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lox

  1. haidut

    Higher PUFA intake correlated with mental disease

    An epidemiological study, yet still useful IMO since the correlation was maintained across the various levels of PUFA intake - i.e. the higher the PUFA intake the higher the prevalence of a mental disorder such as depression, which suggests a causal link. The link was the strongest in males and...
    • haidut
    • Thread
    • cox depression fat inflammation leukotriene linoleic lox mental disease prostaglandin pufa
    • Replies: 6
    • Forum: Scientific Studies
  2. haidut

    Blocking PUFA metabolism therapeutic for Multiple Sclerosis (MS)

    The rates of MS have been steadily rising over the last several decades. While mainstream medicine claims the cause is "unknown", it is well known that it has an almost perfect inverse association with sunshine exposure, vitamin D levels, aspirin usage, histamine blockers, etc. This suggest an...
    • haidut
    • Thread
    • autoimmune inflammation leukotriene lipoxygenase lox multiple sclerosis pufa
    • Replies: 3
    • Forum: Scientific Studies
  3. haidut

    PUFA metabolites may drive bacterial infections and their resistance to antibiotics

    The study below demonstrates yet again that there is hardly an aspect of human health that PUFA does not influence in a detrimental manner, even seemingly non-metabolic aspects such as bacterial infections. As it turns out, most bacteria express the enzyme family known as lipoxygenases (LOX) and...
    • haidut
    • Thread
    • antibiotic bacteria efa infection lipoxigenase lox pufa resistance
    • Replies: 0
    • Forum: Scientific Studies
  4. haidut

    PUFA (metabolites) Drive Heart Failure And Possibly Diabetes

    Over the years I have posted a number of studies on the roles of PUFA metabolites such as prostaglandins and leukotrienes in many chronic conditions including cancer, Alzheimer, Parkinson, ALS, MS, CVD, etc. For those that are new to this issue, COX enzymes are responsible for prostaglandin...
    • haidut
    • Thread
    • 12/15lox alox15 cause cvd diabetes drive fibrosis heart attack heart failure inflammation lipoxygenase lox pufa
    • Replies: 4
    • Forum: Scientific Studies
  5. haidut

    Inhibition Of PUFA Metabolism (LOX) Trigger Immediate Apoptosis In Prostate Cancer

    These studies show that PUFA has both direct (linoleic) and secondary (through LOX) stimulating effect on prostate cancer growth, independently of any hormones. Inhibiting the LOX-5 pathway led to immediate growth arrest and apoptosis of prostate cancer cells. The important message for both...
    • haidut
    • Thread
    • apoptosis arachidonic growth immediate linoleic lox prostate cancer pufa
    • Replies: 18
    • Forum: Scientific Studies
  6. haidut

    Blocking PUFA Metabolism May Reverse Alzheimer Disease (AD)

    I posted a few studied showing PUFA and its metabolites are strongly involved in AD and brain aging in general. Increased Pufa Oxidation May Be Biomarker For Alzheimers Blocking Inflammation From PUFA Reverses Brain Aging The second link above discussed specifically the inhibition of the...
    • haidut
    • Thread
    • alox15 alzheimer's brain inflammation inhibitor leukotrienes lipoxygenase lox
    • Replies: 11
    • Forum: Scientific Studies
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