hpa

  1. haidut

    Childhood stress causes mental illness in adults by blunting androgens

    Yet another great study solidifying the evidence on just how detrimental early childhood stress is. It has been known for decades that childhood stress leads to early puberty, and that the latter is associated with greatly increased risk of chronic diseases later in life, as well as early death...
  2. haidut

    Stress (cortisol) as the driver of hyperglycemia in type II diabetes

    To most of my readers, the title of the post may seem like something completely obvious and not deserving explanation of clarification. However, according to mainstream medicine (until now, at least) cortisol does not really have a causative role either in the development of diabetes type II or...
  3. haidut

    Sexual activity and stress levels (HPA activity) may determine longevity

    The study below tried to tease out the main factors affecting the longevity of the legendary naked mole rat - the animal with longest lifespan in its genus, and the sole mammal known to be virtually immune to developing cancer. Most of the biological/biochemical findings in regards to naked mole...
  4. haidut

    Studies In Animals Often Use Stressful Methods That Produce Invalid Results

    Back in 2012, when I first started writing about the benefits of steroids such as pregnenolone, I often got emails quoting the study below as evidence that pregnenolone and related steroids amplify instead of mitigate the stress response (HPA axis). Neuroactive steroids modulate HPA axis...
  5. haidut

    How Chronic Stress (cortisol) Causes Disease

    Back in 2018 I did a post on a neat study that demonstrated how the presence of cellular (mitochondrial) fragments in the blood stream acts identically to the pituitary hormone ACTH and as such activates the HPA axis. The more cellular fragments are in the bloodstream the more intense the stress...
  6. P

    Evidence For Brain Sensing Of Circulating FFA

    A Fall in Plasma Free Fatty Acid (FFA) Level Activates the Hypothalamic-Pituitary-Adrenal Axis Independent of Plasma Glucose: Evidence for Brain Sensing of Circulating FFA Endocrinology. 2012 Aug; 153(8): 3587–3592. Published online 2012 Jun 1. doi: 10.1210/en.2012-1330 PMCID: PMC3404348...
  7. haidut

    Insulin Resistance As An Endocrine Disorder

    This argument has flared up so many times on this forum and I doubt we have reached any agreement. I am on the side that insulin resistance and obesity are endocrine disorders. There is a group here that maintains that it is the obesity that really triggers it all. This study discusses some of...
  8. haidut

    The Antidepressant Mechanism Of Androsterone

    There is solid evidence that androgens have potent antidepressant effects in both sexes. However, the mechanism of action of that antidepressant effect has not been fully elucidated yet. On the other hand, it is also well known that chemicals that increase the levels of the so-called...
  9. haidut

    Pregnenolone As A Treatment For Loneliness

    I touched upon this idea/topic in some of my other posts, and just like those other posts, I would like to emphasize here that I am not suggesting steroid supplementation as a substitute for social interaction. The purpose of this post if to provide some insight on the biochemical effects of...
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