidut

    Endotoxin (LPS) may be the cause of fatal lung damage in COVID-19

    Yet another study, which demonstrates that there is virtually no disease (acute of chronic, infections or not) where the infamous LPS does not play a causative role. As it turns out, the often fatal inflammatory reaction (cytokine storm) that usually kills patients with COVID-19 in ICU, is...
    • haidut
    • Thread
    • covid-19 endotoxin iatrogenic inflammation lps lung damage mortality tlr4
    • Replies: 0
    • Forum: Scientific Studies
  16. haidut

    Silica, present in most supplements/food, activates the endotoxin receptor (TLR4)

    Many of my readers know about the health risks of silica - a substance doctors and pundits call completely "benign, present in virtually all commercially sold dietary supplements and also in most commercially sold food (even organic ones!). The most commonly used form commercially is silicon...
    • haidut
    • Thread
    • bones endotoxin inflammation lps lung silica silicon dioxide tlr4
    • Replies: 78
    • Forum: Scientific Studies
  17. shine

    L. plantarum protects testicles & lowers inflammation/endotoxin

    It is well known that phtalates used in plastics are endocrine disruptors and damage testicular tissue. This study is showing that Lactobacillus plantarum (LP) alleviates testicular damage, increases testosterone back to normal levels, lowers inflammatory mediators like TNF-a, IL-1b and IL-6 and...
    • shine
    • Thread
    • damage disruptors endocrine endotoxin inflammation lactobacillus lps plantarum testicular testosterone
    • Replies: 1
    • Forum: Hormones
  18. Ismail

    Endotoxin (LPS) drives CD38 expression and therefore seems to effect NAD levels

    How To Inhibit CD38 As We Age | LPS Drives CD38 Expression | Prof Covarrubias Interview Series Ep5
  19. haidut

    Endotoxin (LPS) as a cause of systemic inflammation seen in obesity

    Yet another study implicating the great villain of systemic health - endotoxin / LPS. It is well-known that most people with obesity have high levels of inflammatory biomarkers both in their tissues and bloodstream. The study below demonstrates that the inflammation seen in adipose tissue of...
  20. haidut

    Endotoxin behind the mortality of Black Death and 1918 Flu pandemics

    As many of my readers know, many/most people dying from COVID-19 develop either sepsis and/or respiratory failure. Endotoxin (LPS) is now a known cause behind both of these conditions, as a virus by itself has no known mechanism of causing a cytokine storm. As much as I revile the term...
    • haidut
    • Thread
    • 1918 flu black death cytokine storm endotoxin lps mortality plague
    • Replies: 3
    • Forum: Scientific Studies
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