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lowering

  1. C

    11b-HSD1 inhibitors don't lower cortisol levels? increased ACTH response

    a lot of people try to lower cortisol this way. But these studies with a 11b-hsd1 inhibitor given to humans shows plasma cortisol levels stay the same regardless and ACTH levels rise. (ACTH rises in response to the lower conversion of cortisone -> cortisol from the enzyme inhibition, so with...
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