lactate

  1. Mauritio

    Allithiamine increases physical performance 7-fold, increases glycogen storage and glucose utilization

    Interesting study. I think it's widely known that vitamin B1 increases glucose metabolism , and it does so partly because it increases glycogen storage . So theres no/ less need for cortisol to kick in during a workout . And as you can see In the figure below glucose utilization only increases...
  2. Hans

    Cocoa powder for gut health

    I've posted a few studies before that cocoa powder can help to reduce gut inflammation and positively modulate the gut bacteria. Here is another one: https://pubmed.ncbi.nlm.nih.gov/32331673/ "We found that cocoa supplementation up-regulated the levels of the tight junction protein Zonula...
  3. haidut

    Reduced pyruvate and/or increased lactate drive heart failure

    I just did a post on the role of reduced glucose metabolism, lower pyruvate/NAM/NAD and elevated lactate in the pathogenesis of glaucoma. Just minutes later, another study popped up in my newsfeed. Namely, a study that demonstrates the exact same metabolic disturbances as the main drivers of...
  4. haidut

    Niacinamide may treat ALS by improving energetic state

    Another study sent to me by the Austrian collaborator. Once again, the energetic origin of "incurable" diseases like amyotrophic lateral sclerosis (ALS) is on full display. The study elucidates that ALL types of ALS are characterized by metabolic/energetic abnormalities and the metabolic...
  5. Hans

    An optimal metabolism: a look at the furnace within

    What should a true metabolism look like? What should we even look at? I dived a bit deep on this one and hopefully it provides answers for some. I'm discussing redox couples, such as NAD/NADH, GSH/GSSG and cysteine/cystine and how they affect energy production, ROS, hormone and neurotransmitter...
  6. haidut

    Lactate Is An Oncometabolite (promotes Cancer), No Genes/mutations Needed

    It has now been more than 5 years since a seminal post/discussion on Reddit raised the question publicly of whether the dominant medical theory on cancer may actually be nothing but an elaborate fraud. Namely, a study that spurred the Reddit discussion demonstrated that that the so-called...
  7. haidut

    Acidosis (Warburg Effect) Drives Cancer Through Increased Fat Oxidation (Randle Cycle)

    The evidence continues to pile on that naming the (in)famous observation made by Otto Warburg in regards to cancer an "effect" is one of the most profound falsehoods the medical profession has ever concocted. Almost a century after the Warburg "Effect" term was coined, the evidence rapidly...
  8. haidut

    (Brain) Cancer Is A Metabolic Disease, Can Be Treated By Glutamine Restriction

    It seems that mainstream medicine is finally wisening up to the massacre they have been orchestrating for the last 100 years. Without much fanfare or apologies, medicine is now quietly changing its story on cancer, hoping the public won't notice as long as a cure is finally found. The study...
  9. haidut

    The Warburg "effect" Is, In Fact, A Direct Cause Of Cancer

    This is yet another recent study showing that medicine may finally be getting on the right track. Similar to the human study with doxycycline and breast cancer I just posted, confirms again what has been known and fraudulently suppressed for almost a century. Namely, the Warburg "effect" is as...
  10. P

    The Effect Of Training Volume And Intensity On Improvements In Muscular Strength And Size In Resista

    on every parameter high intensity( heavier weight lower reps with longer rest between sets) is superior to high volume exercise , body fat , lean mass, power. also hormones ; cortisol ,T , igf .... everything is better! The effect of training volume and intensity on improvements in muscular...
  11. haidut

    Probiotics Are Dangerous, Should Be Regulated As Drugs

    As many forum users know, Peat has spoken against the use of probiotics and in some of his articles has even linked lactic acid producing bacteria to auto-immune conditions like such as Lupus, RA, and even MS. While recently he has been recommending a bacteriophage product from LEF, he is still...
  12. haidut

    Children Have More Energy And Recover Faster Than Elite Endurance Athletes

    While endurance exercise is hardly the healthiest form of physical activity, triathlon runners are known for their ability to quickly clear lactate out of the blood and metabolite it back into glucose. The ability to handle lactate is good metric of metabolic health and the pyruvate/lactate...
  13. haidut

    Estrogen As The Main Cause Of Cancer And Its Progression

    I think many of the forum users here know about the infamous study that generated a lot of controversy on "scientific" forums like Reddit. It basically showed that the Warburg Effect (overproduction of lactate) is not just an effect but a direct cause of cancer. So, as the top rated comment on...
  14. haidut

    Inosine Powerfully Stimulates Mitochondriogenesis, Oxidative Metabolism & Cell Differentiation

    Yet another absolutely great study on inosine. It shows that not only can inosine replenish ATP (as shown in the previous studies I posted) but it can inhibit excessive glycolysis, lower lactate, and dramatically improve oxidative metabolism - effects which are key driver of cell differentiation...
  15. haidut

    High Lactate May Be The Cause Of Major Psychiatric Disorders

    The study itself has a misleading title because there are quite a few situations that can result in lower brain pH (and thus high acidity). High levels of CO2 can also cause low brain pH levels, but as I posted in a few other studies drugs that raise CO2 levels can actually treat mental disease...
  16. haidut

    The Ability To Metabolize Glucose Is Impaired In CFS/ME Patients

    The enzyme pyruvate dehydrogenase (PDH) is perhaps the single most important factor in proper glucose metabolism and it is often severely downregulated (both in function and levels) in a number of diseases, most notably cancer, diabetes and neurodegenerative conditions. Without proper...
  17. haidut

    Majority Of Cancer Patients Have Vitamin B1 (thiamine) Deficiency

    This is a great study since it directly highlights the metabolic connection between excess lactic acid and cancer. Thiamine deficiency results in lactic acid buildup, and all cancer patients have excess lactic acid due to the Warburg effect. foodconsumer.org - Cancer patients may need thiamine...
  18. P

    Do Not Forget To Give Thiamine To Your Septic Shock Patient!

    Do not forget to give thiamine to your septic shock patient! Thiamine was the first B vitamin to be identified and is also referred to as vitamin B1. It is a water-soluble vitamin that is an indispensable constituent of cellular metabolism (1). A lack of this vitamin can, therefore, be...
  19. P

    Hormonal Responses From Concentric And Eccentric Muscle Contractions

    Hormonal responses from concentric and eccentric muscle contractions. - PubMed - NCBI Abstract Intense resistance exercise can acutely increase testosterone (T), free testosterone (FT), and growth hormone (GH) concentrations, but there are few investigations concerning acute endocrine...
  20. haidut

    Niacinamide Causes Dramatic Increase In Nad And Fall In Lactate

    The good things about this study is that it is human and as such the doses are directly relevant. Given that the patient had MELAS, the niacinamide dose used was on the high end but still quite reasonable and comparable to the human trials of niacinamide in Alzheimer disease and stroke. The...
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