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lipolysis

  1. haidut

    A single, low dose niacinamide drops triglycerides by 75%

    Among the vitamin B3 analogs, niacin is perhaps the most famous for its ability to both raise "good" cholesterol (HDL) and also lower triglycerides. However, niacinamide, nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) are all effective precursors to NAD (as niacin is) and...
  2. haidut

    Lipolysis preferentially releases PUFA from adipose tissue

    ...compared to SFA and/or MUFA. This topic is considered highly controversial in Peat-land, mostly because of the dearth of studies dealing with it. I must have received hundreds of emails at this point criticizing Peat's stance on this issue and claiming that there is no evidence for...
  3. haidut

    High blood PUFA "a specific feature of severe COVID-19 pneumonia"

    The evidence for PUFA being a crucial pathological factor in yet another disease is probably not surprising to my readers. The reason I like this study is that since COVID-19 is still (unfortunately) the main topic of the day in most Western countries, a study discussing PUFA in a COVID-19...
  4. haidut

    Inhibiting lipolysis may treat diabetes

    Probably nothing surprising to my readers, but I think the study below is still important as it is one of the very few that openly state that diabetes is driven not by genetics but by excessive free fatty acids in the blood. While it does not mention it directly, the study is a great...
  5. A

    Why Cancer of the Heart is So Rare

    https://raypeatforum.com/community/threads/cancer-cells-addicted-to-fat-and-use-fat-oxidation-for-survival.7639 https://raypeatforum.com/community/threads/forcing-the-heart-to-burn-glucose-instead-of-fat-may-cure-heart-failure.33094 Dr. Stephen Hussey To understand why cancer in the heart is...
  6. A

    Link Between Spinal Muscular Atrophy and Fatty Acid Metabolism

    Spinal muscular atrophy (SMA) is an autosomal recessive condition that results in pathological deficiency of the survival motor neuron (SMN) protein. SMA most frequently presents itself within the first few months of life and is characterized by progressive muscle weakness. As a neuromuscular...
  7. haidut

    How lipolysis may damage organs such as the heart

    It is well-known in endocrinology, and especially among doctors specializing in diabetes, that excessive lipolysis is highly detrimental not only for the overall progression of metabolic diseases like diabetes, but also for most of the organs of the patient. Lipolysis is known to be elevated in...
  8. D

    OEA, maybe my favorite supplement?

    Recently I started taking Oleoylethanolamide or OEA from science.bio. This ***t is life changing. A supplement you can truly feel. It acts on the endocannabinoid system and is very similar to anandamide. I feel euphoria, relaxation, and just overall happiness and well being when I take it...
  9. haidut

    Stress-driven lipid peroxidation, inflammation re-awakens dormant cancer cells

    Yet another study demonstrating that stress is anything but benign or irrelevant for chronic diseases, especially for cancer. The study below demonstrates that stress-induced increases of epinephrine and norepinephrine results in increased lipolysis and a cascade of pro-carcinogenic downstream...
  10. haidut

    Keto Diet Can Cause Lethal Kidney Failure

    The bad news for the low-carb diets just keep piling on. This case report is about a young and (presumably) healthy Indian actress, which quickly deteriorated and eventually died of kidney failure while subjecting herself to the keto diet. Before the hate mail starts pouring into my mailbox...
  11. haidut

    PUFA Exacerbate, Saturated Fats (SFA) / Albumin / Calcium Ameliorate COVID-19

    A few months ago I posted about a study discussing the role of lipid peroxidation in the COVID-19 pathology. While that study did not make any statements about effects of diet on the disease course/outcome, it did suggest lipid peroxidation blockers such as vitamin E would be therapeutic. Now...
  12. haidut

    Lipolysis / FFA Drive Breast Cancer By Promoting Estrogen Signalling

    The evidence for the fat-loving nature of cancer just keeps on accumulating. During the last podcast with Danny and Ray, I mentioned that in cancer cells the enzyme fatty acid synthase (FAS) is actually part of the estrogen receptor (ER) complex. As such, anything that increases the...
  13. haidut

    SFA / MUFA Are Preferentially Oxidized, While PUFA Are Stored/accumulated

    Just a quick post in response to some of the hate mail I keep getting on a daily basis in regards to the body's discriminatory treatment of various fat types. According to various proponents of keto diets, fasting, etc the organism has no preference for one type of fat or another in terms of...
  14. haidut

    Stress (epinephrine And Lactate) Cause Tumor Growth, Vitamin C Stops It

    Yet another study linking chronic stress to cancer growth. I posted several threads in the past demonstrating the negative effects epinephrine and lipolysis on cancer cell growth and how administering a beta blocker can inhibit the growth of tumors. Stress (adrenaline, Noradrenaline) As The Main...
  15. haidut

    Fatty Acid Oxidation (FAO) Makes Cancer Therapy-resistant, Niacinamide May Help

    Yet another study that shows FAO playing a crucial role in cancer progression. As many forum users know, anti-angiogenic therapies are one of the cornerstones of current cancer treatments. This therapy typically uses the so-called VEGF inhibitors to block the formation of new blood vessels in...
  16. haidut

    Stress (adrenaline, Noradrenaline) As The Main Driver Of Cancer Metastases

    I just posted a study in which it was shown that surgical removal of a tumor results in massive and uncontrolled formation of metastases across the entire organism. Universal Test For Cancer Progression/stage Here is the quote again, just to make the point of this thread clear. "...The...
  17. haidut

    Cancer Is A State Of Chronic Stress With Elevated Lipolysis And Ketogenesis

    I am posting this study because it invalidates one of the central dogmas of modern oncology - i.e. that cancer is a localized, organ-specific disease that is best handled by attacking/destroying/removing the affected organ/tissue. Most doctors would flatly deny/reject the statement that a cancer...
  18. haidut

    Inhibiting Lipolysis May Treat / Cure Cancer

    I posted a number of threads over the last 6 months that show cancer's appetite for fat and how inhibiting fatty acid oxidation or transport into the cell can have dramatic therapeutic results even for highly lethal malignancies like pancreatic cancer. Triple-Negative Breast Cancers Depend On...
  19. P

    Manganese Mimics Insulin

    -manganese increases co2 production from glucose -inhibits lipolysis -increases lipogenesis Regulation of glucose utilization and lipogenesis in adipose tissue of diabetic and fat fed animals: effects of insulin and manganese. - PubMed - NCBI
  20. Hugh Johnson

    Indomethacin But Not Aspirin Inhibits Basal And Stimulated Lipolysis In Rabbit Kidney

    http://www.ncbi.nlm.nih.gov/pubmed/7465862
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