inhibition

  1. cs3000

    11b-HSD1 inhibitors don't lower cortisol levels? increased ACTH response

    a lot of people try to lower cortisol this way. But these studies with a 11b-hsd1 inhibitor given to humans shows plasma cortisol levels stay the same regardless and ACTH levels rise. (ACTH rises in response to the lower conversion of cortisone -> cortisol from the enzyme inhibition, so with...
    • cs3000
    • Thread
    • 11b-hsd1 11β-hydroxysteroid dehydrogenase 11β-hydroxysteroid dehydrogenase type 1 acth cortisol enzyme inhibition lowering
    • Replies: 1
    • Forum: Scientific Studies
  2. haidut

    Fatty Acid Oxidation (FAO) Inhibition Abrogates Triple-negative Breast Cancer

    The evidence for the role of excessive FAO in cancer keeps piling on. As many of my readers know, triple-negative breast cancer is one of the most difficult to treat and its proportion of total breast cancer cases has been steadily rising over the last 20 years. When a patient is diagnosed with...
    • haidut
    • Thread
    • abrogate breast cancer cure fao fatty acid oxidation inhibition tnbc triple-negative
    • Replies: 2
    • Forum: Scientific Studies
  3. haidut

    Inhibiting Lipolysis May Treat / Cure Cancer

    I posted a number of threads over the last 6 months that show cancer's appetite for fat and how inhibiting fatty acid oxidation or transport into the cell can have dramatic therapeutic results even for highly lethal malignancies like pancreatic cancer. Triple-Negative Breast Cancers Depend On...
    • haidut
    • Thread
    • cancer cure hibernation inhibition lipolysis niacinamide stem cells treat
    • Replies: 50
    • Forum: Scientific Studies
  4. haidut

    PUFA And MUFA Are Strong Inhibitors Of 5-AR, Saturated Fatty Acids Are Not

    I have posted quite a few studies showing the effects of various fatty acids on estrogen, androgen and glucocorticoid synthesis. This study shows that both PUFA and MUFA are strong inhbitors of 5-AR, with PUFA being the more potent inhibitors and inhibition potency being strongly dependent on...
    • haidut
    • Thread
    • 5-alpha reductase androgens dht inhibition inhibitor mufa prostaglandins pufa
    • Replies: 54
    • Forum: Scientific Studies
  5. haidut

    Aspirin Is A Janus Kinase (JK) Inhibitor

    The so-called JK inhibitor drugs are all the rage right now for a number of chronic inflammatory conditions including IBD, RA, Lupus, MS, cancer and Alzheimer. This study found that aspirin (salicylic acid) is a potent JK inhibitor and as such relevant for all the conditions mentioned above. Not...
    • haidut
    • Thread
    • ampk aspirin cancer inflammation inhibition inhibitor jak janus jk kinase
    • Replies: 1
    • Forum: Scientific Studies
  6. haidut

    Nitrates / Nitrites Inhibit Androgen Synthesis By Raising NO

    Ray had a separate newsletter and a radio show on the dangers of NO precursors like dietary nitrates / nitrites and supplements like arginine. It is a bit ironic that quite a few bodybuilders out there pay a lot of money for the so-called NO boosters and in reality get the exact opposite effect...
    • haidut
    • Thread
    • androgen synthesis inhibition nitrates nitric oxide nitrites steroidogenesis study
    • Replies: 17
    • Forum: Scientific Studies
  7. haidut

    Acetylcholine Has Negative Effects On Gonadal Steroidogenesis

    Choline and acetylcholine are another topic that often pops up online. Cholinergic drugs are still the main "treatment" for Alzheimer, even though all of them are abject failure clinically. Ray has written about the excititoxic properties of acetylcholine, and how estrogen manifests its effects...
    • haidut
    • Thread
    • androgen synthesis choline inhibition leydig nicotine receptors steroid study testicular testosterone
    • Replies: 40
    • Forum: Scientific Studies
  8. haidut

    Pineal Gland Chemicals Inhibit Androgen Synthesis

    There is great interest in the blogosophere in writing about and supplementing with the pineal hormone melatonin. Ray has written about the dangers of melatonin, but there is enough contradictory research to confuse people. This study shows that another pineal hormone, which ALWAYS rises...
    • haidut
    • Thread
    • androgens hormone inhibition melatonin methoxytryptamine mtn pineal steroid study
    • Replies: 2
    • Forum: Scientific Studies
  9. haidut

    Low-dose Glycine May Treat Alcoholic Delirium / Hallucinosis In Humans

    The symptoms of alcohol withdrawal and its associated delirium are due mostly to serotonin overload and functional GABA deficiency. As such, anti-serotonin drugs can be very beneficial but they often have side effects and cannot be freely obtained. This human study showed that a single...
    • haidut
    • Thread
    • alcohol alcoholism delirium glycine hallucinosis inhibition neurotransmitter study withdrawal
    • Replies: 7
    • Forum: Scientific Studies
  10. haidut

    Inhibiting Serotonin During Protein Feeding Doubles Maximum Lifespan

    This study is actually on the effects of a high protein diet on brain neurotransmitters and lifespan. It was done in fruit flies but the serotonin in those fruit flies are essentially the same in humans. So, the results should hold. One of the big takeaways from the study is the explanation of...
    • haidut
    • Thread
    • 5-ht2 caloric restriction doubles food inhibition lifespan perceived protein reward serotonin starvation tph
    • Replies: 14
    • Forum: Scientific Studies
  11. haidut

    PPI Drugs (anti GERD) Powerfully Inhibit Steroidogenesis

    I have always been suspicious of PPI drugs. There are many reasons for it, including the falsified clinical trial data to conceal increased risk of gastric cancer, the idiotic premise that gastric acid increases with age, the kidney failure side effects, and the calcium/magnesium depletion being...
    • haidut
    • Thread
    • cholesterol gerd inhibition inhibitor ppi pregnenolone side cleavage side cleavage enzyme steroidogenesis steroids
    • Replies: 3
    • Forum: Scientific Studies
  12. haidut

    DHT Lowers Serotonin Synthesis, May Treat (testicular) Cancer

    This is a great study for a number of reasons. 1. First, it suggests that DHT is not the evil substances for male reproductive organs. This includes prostate cancer, for which DHT to this day is cite as the main culprit. 2. Second, the study establishes the key role serotonin plays in the...
  13. haidut

    Aspirin (salicylic Acid) Inhibits Cortisol Synthesis

    I posted several studies on aspirin and sodium salicylate being effective in reversing insulin resistance and type II diabetes in humans. However, to my knowledge the mechanism of action of aspirin and other prodrugs for salicylic acid has never been publicly elucidated even though Ray has...
    • haidut
    • Thread
    • 11β-hsd1 adipose tissue aspirin cortisol inhibition insulin sensitivity salsalate sodium salicylate study
    • Replies: 10
    • Forum: Scientific Studies
  14. haidut

    Coffee Inhibits Cortisol Synthesis

    I was really pleased to see that study for two reasons. First, it gives more credibility to Peat's statement that coffee/caffeine do NOT boost cortisol, contrary to what many people claim and would like to believe. This matches well the few animal studies I have posted showing caffeine and...
    • haidut
    • Thread
    • 11β-hsd1 article coffee cortisol espresso inhibition
    • Replies: 60
    • Forum: Scientific Studies
  15. haidut

    Niacinamide Is Anti-estrogenic

    Yet another strong point for niacinamide. I am beginning to wonder if there is any condition or biomarker of disease that niacinamide cannot affect. Peat has written many times about the sirtuin genes and their promoter resveratrol. While there is already quite a bit of evidence that SIRT1...
    • haidut
    • Thread
    • antagonist estrogen fulvestrant hdac inhibition niacinamide sirt1 sirtuins study suppression
    • Replies: 36
    • Forum: Scientific Studies
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