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An interesting study, which not only exposes yet another negative side of estrogen but also demonstrates the opposing actions estrogen and progesterone have on the brain. The former is excitatory (by activating the glutamate system and inhibiting the GABA system) while the latter does the exact...
Progesterone increases glutamate in the brain via blocking GAD enzyme
Progesterone increases glutamate in the brain via blocking GAD enzyme activity, this can lead to overexcitation and depression via glutamate excess.
From the start the use of Progesterone felt bad to me and I knew it was...
Fasoracetam might be especially interesting for people that don't react well to the other racetams and stimulants in generel. I've found that phenylpiracetam can make me a bit irritable, but stacking it with something GABAergic alleviated that.
Or people dealing with anxiety, depression...
Hi all,
Just wanted to share the article that I wrote on OCD: OCD: supplements to help overcome it » MenElite
Please feel free to share what you've tried and what has worked for you.
Peat has written many times in his articles about the long-distance communication among cells in a living organism. When a single cell is injured is sends a signal, which if strong enough, can traverse the entire organism. This mechanism is known to occur in animals yet medical science still...
Insulin Neuroprotection and the Mechanisms
Insulin, Neuroprotection, GABA, Glucose, Glycogen, Ischemia, Glutamate
Introduction
Insulin is the only endocrinology hormone to decrease blood glucose. In addition, insulin serves as a growth factor, modulating mitogenesis, growth, and...
Aspirin inhibits stress-induced increase in plasma glutamate, brain oxidative damage and ATP fall in rats. - PubMed - NCBI
The precise mechanisms by which stress induces brain damage are still being elucidated. The high-output, inducible isoform of nitric oxide (NO) synthase (iNOS) is...
Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism
Cancer-associated fibroblasts release exosomes that both deliver nutrients to cancer cells and inhibit oxidative phosphorylation. Exosomes from fibroblasts can supply an amino acid called glutamine and other...
Metabolism of galactose in the brain and liver of rats and its conversion into glutamate and other amino acids. - PubMed - NCBI
Abstract
Time- and dose-dependent measurements of metabolites of galactose (with glucose as control) in various organs of rats are discussed. Not only the liver but...
Rat study, but should be applicable to humans as well. Human equivalent dosage is about 20mg of biotin per day, which may seem very high to some. However, it has been shown to be safe in humans for up to a year administration and incidentally this is the dose used in humans to lower cholesterol...
The study was about SSRI effectiveness prediction, but as usual, sometimes little gems leak out of the study that are useful to people with Peatarian mindset:
http://www.newscientist.com/article/dn2 ... sants.html
"...In the latest study, Turecki and his colleagues measured the levels of about...