inflammation

  1. haidut

    Progesterone May Bind And Deactivate Endotoxin (LPS) Directly

    I made a few posts recently discussing the blocking effects of pregnenolone on TLR4 and TLR family receptors in general, and the reduction of systemic inflammation stemming from this blockade/regulation...
  2. haidut

    PUFA (metabolites) Drive Heart Failure And Possibly Diabetes

    Over the years I have posted a number of studies on the roles of PUFA metabolites such as prostaglandins and leukotrienes in many chronic conditions including cancer, Alzheimer, Parkinson, ALS, MS, CVD, etc. For those that are new to this issue, COX enzymes are responsible for prostaglandin...
  3. P

    Prebiotic And Anti Endotoxin Effects Of Dietary Calcium

    Calcium supplementation modulates gut microbiota in a prebiotic manner in dietary obese mice. - PubMed - NCBI Could the beneficial effects of dietary calcium on obesity and diabetes control be mediated by changes in intestinal microbiota and integrity? - PubMed - NCBI
  4. haidut

    Vitamin D Deficiency Can Cause Heart Failure

    As many readers know, there is an epidemic of vitamin D deficiency. It is of worldwide proportions, but is visible mainly in "developed" countries in the Western world. The official stance of mainstream medicine is that while vitamin D deficiency is undesirable, it does not really have much...
  5. haidut

    Blocking Endotoxin (LPS) May Reverse/cure Diabetes Type I

    Yet another study demonstrating the key role of endotoxin in the pathology of perhaps the most widespread chronic disease - diabetes. The study below discovered that the proliferation of the insulin-producing beta-cells in the pancreas is controlled almost entirely by the TLR4/TLR2 receptor...
  6. haidut

    Endotoxin (LPS) May Cause Depression / Anhedonia

    As many readers know, anhedonia is one of the most pernicious aspects of clinical depression. It is present in other mental health conditions but is most pronounced and severe in clinical unipolar depression. It is also especially resistant to treatment and many doctors simply accept it as...
  7. haidut

    Osteoporosis Is Caused By Mitochondrial Dysfunction Driven By Nitric Oxide (NO)

    Let’s repeat the mantra one more time – structure and function cannot be separated, they are mutually dependent at every level of reality/life. As such, it is little surprise (to us) that a structural disorder like osteoporosis may be caused by a deficiency in energy production. Yet, despite...
  8. haidut

    Endotoxin (LPS) May Be A Major Cause Of Preterm Births

    As many readers have probably heard, rates of preterm births due to a variety of maternal conditions including (pre)eclampsia has been steadily increasing since the 1980s. The official version is that the cause is unknown despite older studies proving definitively that progesterone deficiency...
  9. haidut

    All Gut Bacteria Dangerous, Its Endotoxin Drives Liver Cancer; Antibiotics Cure

    As Peat has written many times, there is truly no such thing as “beneficial” gut bacteria as long as they are capable of producing endotoxin (LPS). And since most bacterial species known to colonize the gut can produce LPS when exposed to undigested food or mechanical stimulation (stretching or...
  10. haidut

    Damaged Mitochondria And Endotoxin (LPS) Drive Chronic Inflammation

    Chronic, low-grade inflammation has now been recognized as the main cause behind a number of chronic degenerative conditions including CVD, diabetes, cancer, Alzheimer, Parkinson, etc. Mainstream medicine claims that the cause of this chronic low-grade inflammatory reaction is unknown, despite...
  11. ecstatichamster

    Inhaled Sugar May Lower Inflammation

    Is sugar the key to treating lung problems? The lung environment controls alveolar macrophage metabolism and responsiveness in type 2 inflammation So type 2 immunity is the characterization of “allergies” Type 2 immunity in tissue repair and fibrosis Type 2 immunity is characterized by the...
  12. haidut

    Low-carb Diet Damages Blood Vessels In Humans

    I posted a study recently showing that low-carb diets increase risk for a potentially fatal heart rhythm disorder known as AFib. https://raypeatforum.com/community/threads/low-carb-diets-may-cause-lethal-heart-rhythm-disorder-afib.28169/ Now this new, also human, study below shows that even a...
  13. haidut

    A Lab Test For Endotoxin Exposure, And Its Role In HIV/AIDS

    While I was researching some other topics related to the article on statins and TLR4 that I posted last week, I stumbled upon a biomarker called "soluble CD14" or sCD14 for short. CD14 - Wikipedia As it turns out, sCD14 is a biomarker for systemic endotoxin load. The importance of soluble CD14...
  14. haidut

    PUFA/Statins Promote UV Damage & Skin Cancer (melanoma), Cholesterol Is Protective

    Several people asked Peat over email about the dangers of sun exposure. He responded by saying that the main danger is the lipid (PUFA) perodixation caused by the UV lights and that taking some aspirin, vitamin E, or niacinamide greatly reduces the damage. The study below confirms that PUFA may...
  15. haidut

    Pregnenolone Is A Potent (functional) Endotoxin (TLR4) Antagonist

    It seems that pregnenolone is finally starting to look exciting to the medical industry. In addition for its intensive studies for a variety of mental issues, now studies are coming out demonstrating its endotoxin (LPS) antagonism effects. As most forum users know, endotoxin exerts its effects...
  16. haidut

    Low-dose Aspirin Blocks Multiple Sclerosis (MS) And Reverses Its Damage

    A few years ago I posted a study showing that 1.2g aspirin daily greatly ameliorated fatigue in MS patients and was considered safe enough even at that high dose to be recommended for daily use. Sunlight And Aspirin Can Treat Multiple Sclerosis (MS) However, those studies did not look at...
  17. P

    “NO” To Autophagy: Fat Does The Trick For Diabetes

    “NO” to Autophagy: Fat Does the Trick for Diabetes During the progression from obesity to diabetes, a critical attribute is inability to maintain metabolic homeostasis under excessive energy and nutrient exposure, which triggers insulin resistance. Intensive research efforts have linked chronic...
  18. haidut

    PUFA As The Main Cause Of Cardiovascular Disease (CVD) And Organ Failure

    Some more evidence on the role of PUFA as a big factor in CVD. While the evidence is not widely discussed on mainstream media, and a few saboteur attempt against coconut oil have recently been published, nonetheless a few "runaways" do make it to front page news and we have posted them on the...
  19. haidut

    Periodontal Disease Can Cause Alzheimer's Disease (AD)

    Peat has written many times on the link between periodontal disease, and endotoxin. He mentioned how a few dentists he knows stopped doing dental cleaning after they found that that giving their patients laxatives or antibiotics cured their gum disease. In addition, a few studies came out...
  20. haidut

    Stress As The Underlying Cause Behind ALL Chronic Diseases

    One of the more controversial of Ray's statements is that chronic stress is the underlying cause of many/most chronic conditions, especially autoimmune ones. In several of his articles he describes the role tissue damage under the influence of cortisol and estrogen play in creating an immune...
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