inflammation

  1. haidut

    Methylene Blue Is A Potent Anti-inflammatory, With Possibly The Broadest Spectrum

    Some bold statements in this study, which combined both in vitro and in vivo models. The HED for methylene blue (MB) was just 0.15mg/kg, which is in the range of 10mg-15mg doses that showed great effectiveness in treating mental disorders like depression and psychosis. As you can see from the...
  2. haidut

    Dietary Stearic Acid Reduces Visceral Fat By 70% And Increases Lean Mass

    This is a study that @Travis will probably like a lot. Stearic acid is one of the SFA that are considered anti-inflammatory even by mainstream science. It has pronounced anti-tumor effects in various cancer models, and one of the proposed mechanisms was its ability to reduce fat deposits. The...
  3. haidut

    Without Endotoxin (TLR4), An HIV Infection May Not Cause AIDS

    More than 3 years ago I posted a study showing that monkeys that are natural carriers of the simian version of HIV known as SIV, do not develop AIDS. It was only after being injected with endotoxin (even when attenuated) that these monkeys develop the wasting syndrome and oppostunistic...
  4. haidut

    Alcohol Mostly Benign For The Liver, Causing Injury Requires Endotoxin (LPS)

    Peat wrote in one of his articles that alcohol is getting a bad reputation for causing all sorts of liver disease and even liver cancer, but alcohol by itself is fairly neutral for the liver and that the role of PUFA, iron and endotoxin is being neglected by mainstream medicine. The study below...
  5. haidut

    Chronic Fatigue Syndrome (ME/CFS) May Be Caused By Increased Serotonin Sensitivity

    Despite the denials of mainstream medicine that CFS exists as an organic disorder, many studies have been done on the etiology of the fatigue and how it often follows an acute illness, usually of "viral" origin. Due to the fact that the role of serotonin in inducing fatigue is well-known...
  6. haidut

    The Brain Damage In Cases Of TBI May Be Partially Driven By Gut Bacteria

    Traumatic brain injury (TBI) is one of the most common injuries sustained by soldiers on the battleield, as well as by various athletes (NFL, NHL, major league soccer, etc). Repeated TBI events or even a single TBI of sufficient severity can trigger what is commonly known as chronic traumatic...
  7. haidut

    Glycine Is Directly Anabolic AND Anticatabolic For The Muscle

    I posted a few interesting studies about glycine in the past. Among the interesting properties are lowering cortisol, increasing DHT synthesis, improving insulin sensitivity, and serving as a biomarker of stress. Glycine Powerfully Lowers Cortisol Glycine Strongly Upregulates 5-alpha Reductase...
  8. haidut

    Estrogen Causes Asthma; Progesterone, T, DHT, And DHEA Are Protective

    Most of the forum members probably know that the incidence of "autoimmune" conditions is much higher in women then in men. This fact gets consistently ignored by doctors working in the field as a mere fluke, or due to "unknown hormonal interactions" which are nonetheless deemed not causative of...
  9. haidut

    Endotoxin (LPS) Theory Of Atherosclerosis (CVD)

    I posted a study more than year ago, which examined the role of NO in aging and disease. The Nitric Oxide (NO) Theory Of Aging One of the main endogenous stimulators of NO synthesis is endotoxin (LPS). It turns out that the connection between LPS and CVD has been studied for a long time in...
  10. haidut

    Vitamin E May Prevent/treat Asthma

    I think this study is very important simply because currently there are no truly safe treatments for asthma AND the study was conducted on humans. As many forum users have seen on TV ads, virtually all drugs for asthma control increase the risk of death related to asthma. In some cases the onset...
  11. haidut

    Breast Implants Can Cause Lymphoma

    The study only discussed one specific type of localized lymphoma but the underlying cause (inflammation) is generic enough for me to wonder how many other cancer are caused by breast implants. At least the message is loud and clear that it was inflammation due to the body trying to contain the...
  12. M

    Vegetable Oils Make You Fat And Cause Chronic Disease

    For anyone who’s looked into and reasearched the health effects of different omega-6 containing vegetable oils, you’ll quickly find that there’s a strong connection between all of them and the major degenerative diseases such as diabetes, cancer, heart disease, alzheimer’s and even obesity...
  13. haidut

    Sunlight And Aspirin Can Treat Multiple Sclerosis (MS)

    The link between sunlight exposure and incidence of MS is well-known and strongly pointed to a metabolic origin of the disease as early as the 1960s. It led to a few underpowered trials with low dose vitamin D, which did not find much benefit. However, a recent trial with a higher dose (10,000...
  14. P

    Histamine Suppresses Epidermal Keratinocyte Differentiation And Impairs Skin Barrier Function In A H

    Histamine suppresses epidermal keratinocyte differentiation and impairs skin barrier function in a human skin model Abstract Background Defects in keratinocyte differentiation and skin barrier are important features of inflammatory skin diseases like atopic dermatitis. Mast cells and their...
  15. haidut

    C. Difficile Gut Infection Or Even IBD May Be Due To Low Vitamin D Or PPI Drugs

    As the study says, the direct cause is high intestinal levels of calcium but as the study also says these are usually due to poor calcium absorption. And unless a person has IBD (which is rare) the low vitamin D status or PPI drug (GERD) use stand out as the most likely causes, even more so...
  16. haidut

    DeFibron - Liquid Methylated SFA For Lab/R&D

    Ever since I read in one of Ray's articles about the ability of saturated fat to reverse even advanced liver fibrosis (cirrhosis) I have been researching the effects of various saturated fatty acids on a number of organs and tissues. A number of studies have been posted on the forum indicating...
  17. haidut

    Candida Overgrowth Is A Major Factor In (alcoholic) Liver Damage / Cirrhosis

    Over the last 5 years or so it has become very fashionable among many "naturopaths" to throw the diagnosis "Candida overgrowth" at every symptom of gut dysfunction people present with at the doctor. Peat has spoken about Candida overgrowth and how the fungus typically only becomes an issue in...
  18. Diokine

    Disruption Of Nerve Functioning Is A Necessary Factor In Progression Of Inflammatory Conditions

    Metabolism can be roughly viewed as a set of timed processes, with many dimensions between the degrees of timing. This is a fairly mechanistic view of what is happening, but will allow us to think about how disruptions in the timing can lead to changes in the system. Many different biological...
  19. haidut

    Aspirin (but Not Other NSAID) Treats Barrett’s Esophagus And Possibly GERD

    The good news for aspirin just keep on coming. I posted a few studied in the past about GERD and its progressions Barrett’s esophagus, and esophageal cancer being caused by inflammation and not stomach acid. As such, PPI drugs are probably useless for treating and preventing GERD (since they...
  20. haidut

    CNN: Saturated Fat Does NOT Clog Your Arteries; Stress And Inflammation Do

    I think we will be seeing more and more of these "breaking news" on major news outlets as the house of cards made of PUFA slowly crumbles. The FDA already reversed its official recommendations on cholesterol, but left the policies on saturated fat intact even though the same study on which the...
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