1. Mauritio

    T3 increases klotho, reduces lipofuscin and oxidative stress

    Most people probably heard of the gene klotho by now. Overexpression of klotho in mice leads to an increase in health and life expectancy. Peat has also spoken favorably about it : View: I have previously posted about anti-aging benefits of T3 : -...
  2. haidut

    PUFA, not sugar, causes eye damage associated with diabetes/aging

    An amazing pair of new studies that coincidentally (synchronicity!) came out at the same time, but without the authors seemingly knowing each other or citing each other's work. One of the studies dispels the ubiquitous myth that high blood glucose is what causes eye damage, especially in...
  3. haidut

    Aspirin / eugenol can remove lipofuscin from cells

    One of the visible hallmarks of aging is the accumulation of so-called "age pigment" or "aging spots", commonly known in scientific circles as lipofuscin. The latter is a complex mix of peroxidized polyunsaturated fats (PUFA) and various metals (especially iron) that accumulates in cells with...
  4. haidut

    Iron drives heart failure by fattening the heart; iron chelators may prevent/cure

    Recommending high intake of iron is one of the most common dietary recommendations of registered dieticians, as well as many doctors. The fact that lipofuscin - a highly insoluble complex of iron and PUFA peroxides - increases with age is conveniently ignored in those recommendations. The...
  5. RealNeat

    Ray Peat Interview KMUD - August 19, 2022 Lipofuscin

    I thought this was a good interview about lipofuscin which I'm always looking to find new ways of reversing. Murray says he will upload interviews on their website soon, many recent ones are absent on and KMUD archives only go back about 2 months. If you don't want...
  6. UG Krishnamurti

    Does Ray have lipofuscin on his hands?

    Would you consider these as a lipofuscin? Is it impossible to avoid lipofuscin entirely and just getting it on the hands at that age is not a big deal? These are Rays hands in around 2015 or maybe a bit earlier.
  7. UG Krishnamurti

    More lipofuscin after being LOW PUFA for 2 years

    2 years ago I started being almost fruitarian [medical medium style]. Eating tons of fruits and developed 1 lipofuscin mole on my stomach. I did that diet for 6 months and than switched to Ray Peat. So very low PUFA for 2 years now. Today I've developed about 20 lipofuscin moles on my face and...
  8. haidut

    Alcohol Brain Damage Due To Iron Accumulation; Vitamin B1 To The Rescue

    Chronic alcohol abuse is highly detrimental to health and especially to the brain. Alcohol puts the body in a reductive state and depletes vitamin B1 (thiamine) stores. If the B1 deficiency becomes severe enough it manifests through what is clinically known as Wernicke-Korsakoff syndrome (WKS)...
  9. haidut

    Vitamin B2 (riboflavin) Reduces Lipofuscin, May Extend Lifespan

    There are few reliable treatments of the so-called "age spots" officially known as lipofuscin. Ray has written about the role of iron, PUFA and estrogen in the formation of this skin pigment and has suggested that vitamin E may be one possible treatment. Now we can add vitamin B2 to the list of...
  10. Richiebogie

    The Age Pigment Lipofuscin And The Fountain Of Youth

    In a rare Ray Peat article which does not appear on his webpage we learn that the age pigment lipofuscin builds up in cells and correlates with age. viewtopic.php?t=1219 At the end of the article, Ray Peat recommends avoiding estrogen, excess iron and unsaturated fats. He also recommends...
  11. Rachel

    DMAE For Lipofuscin Removal

    I've heard for many years that DMAE can remove age pigment from the body. ... -age-spots That's a pretty dang high dose of DMAE! Beyond a Century carries it in powder form. Does anyone have personal experience/results with this protocol?
  12. G

    RP Intro II (Lipofuscin, PUFAs, Estrogen)

    RP Intro II (Lipofuscin, PUFAs, Estrogen)
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