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The study discussed here presents evidence that clearing the body of the fat byproducts glycerol and glyceraldehyde could lead to an increased lifespan.
In light of those data, a supplement that comes to mind is dihydromyricetin, which causes the body to produce more alcohol dehydrogenase and...
-manganese increases co2 production from glucose
Regulation of glucose utilization and lipogenesis in adipose tissue of diabetic and fat fed animals: effects of insulin and manganese. - PubMed - NCBI
Ray has written several times about calorie restriction and I am a bit confused on his views. On one end he says that restricting calories enhances metabolism, on the other hand he says it is bad b/c it lowers thyroid hormone and promotes fatty acid oxidation, which is a hallmark of stress...