insulin sensitivity

  1. P

    Iron Decreases Adiponectin - Phlebotomy(blood Donation),Manganese,zinc,vitamin D Increasing It

    Adipocyte iron regulates adiponectin and insulin sensitivity. - PubMed - NCBI Iron overload is associated with increased diabetes risk. We therefore investigated the effect of iron on adiponectin, an insulin-sensitizing adipokine that is decreased in diabetic patients. In humans, normal-range...
    • paymanz
    • Thread
    • adiponectin blood donation diabetes fatty liver inflammation insulin sensitivity iron iron-overload light therapy lllt manganese nafld tnf vitamin d zinc
    • Replies: 0
    • Forum: Articles & Scientific Studies
  2. haidut

    DHT Lowers Risk Of Diabetes In Older Males

    Most endocrinologists view DHT as an almost exclusively bad hormone. Aside from the its much publicized (and likely incorrect) role in prostate cancer and MPB, endocrinologists consider DHT as a causative agent in insulin resistance and even diabetes type II. Most of that misguided opinion...
    • haidut
    • Thread
    • dht diabetes insulin resistance insulin sensitivity males men older shbg study type 2
    • Replies: 9
    • Forum: Scientific Studies
  3. haidut

    Androsterone - A Potential Treatment For Insulin Resistance And Diabetes

    In another recent thread, I posted about androsterone's potent thyromimetic effects. Given the ability of thyroid hormone to improve insulin sensitivity and even reverse diabetes type II, it would not be surprising that androsterone would also exhibit such effects. And indeed, androsterone...
    • haidut
    • Thread
    • androsterone diabetes insulin insulin resistance insulin sensitivity type 2
    • Replies: 2
    • Forum: Scientific Studies
  4. P

    Is Insulin Resistance A Result Of Impaired Beta Oxidation Or Excessive Beta Oxidation?

    Peat's obviously a big believer that healthy glucose metabolism should be favored over beta oxidation, and that many factors, including PUFA, excessive lypolysis, serotonin, estrogen, cortisol, lactate, and inflammation all steer the body away from oxidative metabolism, leading to even more...
  5. P

    Biotin Decreases Serum Free Fatty Acids

    Effects of Biotin Supplementation in the Diet on Adipose Tissue cGMP Concentrations, AMPK Activation, Lipolysis, and Serum-Free Fatty Acid Levels. - PubMed - NCBI Several studies have shown that pharmacological concentrations of biotin decrease hyperlipidemia. The molecular mechanisms by which...
  6. P

    Effects Of Excess Dietary Iron And Fat On Glucose And Lipid Metabolism

    Effects of excess dietary iron and fat on glucose and lipid metabolism. - PubMed - NCBI Abstract PURPOSE: Diets rich in fat and energy are associated with metabolic syndrome (MS). Increased body iron stores have been recognized as a feature of MS. High-fat diets (HFs), excess iron loading and...
    • paymanz
    • Thread
    • diabetes fatty liver high-fat insulin resistance insulin sensitivity iron iron-overload metabolic syndrome study
    • Replies: 5
    • Forum: Articles & Scientific Studies
  7. P

    Acute Effects Of Concentric And Eccentric Exercise On Glucose Metabolism And Interleukin-6 Concentra

    Acute effects of concentric and eccentric exercise on glucose metabolism and interleukin-6 concentration in healthy males Acute muscle-damaging eccentric exercise (EE) negatively affects glucose metabolism. On the other hand, long-term eccentric endurance exercise seems to result in equal or...
  8. haidut

    Aspirin (salicylic Acid) Inhibits Cortisol Synthesis

    I posted several studies on aspirin and sodium salicylate being effective in reversing insulin resistance and type II diabetes in humans. However, to my knowledge the mechanism of action of aspirin and other prodrugs for salicylic acid has never been publicly elucidated even though Ray has...
    • haidut
    • Thread
    • 11β-hsd1 adipose tissue aspirin cortisol inhibition insulin sensitivity salsalate sodium salicylate study
    • Replies: 10
    • Forum: Scientific Studies
  9. Dan W

    Caffeine Improving Sugar Handling And Fat Accumulation In Rats

    I finally managed to post a study before Haidut's high-powered laser-guided tracking system could beat me to it. Caffeine Restores Insulin Sensitivity and Glucose tolerance in High-sucrose Diet Rats: Effects on Adipose Tissue The concentrations necessary might not be as high as they sound...
    • Dan W
    • Thread
    • caffeine diabetes insulin resistance insulin sensitivity obesity study
    • Replies: 1
    • Forum: Scientific Studies
  10. milk_lover

    Selenium Supplementation Increases Insulin Sensitivity -- New (2016) Study Reveals

    I remember seeing from the forum that Ray Peat thinks the amount of selenium in commercial farmed seafood is low and it would be wise to supplement it in the diet. In one of his articles, he mentioned selenium along with other nutrients (K2, thiamine, niacinamide etc.,) to be good for...
  11. haidut

    Even Intermittent Fasting Reduces Insulin Sensitivity (in The Obese)

    The study was in diabetic patients (Type II) so probably does not apply to all healthy people. However, it is still pretty telling that skipping only breakfast has such a potent and long lasting (post- lunch and dinner) effect on insulin sensitivity. http://care.diabetesjournals.org/conten ...
    • haidut
    • Thread
    • diabetes fasting insulin sensitivity intermittend fasting study type 2
    • Replies: 92
    • Forum: Scientific Studies
  12. haidut

    TSH associated with insulin resistance even in euthyroid people

    The study looked at obese but non-diabetic people who had average TSH levels of 2.7 - a level Peat would consider indicative of hypothyroidism, but considered normal by medical standards. In men, the TSH levels were predictive of impaired insulin sensitivity so I think this is yet another...
  13. haidut

    Low dose DHEA restores insulin sensitivity by increasing DHT

    This is one study that used doses of DHEA close to what Peat would recommend, and not the megadosing schedules likely to result in conversion into estrogen. The human equivalent dose was <15mg per day and resulted in 71% increases in DHT. It is that increase in DHT and DHEA levels that is behind...
  14. N

    Inhibition of Lipolysis Improves Glucose Metabolism, Insulin Sensitivity w/o Altering Fat Mass

    Not really news for Peat followers but this study might give a hint on what happens when we suppress lipolysis e.g. via Niacinamide: http://www.plosbiology.org/article/info ... io.1001485 When energy is needed, white adipose tissue (WAT) provides fatty acids (FAs) for use in peripheral tissues...
  15. mmartian

    Hack This: Moderate Fructose Impairs Insulin Sensitivity

    Stephan Guyenet just tweeted this study: Moderate Amounts of Fructose Consumption Impair Insulin Sensitivity in Healthy Young Men A randomized controlled trial Abstract OBJECTIVE Adverse effects of hypercaloric, high-fructose diets on insulin sensitivity and lipids in human subjects have been...
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