lactate

  1. A

    Is lactate a driver of skin burn-induced adipose browning?

    https://pubmed.ncbi.nlm.nih.gov/37406182 Abstract High levels of plasma lactate are associated with increased mortality in critically injured patients, including those with severe burns. Although lactate has long been considered a waste product of glycolysis, it was recently revealed that it...
  2. haidut

    Reduced availability/oxidation of glucose sufficient to cause heart failure (HF)

    Yet another "mysterious" idiopathic condition turns out to be nothing but metabolic dysregulation in disguise. Also, unlike many other studies implicating metabolism in disease, this one actually manages to demonstrate that reduction of oxidative glucose metabolism is sufficient to cause severe...
  3. cs3000

    CoQ10 (Ubiquinone) reduces exercise induced lactate increase

    Effects of oral coenzyme Q10 on preventing the accumulation of lactic acid developing during the exercise performances of endurance skiing athletes CoQ10 levels are often reduced in people who do a lot of exercise, people who take statins. 300mg+ may interfere with exercise adaptation. but...
  4. P

    Doxycycline , intestinal health, hypertension

    Changes in Gut Microbiota Induced by Doxycycline Influence in Vascular Function and Development of Hypertension in DOCA-Salt Rats DOX decreased lactate-producing bacterial population and plasma lactate levels, improved gut barrier integrity, normalized endotoxemia, plasma noradrenaline levels...
  5. cs3000

    Sucrose/fructose intake raises lactate in humans, glucose intake doesn't

    Feeding decently high amounts of sugar water vs "glucose" (as 60% dextrose/40% maltodextrin) to people. post-exercise. 1.5g/kg per hour https://journals.physiology.org/doi/full/10.1152/japplphysiol.01023.2015 Plasma glucose is similar for both. insulin is a lot higher from the 60% dextrose...
  6. AlphaCog

    Elite Athletes’ Gut Bacteria Give Rodent Runners a Boost. The chemical these bacteria produce appears to enhance athleticism.

    The study began with an assessment of 15 runners and a comparison of bacterial strains present in their stool before and after they completed the Boston Marathon. The investigators identified a boost in the presence of species the bacterium Veillonella after the marathon, especially Veillonella...
  7. JCastro

    Fructose augments synthesis and release of free fatty acids and lactate

    Metabolic fate of fructose in human adipocytes: a targeted 13C tracer fate association study ”This study demonstrated that fructose stimulates anabolic processes in adipocytes robustly, including glutamate and de novo fatty acid synthesis. Furthermore, fructose also augments the release of free...
  8. A

    Oral lactate slows gastric emptying and suppresses appetite in young males

    https://pubmed.ncbi.nlm.nih.gov/35016146/ Abstract Background: Lactate serves as an alternative energy fuel but is also an important signaling metabolite. We aimed to investigate whether oral lactate administration affects appetite-regulating hormones, slows gastric emptying rate, and dampens...
  9. A

    Lactate in contemporary biology: a phoenix risen

    https://pubmed.ncbi.nlm.nih.gov/33566386 Introduction The story of lactate and its role in physiology and medicine may be a century old, but has changed dramatically in the last three decades (Brooks, 1986, 2002, 2018; Gladden, 2004). No longer conceived of as a dead-end metabolite, a fatigue...
  10. haidut

    Lactate is a key driver of diabetes/obesity, by promoting inflammation

    A great study, demonstrating that in diabetes (just as in cancer) the so-called Warburg Effect (aerobic glycolysis) is as much a cause of those degenerative conditions as it is an effect of. The study below demonstrated that increased intracellular lactate results in robust increase in systemic...
  11. A

    Acute Administration of Exogenous Lactate Increases Carbohydrate Metabolism during Exercise in Mice

    In this study, we investigated the effects of exogenous lactate administration before exercise on energy substrate utilization during exercise. Mice were divided into exercise control (EX) and exercise with lactate intake (EXLA) groups; saline/lactate was administered 30 min before exercise...
  12. A

    Post-Traumatic Stress Disorder as an Endothelial Disease: Insights From COVID-19

    SARS-CoV-2 virus, the etiologic agent of COVID-19, has affected almost every aspect of human life, precipitating stress-related pathology in vulnerable individuals. As the prevalence rate of posttraumatic stress disorder in pandemic survivors exceeds that of the general and special populations...
  13. Mauritio

    Allithiamine increases physical performance 7-fold, increases glycogen storage and glucose utilization

    Interesting study. I think it's widely known that vitamin B1 increases glucose metabolism , and it does so partly because it increases glycogen storage . So theres no/ less need for cortisol to kick in during a workout . And as you can see In the figure below glucose utilization only increases...
  14. Hans

    Cocoa powder for gut health

    I've posted a few studies before that cocoa powder can help to reduce gut inflammation and positively modulate the gut bacteria. Here is another one: https://pubmed.ncbi.nlm.nih.gov/32331673/ "We found that cocoa supplementation up-regulated the levels of the tight junction protein Zonula...
  15. haidut

    Reduced pyruvate and/or increased lactate drive heart failure

    I just did a post on the role of reduced glucose metabolism, lower pyruvate/NAM/NAD and elevated lactate in the pathogenesis of glaucoma. Just minutes later, another study popped up in my newsfeed. Namely, a study that demonstrates the exact same metabolic disturbances as the main drivers of...
  16. haidut

    Niacinamide may treat ALS by improving energetic state

    Another study sent to me by the Austrian collaborator. Once again, the energetic origin of "incurable" diseases like amyotrophic lateral sclerosis (ALS) is on full display. The study elucidates that ALL types of ALS are characterized by metabolic/energetic abnormalities and the metabolic...
  17. Hans

    An optimal metabolism: a look at the furnace within

    What should a true metabolism look like? What should we even look at? I dived a bit deep on this one and hopefully it provides answers for some. I'm discussing redox couples, such as NAD/NADH, GSH/GSSG and cysteine/cystine and how they affect energy production, ROS, hormone and neurotransmitter...
  18. haidut

    Lactate Is An Oncometabolite (promotes Cancer), No Genes/mutations Needed

    It has now been more than 5 years since a seminal post/discussion on Reddit raised the question publicly of whether the dominant medical theory on cancer may actually be nothing but an elaborate fraud. Namely, a study that spurred the Reddit discussion demonstrated that that the so-called...
  19. haidut

    Acidosis (Warburg Effect) Drives Cancer Through Increased Fat Oxidation (Randle Cycle)

    The evidence continues to pile on that naming the (in)famous observation made by Otto Warburg in regards to cancer an "effect" is one of the most profound falsehoods the medical profession has ever concocted. Almost a century after the Warburg "Effect" term was coined, the evidence rapidly...
  20. haidut

    (Brain) Cancer Is A Metabolic Disease, Can Be Treated By Glutamine Restriction

    It seems that mainstream medicine is finally wisening up to the massacre they have been orchestrating for the last 100 years. Without much fanfare or apologies, medicine is now quietly changing its story on cancer, hoping the public won't notice as long as a cure is finally found. The study...
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