hypoxia

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    Hypoxic chambers may cause myocardial repair after a heart attack

    Abstract Background: Oxygen supplementation in myocardial infarction (MI) remains controversial. Inflammation is widely believed to play a central role in myocardial repair. A better understanding of these processes may lead to the design of novel strategies complementary to MI treatment...
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    Elevating the level of hypoxia inducible factor may be a new potential target for the treatment of depression

    فاکتور 1 القایی هیپوکسی (HIF-1) یک فاکتور رونویسی است که بیان ژن را در پاسخ به کاهش سطح اکسیژن در بافت یا هیپوکسی تنظیم می کند. HIF-1 با واسطه در متابولیسم میتوکندری و در نتیجه کاهش استرس اکسیداتیو اثرات محافظتی در برابر هیپوکسی اعمال می کند. اخیراً، افزایش سطح استرس اکسیداتیو و متابولیسم...
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    Hypercapnia-inducible factor: a hypothesis | Aging and longevity

    Abstract Cells and tissues sense and respond to hypercapnia by global activation or down-regulation of hundreds of genes and switching on/off a number of signaling and metabolic pathways. We hypothesize for the first time that such complex rearrangements are hardly possible without subtle...
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    Bajau People - Seaborne lifestyle

    These people are known for their exceptional abilities in free-diving. They spent on average 5 hours a day in the sea and mostly underwater trying to hunt fish. Previously, I have read some articles regarding health benefits of regular physical activity in water. So when I saw info about the...
  5. haidut

    Hypoxia, Nutrient Deficiency Rapidly Rewires Cells For Cancer Metabolism

    One of the earliest observations of Otto Warburg when he studied cancer was that anything that interferes with oxygen supply to the cell effectively caused the cell to become "cancerous". In other words, he opined that cancer was essentially an adaptation to a lack of oxygen, not a mutant gory...
    • haidut
    • Thread
    • cancer deficiency glycolysis hif hypoxia metabolism nutrient oxygen rewire starvation warburg effect yme1l1
    • Replies: 2
    • Forum: Scientific Studies
  6. haidut

    Fatty Acid Oxidation (FAO) Makes Cancer Therapy-resistant, Niacinamide May Help

    Yet another study that shows FAO playing a crucial role in cancer progression. As many forum users know, anti-angiogenic therapies are one of the cornerstones of current cancer treatments. This therapy typically uses the so-called VEGF inhibitors to block the formation of new blood vessels in...
    • haidut
    • Thread
    • angiogenesis cancer cpt1 fatty acid oxidation hypoxia inhibitor lipolysis metastasis mildronate niacinamide progression tumor vegf
    • Replies: 0
    • Forum: Scientific Studies
  7. haidut

    Estrogen As The Main Cause Of Cancer And Its Progression

    I think many of the forum users here know about the infamous study that generated a lot of controversy on "scientific" forums like Reddit. It basically showed that the Warburg Effect (overproduction of lactate) is not just an effect but a direct cause of cancer. So, as the top rated comment on...
    • haidut
    • Thread
    • cancer estrogen estrogen receptor fatty acid oxidation glycolysis hif hif-1 hypoxia lactate lactic acid mitochondria nad/nadh pdh pdk pyruvate randle cycle redox homeostasis warburg cause warburg cycle warburg effect
    • Replies: 18
    • Forum: Scientific Studies
  8. haidut

    Even Wikipedia Says That Water Inside The Organism Has Structure

    Peat and Ling have written at length about the effects of various substances on water structure both inside and outside the cell and how that affects tissue oxygenation and metabolism. However, the idea is considered heretical in scientific circles. I have a few friends who are doctors or work...
    • haidut
    • Thread
    • cancer crocetin hydrophobic hypoxia ldh metabolism oxygenation structure water
    • Replies: 7
    • Forum: Scientific Studies
  9. haidut

    Hypoxia Causes Hypermethylation And Cancer Progression; Can Be Reversed

    The dangers of hypermethylation have been discussed by Peat in many of his articles and interviews. Some of the supplements and foods he has recommended in the past are known methyl group acceptors/depletors and this probably explains a good deal of their beneficial effects. Niacinamide, glycine...
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    Effects Of Hypoxia On Testosterone Release In Rat Leydig Cells

    Effects of hypoxia on testosterone release in rat Leydig cells. - PubMed - NCBI The aim of this study was to explore the effect and action mechanisms of intermittent hypoxia on the production of testosterone both in vivo and in vitro. Male rats were housed in a hypoxic chamber (12% O(2) + 88%...
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    Methylene Blue Protection Against Hypoxic Injury In Primary Cultures Of Rat Hepatocyte Monolayers

    Methylene blue protection against hypoxic injury in primary cultures of rat hepatocyte monolayers. - PubMed - NCBI Mitochondrial respiration is inhibited in cells exposed to hypoxia, and the oxidation of NADH to NAD(+) is blocked. As a result, oxidation reactions requiring NAD(+) are blocked...
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    Hypoxia As A Therapy For Mitochondrial Disease

    Hypoxia as a therapy for mitochondrial disease. - PubMed - NCBI Defects in the mitochondrial respiratory chain (RC) underlie a spectrum of human conditions, ranging from devastating inborn errors of metabolism to aging. We performed a genome-wide Cas9-mediated screen to identify factors that...
  13. haidut

    Hypoxia Biomarker HIF-1 Is A Master Inhibitor Of Metabolism

    In another confirmation of Peat's ideas, this human study demonstrates that hypoxia, through increased levels of HIF-1 directly inhibit oxidative metabolism and activate the enzyme pyruvate dehydrogenase kinase (PDK). PDK inhibits the oxidation of pyruvate by inhibiting the enzyme pyruvate...
  14. haidut

    Inhibiting Hypoxia Biomarker (HIF-1) Reverses Parkinson Disease

    Ray has written a lot about HIF-1 and its role in cancer and heart disease. It looks like this biomarker of hypoxia is implicated in the energetic deficits underlying Parkinson disease. Blocking HIF-1 reversed the Parkinson pathology. Caffeine, methylene blue, aspirin and CO2 all inhibit the...
  15. haidut

    PUFA Causes Hypoxia And Hypoxia ALWAYS Causes Cancer

    Fairly recent study, with a good review of the role of PUFA in the hypoxia that, if maintained chronically, always leads to cancer. Chronic cellular hypoxia as the prime cause of cancer: what is the de-oxygenating role of adulterated and improper ratios of polyunsaturated fatty ... - PubMed -...
  16. haidut

    Oxygen breathing acutely raises prolactin in humans

    Ray has written on the dangers of hyperoxia and its inability to actually increase tissue oxygenation. Now it looks like there is another danger of inhaling pure O2 - raised prolactin. It also looks like hyperoxia increased prolactin more than hypoxia. So, even more reason to raise our CO2 since...
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