lox

  1. haidut

    PUFA metabolites may drive bacterial infections and their resistance to antibiotics

    The study below demonstrates yet again that there is hardly an aspect of human health that PUFA does not influence in a detrimental manner, even seemingly non-metabolic aspects such as bacterial infections. As it turns out, most bacteria express the enzyme family known as lipoxygenases (LOX) and...
  2. haidut

    PUFA (metabolites) Drive Heart Failure And Possibly Diabetes

    Over the years I have posted a number of studies on the roles of PUFA metabolites such as prostaglandins and leukotrienes in many chronic conditions including cancer, Alzheimer, Parkinson, ALS, MS, CVD, etc. For those that are new to this issue, COX enzymes are responsible for prostaglandin...
  3. haidut

    Inhibition Of PUFA Metabolism (LOX) Trigger Immediate Apoptosis In Prostate Cancer

    These studies show that PUFA has both direct (linoleic) and secondary (through LOX) stimulating effect on prostate cancer growth, independently of any hormones. Inhibiting the LOX-5 pathway led to immediate growth arrest and apoptosis of prostate cancer cells. The important message for both...
  4. haidut

    Blocking PUFA Metabolism May Reverse Alzheimer Disease (AD)

    I posted a few studied showing PUFA and its metabolites are strongly involved in AD and brain aging in general. Increased Pufa Oxidation May Be Biomarker For Alzheimers Blocking Inflammation From PUFA Reverses Brain Aging The second link above discussed specifically the inhibition of the...
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