lactate

  1. haidut

    The Warburg "effect" Is, In Fact, A Direct Cause Of Cancer

    This is yet another recent study showing that medicine may finally be getting on the right track. Similar to the human study with doxycycline and breast cancer I just posted, confirms again what has been known and fraudulently suppressed for almost a century. Namely, the Warburg "effect" is as...
  2. P

    The Effect Of Training Volume And Intensity On Improvements In Muscular Strength And Size In Resista

    on every parameter high intensity( heavier weight lower reps with longer rest between sets) is superior to high volume exercise , body fat , lean mass, power. also hormones ; cortisol ,T , igf .... everything is better! The effect of training volume and intensity on improvements in muscular...
  3. haidut

    Probiotics Are Dangerous, Should Be Regulated As Drugs

    As many forum users know, Peat has spoken against the use of probiotics and in some of his articles has even linked lactic acid producing bacteria to auto-immune conditions like such as Lupus, RA, and even MS. While recently he has been recommending a bacteriophage product from LEF, he is still...
  4. haidut

    Children Have More Energy And Recover Faster Than Elite Endurance Athletes

    While endurance exercise is hardly the healthiest form of physical activity, triathlon runners are known for their ability to quickly clear lactate out of the blood and metabolite it back into glucose. The ability to handle lactate is good metric of metabolic health and the pyruvate/lactate...
  5. haidut

    Estrogen As The Main Cause Of Cancer And Its Progression

    I think many of the forum users here know about the infamous study that generated a lot of controversy on "scientific" forums like Reddit. It basically showed that the Warburg Effect (overproduction of lactate) is not just an effect but a direct cause of cancer. So, as the top rated comment on...
  6. haidut

    Inosine Powerfully Stimulates Mitochondriogenesis, Oxidative Metabolism & Cell Differentiation

    Yet another absolutely great study on inosine. It shows that not only can inosine replenish ATP (as shown in the previous studies I posted) but it can inhibit excessive glycolysis, lower lactate, and dramatically improve oxidative metabolism - effects which are key driver of cell differentiation...
  7. haidut

    High Lactate May Be The Cause Of Major Psychiatric Disorders

    The study itself has a misleading title because there are quite a few situations that can result in lower brain pH (and thus high acidity). High levels of CO2 can also cause low brain pH levels, but as I posted in a few other studies drugs that raise CO2 levels can actually treat mental disease...
  8. haidut

    The Ability To Metabolize Glucose Is Impaired In CFS/ME Patients

    The enzyme pyruvate dehydrogenase (PDH) is perhaps the single most important factor in proper glucose metabolism and it is often severely downregulated (both in function and levels) in a number of diseases, most notably cancer, diabetes and neurodegenerative conditions. Without proper...
  9. haidut

    Majority Of Cancer Patients Have Vitamin B1 (thiamine) Deficiency

    This is a great study since it directly highlights the metabolic connection between excess lactic acid and cancer. Thiamine deficiency results in lactic acid buildup, and all cancer patients have excess lactic acid due to the Warburg effect. foodconsumer.org - Cancer patients may need thiamine...
  10. P

    Do Not Forget To Give Thiamine To Your Septic Shock Patient!

    Do not forget to give thiamine to your septic shock patient! Thiamine was the first B vitamin to be identified and is also referred to as vitamin B1. It is a water-soluble vitamin that is an indispensable constituent of cellular metabolism (1). A lack of this vitamin can, therefore, be...
  11. P

    Hormonal Responses From Concentric And Eccentric Muscle Contractions

    Hormonal responses from concentric and eccentric muscle contractions. - PubMed - NCBI Abstract Intense resistance exercise can acutely increase testosterone (T), free testosterone (FT), and growth hormone (GH) concentrations, but there are few investigations concerning acute endocrine...
  12. haidut

    Niacinamide Causes Dramatic Increase In Nad And Fall In Lactate

    The good things about this study is that it is human and as such the doses are directly relevant. Given that the patient had MELAS, the niacinamide dose used was on the high end but still quite reasonable and comparable to the human trials of niacinamide in Alzheimer disease and stroke. The...
  13. haidut

    Thiamine Normalizes Pyruvate / Lactate Levels In Rats With Cancer

    Russian study, so I can't get the actual paper and see route of administration, but it was likely oral or intraperitoneal. Human equivalent dosage is 100mg - 150mg daily. http://www.ncbi.nlm.nih.gov/pubmed/664448
  14. haidut

    Thiamine Reduces Both Lactate And Ammonia

    The study was with humans and also included exercise, which makes thiamine even more interesting to athletes. The type of thiamine used was TTFD, which is the scientific name for allithiamine, and the dose was 10mg/kg. That would mean a total daily dose in the range of 600mg-900mg for most...
  15. haidut

    The Diverse Effects Of Lactate Are Finally Being Recognized

    Ray has written a lot on the toxicity of lactate and how it is not just a harmless metabolite. However, modern medicine treats lactate not just as harmless but even as beneficial (for the brain, of all tissues). This latest study is starting to expose the many faces of lactate, even though the...
  16. haidut

    Metformin Is A Mitochondrial Toxin And Raises Lactate

    This study lists some of the possible reasons drugs like Metformin are to be avoided and why Peat has cautioned against it even without explicitly saying what he has against it. Etiology and therapeutic approach to elevated lactate "...One of the first biguanides, phenformin, was withdrawn...
  17. haidut

    Stress-induced glycolysis is mediated by adrenalin

    A nice study that ties together the hypoglycemic state of shock with increased levels of lactate and pyruvate - all caused by adrenalin. Anti-adrenalin agents (beta "receptor" blockers) successfully ameliorated the condition. I wonder if clonidine would do the same given another study I found...
  18. himsahimsa

    Beta-Alanine, Carnosine, Lactate And Histamine

    Beta-alanine is the limiting substrate for the production of Carnosine. Carnosine (not carnitine) is the primary intracellular buffer for lactate. Histidine can take two (at least) metabolic pathways. It can end up as histamine or, if there is a good supply of beta-alanine, the histidine is...
Back
Top Bottom