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glycolysis

  1. haidut

    The "cancer metabolism" drives aging in humans

    A truly monumental study, as it is perhaps the first one to demonstrate that "aging" in human cells is entirely under metabolic control. What can I say - Ray Peat right again! Unfortunately, the way the actual study has been worded has been, once again, criminally mis-represented by mainstream...
  2. Limon9

    Coffee Diterpenes Have A Metformin-Like Anti-Diabetic Action

    My previous post highlighted the pathological mTOR-mediated aerobic glycolysis caused by endotoxin, so I thought it should be balanced with an example of glycolysis-boosting when oxidative phosphorylation is unimpaired. The experiment looked both in vitro and in vivo at the effects of kahweol, a...
  3. Limon9

    MTOR Activates Warburg Effect From Endotoxin

    As Dr. Peat referred to in his newsletters, it's no surprise that a cell-proliferative enzyme activates aerobic glycolysis. Oxidative energy production is halted so the cells may regress to a primitive growth-state. Inhibiting either mTOR or the glycolytic enzyme it upregulated was sufficient to...
  4. PeskyPeater

    Why Dr Peat advises to use DHEA Progesterone to grow hair

    Goodday! I can now begin to see why Dr Peat advises to use DHEA with Progesterone to grow hair. The DHEA get's metabolized towards E1 Estrone ( and or E2 ) [6] which support the glycolytic 'cancerous like' state of hair growth that uses glutamine and glucose as a source that convert to...
  5. A

    Lactate dehydrogenase inhibition increases osteogenic potential

    Cellular bioenergetics is a promising new therapeutic target in aging, cancer, and diabetes as these pathologies are characterized by a shift from oxidative to glycolytic metabolism. We have previously reported such glycolytic shift in aged bone as a major contributor to bone loss in mice. We...
  6. haidut

    Niacinamide may treat ALS by improving energetic state

    Another study sent to me by the Austrian collaborator. Once again, the energetic origin of "incurable" diseases like amyotrophic lateral sclerosis (ALS) is on full display. The study elucidates that ALL types of ALS are characterized by metabolic/energetic abnormalities and the metabolic...
  7. haidut

    Cytokine Storm In COVID-19 / Sepsis Due To "cancer Metabolism" (Warburg Effect)

    A great study illustrating the crucial effects of metabolism even in "non-metabolic" conditions like COVID-19. We already have evidence that increased PUFA peroxidation is one of the causes behind the (often lethal) cytokine storm in viral diseases, including COVID-19. However, the direct...
  8. haidut

    Hypoxia, Nutrient Deficiency Rapidly Rewires Cells For Cancer Metabolism

    One of the earliest observations of Otto Warburg when he studied cancer was that anything that interferes with oxygen supply to the cell effectively caused the cell to become "cancerous". In other words, he opined that cancer was essentially an adaptation to a lack of oxygen, not a mutant gory...
  9. haidut

    ALS Tied To Increased Fat Oxidation (FAO), Increasing Glucose May Treat It

    I made a few posts in the past about ALS characterized by adrenal hyperactivity and suppressed gonadal function, as well as mitochondrial dysfunction and copper deficiency. Also, non-familial ALS is known to occurs 4-5 times more often in active/retired elite athletes. All of these findings...
  10. haidut

    Baking Soda May Treat Cancer, Metformin May Cause It

    As many readers know, using baking soda to treat cancer has been labelled as "quack medicine" by many official mouthpieces of mainstream medicine, as well as by several "watchdog" groups. Here are some links "debunking" the usage of baking soda for cancer...
  11. haidut

    Estrogen As The Main Cause Of Cancer And Its Progression

    I think many of the forum users here know about the infamous study that generated a lot of controversy on "scientific" forums like Reddit. It basically showed that the Warburg Effect (overproduction of lactate) is not just an effect but a direct cause of cancer. So, as the top rated comment on...
  12. haidut

    Inosine Powerfully Stimulates Mitochondriogenesis, Oxidative Metabolism & Cell Differentiation

    Yet another absolutely great study on inosine. It shows that not only can inosine replenish ATP (as shown in the previous studies I posted) but it can inhibit excessive glycolysis, lower lactate, and dramatically improve oxidative metabolism - effects which are key driver of cell differentiation...
  13. haidut

    Metabolism May Be Older Than Life Itself And Can Start Spontaneously

    If this is indeed true I am not sure how can modern medicine continue to deny the primary role of metabolism in the human organism. The picture so far suggests that metabolism appeared first, then RNA and finally DNA. The same group published two studies. The first one showed that glycolysis can...
  14. haidut

    Blocking Glycolysis May Be A Treatment For Lupus

    Yet another disease likely to be metabolic in origin. In an animal model scientists seemingly cured lupus by blocking glycolysis and also mitochondrial metabolism of specific immune system cells. Given that the drug used to block mitochondrial metabolism was metformin, it is yet another reason...
  15. haidut

    Glycerol Extends Lifespan By Inhibiting Glycolysis

    Ray has written several times about calorie restriction and I am a bit confused on his views. On one end he says that restricting calories enhances metabolism, on the other hand he says it is bad b/c it lowers thyroid hormone and promotes fatty acid oxidation, which is a hallmark of stress...
  16. haidut

    Cancer Debate May Be Finally Over, Confirming Ray's Views Again

    This is all over the scientific forums, including sites like Reddit. The bottom line is this - after about 100 years of denial, modern science finally seems to be admitting that the Warburg Effect is a cause of cancer and not just a result/symptom/sign. The study goes on to discuss how...
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