lactate

Effects of oral coenzyme Q10 on preventing the accumulation of lactic acid developing during the exercise performances of endurance skiing athletes CoQ10 levels are often reduced in people who do a lot of exercise, people who take statins. 300mg+ may interfere with exercise adaptation. but...

Changes in Gut Microbiota Induced by Doxycycline Influence in Vascular Function and Development of Hypertension in DOCA-Salt Rats DOX decreased lactate-producing bacterial population and plasma lactate levels, improved gut barrier integrity, normalized endotoxemia, plasma noradrenaline levels...

Feeding decently high amounts of sugar water vs "glucose" (as 60% dextrose/40% maltodextrin) to people. post-exercise. 1.5g/kg per hour https://journals.physiology.org/doi/full/10.1152/japplphysiol.01023.2015 Plasma glucose is similar for both. insulin is a lot higher from the 60% dextrose...

The study began with an assessment of 15 runners and a comparison of bacterial strains present in their stool before and after they completed the Boston Marathon. The investigators identified a boost in the presence of species the bacterium Veillonella after the marathon, especially Veillonella...

Metabolic fate of fructose in human adipocytes: a targeted 13C tracer fate association study ”This study demonstrated that fructose stimulates anabolic processes in adipocytes robustly, including glutamate and de novo fatty acid synthesis. Furthermore, fructose also augments the release of free...

https://pubmed.ncbi.nlm.nih.gov/35016146/ Abstract Background: Lactate serves as an alternative energy fuel but is also an important signaling metabolite. We aimed to investigate whether oral lactate administration affects appetite-regulating hormones, slows gastric emptying rate, and dampens...

https://pubmed.ncbi.nlm.nih.gov/33566386 Introduction The story of lactate and its role in physiology and medicine may be a century old, but has changed dramatically in the last three decades (Brooks, 1986, 2002, 2018; Gladden, 2004). No longer conceived of as a dead-end metabolite, a fatigue...

A great study, demonstrating that in diabetes (just as in cancer) the so-called Warburg Effect (aerobic glycolysis) is as much a cause of those degenerative conditions as it is an effect of. The study below demonstrated that increased intracellular lactate results in robust increase in systemic...

In this study, we investigated the effects of exogenous lactate administration before exercise on energy substrate utilization during exercise. Mice were divided into exercise control (EX) and exercise with lactate intake (EXLA) groups; saline/lactate was administered 30 min before exercise...

SARS-CoV-2 virus, the etiologic agent of COVID-19, has affected almost every aspect of human life, precipitating stress-related pathology in vulnerable individuals. As the prevalence rate of posttraumatic stress disorder in pandemic survivors exceeds that of the general and special populations...

Interesting study. I think it's widely known that vitamin B1 increases glucose metabolism , and it does so partly because it increases glycogen storage . So theres no/ less need for cortisol to kick in during a workout . And as you can see In the figure below glucose utilization only increases...

I've posted a few studies before that cocoa powder can help to reduce gut inflammation and positively modulate the gut bacteria. Here is another one: https://pubmed.ncbi.nlm.nih.gov/32331673/ "We found that cocoa supplementation up-regulated the levels of the tight junction protein Zonula...

I just did a post on the role of reduced glucose metabolism, lower pyruvate/NAM/NAD and elevated lactate in the pathogenesis of glaucoma. Just minutes later, another study popped up in my newsfeed. Namely, a study that demonstrates the exact same metabolic disturbances as the main drivers of...

Another study sent to me by the Austrian collaborator. Once again, the energetic origin of "incurable" diseases like amyotrophic lateral sclerosis (ALS) is on full display. The study elucidates that ALL types of ALS are characterized by metabolic/energetic abnormalities and the metabolic...

What should a true metabolism look like? What should we even look at? I dived a bit deep on this one and hopefully it provides answers for some. I'm discussing redox couples, such as NAD/NADH, GSH/GSSG and cysteine/cystine and how they affect energy production, ROS, hormone and neurotransmitter...

It has now been more than 5 years since a seminal post/discussion on Reddit raised the question publicly of whether the dominant medical theory on cancer may actually be nothing but an elaborate fraud. Namely, a study that spurred the Reddit discussion demonstrated that that the so-called...

The evidence continues to pile on that naming the (in)famous observation made by Otto Warburg in regards to cancer an "effect" is one of the most profound falsehoods the medical profession has ever concocted. Almost a century after the Warburg "Effect" term was coined, the evidence rapidly...

It seems that mainstream medicine is finally wisening up to the massacre they have been orchestrating for the last 100 years. Without much fanfare or apologies, medicine is now quietly changing its story on cancer, hoping the public won't notice as long as a cure is finally found. The study...

This is yet another recent study showing that medicine may finally be getting on the right track. Similar to the human study with doxycycline and breast cancer I just posted, confirms again what has been known and fraudulently suppressed for almost a century. Namely, the Warburg "effect" is as...

on every parameter high intensity( heavier weight lower reps with longer rest between sets) is superior to high volume exercise , body fat , lean mass, power. also hormones ; cortisol ,T , igf .... everything is better! The effect of training volume and intensity on improvements in muscular...