glycine

  1. haidut

    Glycine Can Completely Prevent Esophagus Damage Caused By GERD

    As discussed in another thread by forum member @denise, using PPI drugs is really to no benefit for preventing inflammation of the esophagus and subsequent development of Barret's or even cancer. The GERD damage is based on an inflammatory reaction, as I mentioned in another post. As such, it...
  2. haidut

    5α-Dihydroprogesterone (5α-DHP) - The Primary Progestogen Neurosteroid

    It has been shown that progesterone rapidly metabolizes into more saturated metabolites such as 5α-Dihydroprogesterone (5α-DHP) and tetrahydroprogesterone (also known as allopregnanolone or Allo). The enzyme 5-AR is the one responsible for the saturation, just as it is responsible for the...
  3. haidut

    Low-dose Glycine As Stroke Treatment In Humans

    The mainstream therapy for (non-hemorrhaging) stroke is a IV anticoagulants like warfarin, or a baby aspirin within the first few hours of getting stroke symptoms while the person is on her/his way to the hospital. These two studies show that sublingual glycine in a dose of 1g-2g within the...
  4. haidut

    Low-dose Glycine May Treat Alcoholic Delirium / Hallucinosis In Humans

    The symptoms of alcohol withdrawal and its associated delirium are due mostly to serotonin overload and functional GABA deficiency. As such, anti-serotonin drugs can be very beneficial but they often have side effects and cannot be freely obtained. This human study showed that a single...
  5. haidut

    Glycine Is An Endotoxin (TLR4) Antagonist

    We can now add glycine to the substances that inhibit endotoxin or its effects. The endotoxin antagonism probably explains a good deal of glycine's protective effects on the liver from all sorts of assaults, but especially ethanol/alcohol (which is a known TLR4 agonist). The in-vivo study used a...
  6. haidut

    Glycine May Treat Type II Diabetes In Humans

    Human study, with a moderate dose of glycine. Ray wrote several times about the usage of gelatin as treatment for even type I diabetes. Unfortunately, the practice was abandoned in the early 20th century in favor of more toxic therapies or insulin injections. This human study shows that a...
  7. haidut

    Glycine Protects From Iron Toxicity In The Liver

    The optimal approach would be to keep iron stores on the low end of normal but for the people who already have confirmed iron overload, this study may offer some help. Glycine seems to protect from the toxicity of iron, which is mainly manifested in the liver (and sometimes brain). Iron induces...
  8. U

    Oral Administration Of Glycine Increases Extracellular Serotonin But Not Dopamine In The Prefrontal

    Abstract AIM: Glycine, one of the non-essential amino acids, has been reported to be effective in reducing negative symptoms of schizophrenia. Recently, we found that glycine improves subjective sleep quality in humans. The aim of this study was to investigate the effects of oral glycine...
  9. P

    Is Insulin Resistance A Result Of Impaired Beta Oxidation Or Excessive Beta Oxidation?

    Peat's obviously a big believer that healthy glucose metabolism should be favored over beta oxidation, and that many factors, including PUFA, excessive lypolysis, serotonin, estrogen, cortisol, lactate, and inflammation all steer the body away from oxidative metabolism, leading to even more...
  10. haidut

    Pregnenolone Activates The Glycine Receptor

    This mechanism of pregnenolone is one of the proposed methods through which it enhances neurogenesis, memory, mood and even motor function. Low doses pregnenolon improve sleep quality and are even mildly sedating, which may also be due to the activation of the glycine receptor. Subunit-specific...
  11. haidut

    RoundUp (glyphosate) Linked To Alzheimers, Parkinson And ALS

    I posted about a similar study a few months ago, but this time the scientists are directly making the claim that RoundUp is causally involved with these conditions. The mechanism of action is again glycine antagonism / deletion by glyphosate. Monsanto's Roundup Weedkiller Linked to Alzheimer's...
  12. haidut

    RoundUp (Glyphosate) Finally Proven Toxic - It Depletes Glycine

    For more than 2 decades Monsanto has been denying that RoundUp has a provable adverse effects on living organisms. The official reason cited was that there was no known mechanism through which glyphosate (active ingredient in RoundUp) can exert detrimental effects on the cell. Sounds...
  13. haidut

    Low-dose Glycine As A Treatment For Menopause, Osteoporosis, Obesity

    This study is a great find IMO but unfortunately it uses the elevations in blood levels of estrogen as a reason to label glycine as estrogenic, which is wrong. Just like progesterone, glycine can trigger release of estrogen from tissues/cells and this elevates the blood levels while lowering it...
  14. haidut

    Glycine Powerfully Lowers Cortisol

    I have long suspected that inhibitory amino acids suppress cortisol release. The reason is that most of these inhibitory amino acids like glycine, taurine, beta alanine, theanine, etc are all GABA agonists. GABA agonist pharma drugs are used to treat Cushing syndrome and are very effective at...
  15. haidut

    Glycine Lowers Tsh

    This study adds to the evidence that glycine is pro-thyroid and thus anti-stress. A single relatively low (human equivalent) dose of 600mg - 1,500mg blunted the increase of TSH due to stress. Notably, the low HED dose of ~7mg/kg was the most effective, which means 500mg - 700mg is all that is...
  16. haidut

    Glycine Strongly Upregulates 5-alpha Reductase (5-ar) Activity

    This is study is a great find in my opinion. It is well known that conditions like depression and dementia are associated with reduced levels of the neurosteroid allopregnanolone. A few of the successful SSRI drugs like Prozac have the "side effect" of increasing levels of allopregnanolone in...
  17. Nicholas

    Conditionally Essential Amino Acids: Glycine And Arginine

    regarding Lysine overdosage: http://www.ncbi.nlm.nih.gov/pubmed/15204731 "A Lys-related drop in serum concentration and an increase in urine excretion of chlorides was a compensatory reaction to the ingested hydrochloride. No functional, biochemical, or histological changes in renal function...
  18. haidut

    Glucose has the same effect on the brain as glycine

    Related to the other study on glucose I posted minutes ago. This study shows that just like glycine, taurine, and beta alanine glucose is a glycine "receptor" agonist. As such, it has an inhibitory effect on the brain and spinal cord and likely has similar effects to glycine on variety of...
  19. Y

    Glycine - Prototombin Time?

    Hello, I know Glycine has antiplatelet (aggregation) properties, for example here: http://link.springer.com/article/10.100 ... 012-1422-8 which is supposed to increase clotting time. Now on a Milk thistle thread on this forum: http://raypeatforum.com/forum/viewtopic.php?t=5942 there is a...
  20. haidut

    Glycine As Prevention And Treatment For Cancer

    Related to my recent post on PUFA carcinogenicity and its prevention by dietary glycine, this study makes a case for using glycine as a general method of preventing and potentially treating cancer. Glycine is one of the most potent inhibitors of VEGF and many of the current blockbuster drugs are...
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