inflammation

  1. L

    What Company Sells The Best Cascara Sagrada On The Market?

    Where do you buy yours?
    • Logan-
    • Thread
    • bacteria biofilm cascara sagrada gut bacteria gut flora gut motility inflammation intestinal barrier intestinal permeability maltodextrin
    • Replies: 18
    • Forum: Cascara Sagrada
  2. B

    Carrageenan Induced Ankle Edema

    Another Ray Peat life lesson for me. Yesterday, both my husband and I awakened with edema of both our ankles. When thinking about any new supplements or new foods, we came up with only the NY cheesecake we ate a couple of nights ago. So, we figured out that the cream cheese used to make the...
    • Birdie
    • Thread
    • carrageenan cream cheese edema experience inflammation ray peat
    • Replies: 20
    • Forum: Testimonials
  3. haidut

    Pregnenolone (P5) - A New Osteoporosis Drug

    About a month ago, I made a post in regards to aspirin becoming a new treatment for osteoporosis. Several months ago, I made another post about an in-vitro study demonstrating powerful anabolic effects of pregnenolone (P5) on bones. Apparently, the protective effects of P5 on bone health are...
    • haidut
    • Thread
    • endotoxin inflammation lps menopause osteoporosis p5 pregnenolone prevent treat
    • Replies: 3
    • Forum: Scientific Studies
  4. haidut

    Niacinamide May Treat Fibrotic Eye Disease And Prevent Vision Loss

    A great new study that demonstrated nicotinamide (NAM) may also have anti-fibrotic effects in addition to its positive effects on maintaining favorable NAD/NADH ratio and redox balance. The mechanism of action of NAM was inhibition of the TGF-β pathway and overall reduction of inflammation. This...
    • haidut
    • Thread
    • eyes fibrosis inflammation niacinamide prevent treat vitamin b3
    • Replies: 5
    • Forum: Scientific Studies
  5. haidut

    Aspirin - A New Osteoporosis Drug

    A study published almost a decade ago made the bold claim that aspirin may be a novel drug for osteoporosis. [Effect of aspirin administration for the treatment of osteoporosis in ovariectomized rat model]. - PubMed - NCBI However, the study did not get much traction and was in fact mocked by...
    • haidut
    • Thread
    • aspirin bmd bone inflammation osteoporosis prostaglandins therapeutic treat
    • Replies: 12
    • Forum: Scientific Studies
  6. haidut

    Asthma Is Driven By Endotoxin And Its Receptors (TLR4, TLR5)

    Yet another study demonstrating the crucial role of the endotoxin/LPS (and its sentinel receptors) in a chronic idiopathic condition - in this case asthma. The cause of asthma is, as usual, officially claimed to be unknown but it is known that asthma can be exacerbated by environmental pollution...
    • haidut
    • Thread
    • asthma cause endotoxin inflammation lps pollution tlr4 tlr5
    • Replies: 9
    • Forum: Scientific Studies
  7. haidut

    Stress (cortisol) Can Cause ANY Autoimmune Condition By Disrupting Gut Barrier

    A great new study that is not afraid to point out the paradox between mainstream medicine's claims of beneficial effects of cortisol and the reality of "autoimmune" conditions more often than not being associated with elevated levels of CRH, ACTH and cortisol. The role of CRH as a causative...
    • haidut
    • Thread
    • autoimmune cause cortisol endotoxin inflammation leaky gut lps ptsd stress
    • Replies: 6
    • Forum: Scientific Studies
  8. md_a

    How Chronic Fear Results In Hypoxia In Tissues And Cancer In Humans Through Bohr Effect

    How Chronic Fear Results In Hypoxia in Tissues and Cancer in Humans through Bohr Effect Professor Sir Sorush Niknamian; Dr. Somayeh Zaminpira Fear is a number of chain reactions in the brain that occurs when one encounters a potentially harmful stimulus. The amygdala is the part of the brain...
  9. haidut

    How Chronic Stress (cortisol) Causes Disease

    Back in 2018 I did a post on a neat study that demonstrated how the presence of cellular (mitochondrial) fragments in the blood stream acts identically to the pituitary hormone ACTH and as such activates the HPA axis. The more cellular fragments are in the bloodstream the more intense the stress...
    • haidut
    • Thread
    • adrenal cellular cortisol debris disease hpa inflammation intact mitochondria plasma serum stress
    • Replies: 0
    • Forum: Scientific Studies
  10. haidut

    Elevated ESR And HCG Levels Are Strong Predictors Of Impending Cancer Diagnosis

    I am posting this study for two reasons. One of them is to corroborate a statement from Peat on the role of inflammation in cancer and the diagnostic value of "non-specific" (as the medical industry likes to call them) inflammatory biomarkers such as erythrocyte sedimentation rate (ESR)...
    • haidut
    • Thread
    • biomarker cancer diagnosis esr hcg inflammation predict reliable tumor
    • Replies: 9
    • Forum: Scientific Studies
  11. Tristan Loscha

    NEW CAFETERIA DIET IS THE OLD SAD DIET

    Cafeteria Diet Is a Robust Model of Human Metabolic Syndrome With Liver and Adipose Inflammation: Comparison to High-Fat Diet Brante P. Sampey,1 Amanda M. Vanhoose,2 Helena M. Winfield,3 Alex J. Freemerman,1 Michael J. Muehlbauer,3 Patrick T. Fueger,4 Christopher B. Newgard,3 and Liza Makowski1...
  12. haidut

    Endotoxin Has A G.E.L.D.I.N.G Effect, Causes Obesity And Hypogonadism

    A very interesting study proposing that the decline in gonadal function seen in obese/diabetic men is due to chronically elevated endotoxin levels in such people. The study calls this phenomenon (G)ut (E)dotoxin (L)eading to a (D)ecline (I)n (G)onadal function (GELDING) due to the remarkable...
    • haidut
    • Thread
    • castration diet endotoxin gelding high-fat hypogonadism inflammation leydig lps obesity tlr tlr4
    • Replies: 34
    • Forum: Scientific Studies
  13. haidut

    PUFA And Serotonin Promote Each Other, And Likely Cause Mental Illness

    I neat new study that draws a direct parallel between PUFA-driven inflammation, serotonin and depression. As the study demonstrated, high levels of the PUFA arachidonic acid (AA) are highly correlated with lower density (expression) of the serotonin transported (SERT, 5-HTT), and the...
    • haidut
    • Thread
    • 5-ht 5-htt bipolar depression inflammation mental illness pufa serotonin serotonin transporter sert suicide
    • Replies: 4
    • Forum: Scientific Studies
  14. haidut

    CamphoSal - Liquid Camphoric Acid + Salol

    As many readers know, Peat has written extensively on the benefits of antibiotics and on keeping the GI tract as free of bacteria as possible. Bacterial overgrowth in the colon alone is already a problem due to the production of endotoxin, but in hypothyroid people this bacterial overgrowth can...
    • haidut
    • Thread
    • antibiotic antiseptic camphoric acid camphosal digestion disinfectant dysbiosis endotoxin fermentation gut flora inflammation intestine lps microbiome phenyl salicylate salol sibo
    • Replies: 440
    • Forum: IdeaLabs
  15. Tristan Loscha

    High-Salt Augments Aldosterone Toxicity Despite Lowered Plasma-Readings

    High-Salt Augments Aldosterone Toxicity Despite Lowered Plasma-Readings. Blood-LVL-Aldosterone gets lowered by sodium,but apparently sensitivity rises,augmenting damage.Sodium is truly almost a micronutrient,with intakes as low as 500mg-1500mg,in indigenous tribes,lower than magnesium,lower...
    • Tristan Loscha
    • Thread
    • aldosterone autoimmune disease chloride cns dementia hypertension inflammation reference range salt sodium toxicity
    • Replies: 77
    • Forum: Debate
  16. haidut

    Vitamin E Restores Cardiac Health After Heart Attack

    A great study that gives vitamin E a much deserved exposure in mainstream media. A few years ago, vitamin E was lambasted by the press for failing to prevent prostate cancer and heart attacks. Yet, upon a more careful look, it quickly becomes evident that those trials were handicapped from the...
    • haidut
    • Thread
    • alpha tocopherol damage fibrosis heart heart attack heart muscle inflammation ischemia lessen prevent scarring tocopherol vitamin e
    • Replies: 4
    • Forum: Scientific Studies
  17. haidut

    Serotonin (due To Bacteria) Is The Master Regulator Of Metabolism, Insulin Sensitivity, And Weig

    Over the last year I posted a number of studies demonstrating strong link between serotonin and chronic conditions such as obesity, insulin resistance, and even diabetes. Augmented capacity for peripheral serotonin release in human obesity...
    • haidut
    • Thread
    • 5-ht bacteria colon diabetes gut inflammation insulin resistance microbiome obesity pathological serotonin sibo tph
    • Replies: 31
    • Forum: Scientific Studies
  18. Tristan Loscha

    Study:Normal To High NaCl Intake Is Associated WithPsoriasis, CNS-Disorders,IL17

    These Data-Hamsters are unhinged,let them entertain us though.Allegedly excess NaCl and concomitant rise of Sodium sensing Glucocorticoid-Kinase1,Interleukine liberation,NFKB induction etc, is a major driver of inflammation. Link To Full...
    • Tristan Loscha
    • Thread
    • autoimmune catabolic cortisol cytokine inflammation neurology psychiatry salt sodium stress
    • Replies: 7
    • Forum: Sodium
  19. haidut

    Allopregnanolone As A Treatment Of Alzheimer Disease (AD)

    It looks like the recent FDA approval of allopregnanolone (ALLO) for postpartum depression may open the floodgates to ton of new research with this steroid, as well as with its reliable precursors such as pregnenolone and progesterone. I posted several studies in the past demonstrating that...
    • haidut
    • Thread
    • ad allo allopregnanolone alzheimer's endotoxin energy inflammation lps metabolism pregnenolone progesterone tlr tlr4 treatment
    • Replies: 0
    • Forum: Scientific Studies
  20. haidut

    Chronic Nerve Pain May Be Caused By Endotoxin, Commercial Food, And Pharma Drugs

    I posted a few threads last year demonstrating that some cases of chronic nerve pain may be caused by a side effects of opioids - activation of TLR4. However, that study only looked at why certain patients using opioids for severe pain go on to develop chronic pain of phantom origin. As such...
    • haidut
    • Thread
    • commercial food endotoxin iatrogenic inflammation lps lysozyme nerve pain neuropathy pharmaceutical drugs tlr tlr4
    • Replies: 5
    • Forum: Scientific Studies
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