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  1. haidut

    Ethanol Intoxication / Sedation Caused By Adrenaline

    I came across this during research into increasing dopaminergic activity without also increasing adrenergic tone. Apparently, the feeling of getting drunk as well as the sedation produced by alcohol is due to the increased synthesis of adrenaline (epinephrine). Blocking that synthesis by...
  2. haidut

    Pregnenolone May Protect From Marijuana Intoxication

    A lot of people smoke weed these days, and it happens to be highly anti-androgenic and serotonergic. But if it is helpful for some people then it would be nice if there was a way to mitigate some of the undesirable effects. It looks like pregnenolone may be able to help...