fatty acid oxidation

  1. B

    I feel so lost - hair loss as a 26 year old (w/ pictures)

    I have been experiencing immense hair loss since May of this year. Both a receding hairline and intense shedding when I run my fingers through my hair. I have implemented everything under the sun from oysters, aspirin, oxtail, raw liver, methyl blue, cutting training, increasing protein, to...
  2. haidut

    Niacinamide may treat depression by improving energetic state

    A very interesting study, sent to me by a collaborator who lives in Austria. It demonstrated that depression is accompanied by increased SIRT1 activity (i.e. increased fatty acid oxidation), lower ATP levels and redox balance shifted towards reduction. The study demonstrated that animals without...
  3. Ras

    Glycine Ameliorates NAFLD By Modulating FAO, Glutathione Synthesis, And The Gut Microbiome

    Altered the title to make it fit. Glycine-based treatment ameliorates NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome Full text ABSTRACT Nonalcoholic fatty liver disease (NAFLD) including nonalcoholic steatohepatitis (NASH) has reached epidemic...
  4. haidut

    Lipolysis / FFA Drive Breast Cancer By Promoting Estrogen Signalling

    The evidence for the fat-loving nature of cancer just keeps on accumulating. During the last podcast with Danny and Ray, I mentioned that in cancer cells the enzyme fatty acid synthase (FAS) is actually part of the estrogen receptor (ER) complex. As such, anything that increases the...
  5. haidut

    Doxycycline Akin To Meldonium / Mildronate, May Cure Triple-negative Breast Cancer

    Once again, the role of excessive fat oxidation is on full display. While mainstream medicine is slowly and reluctantly admitting that cancer may in fact be a metabolic disease, it still views glucose as the primary oncogenic factor in the diet. Yet, little by little, research demonstrates that...
  6. haidut

    Fatty Acid Oxidation (FAO) Inhibition Abrogates Triple-negative Breast Cancer

    The evidence for the role of excessive FAO in cancer keeps piling on. As many of my readers know, triple-negative breast cancer is one of the most difficult to treat and its proportion of total breast cancer cases has been steadily rising over the last 20 years. When a patient is diagnosed with...
  7. haidut

    Pulmonary Hypertension (usually Fatal) Driven By Increased Fat Oxidation (FAO)

    Most of the forum readers are familiar with the "mysterious" condition pulmonary arterial hypertension (PAH). I put "mysterious" in quotes, because mainstream medicine claims that its cause is unknown, its onset is unpredictable, there is no cure, and females are affected 4-5 times more often...
  8. haidut

    Forcing The Heart To Burn Glucose Instead Of Fat May Cure Heart Failure

    One of the blockbuster studies I have seen over the last 12 months. It reads as if written by Peat himself and discusses tissue regeneration, Randle cycle, dietary control of metabolism, etc. AFAIK this is the first study brave enough to demonstrate that simply switching fuel types in an...
  9. haidut

    Burning More Fat And Less Glucose Leads To Diabetes

    I really hope the keto community and other low-carb diet afficionados are taking note of the stream of recent studies that keep demonstrating a causative link between low-carb and/or high-fat diets, fasting, chronic stress, cortisol and diabetes. The evidence at this point is indisputable, no...
  10. haidut

    Arginine / Glutamine Depletion May Treat Cancer By Blocking The Warburg "Effect"

    As my readers have noticed, I started putting quotes around the "effect" part of the infamous observation made by Otto Warburg himself. Over the last 3-4 years, even mainstream medicine has started to publish studies acknowledging that the "effect" is very much a cause as well. In other words...
  11. haidut

    Inhibiting Fatty Acid Synthesis (FAS) Dramatically Improves Sepsis Survival Rate

    Yet another study that points the finger straight at fat as a key factor in one of the most common causes of inpatient hospital mortality - sepsis. Sepsis is currently considered to be a condition of infectious (bacterial) etiology, driven by endotoxin. However, in light of the new findings it...
  12. haidut

    MS Tied To Glucose Deficiency Due To Endotoxin And Fat, Extra Glucose May Treat It

    Just a few days ago I posted the groundbreaking study on metabolic derangement in ALS - i.e. it is a diseased characterized by increased FAO, which wastes glucose. Simply increasing dietary glucose was able to greatly restrain the pathology...
  13. haidut

    ALS Tied To Increased Fat Oxidation (FAO), Increasing Glucose May Treat It

    I made a few posts in the past about ALS characterized by adrenal hyperactivity and suppressed gonadal function, as well as mitochondrial dysfunction and copper deficiency. Also, non-familial ALS is known to occurs 4-5 times more often in active/retired elite athletes. All of these findings...
  14. haidut

    SIRT1 Is A Key Promoter Of Leukemia And Other Blood Cancers

    SIRT1 (one of the sirtuin genes) is currently one of the stars in the nutritional/medical blogosphere. As far as back as 2004, SIRT1 was promoted as a key regulator of longevity and activating this gene was marketed as one of the most reliable ways of increasing lifespan. Resveratrol was lauded...
  15. haidut

    Increased Fat Oxidation (FAO) Does Not Lead To Weight / Fat Loss

    The study below directly contradicts a mantra commonly repeated in nutrition circles - restrict glucose and increase fat oxidation in order to lose body fat. In fact, this idea is so ingrained into the minds of most people that I often get hate mail from people all over the world angrily...
  16. haidut

    Pyrucet - Liquid (ethyl) Pyruvate/Aceatoacetate Mix

    As many forum users know, I have been interested in the Randle Cycle (glucose/fat competition for oxidation) for quite some time. The topic of limiting fatty acid oxidation (FAO) and promoting glucose oxidation is pretty central to the metabolic theory of health. Peat has written many times on...
  17. haidut

    Saturated Fats (SFA) Increase Glucose Oxidation While PUFA Decrease It

    This is great human study that addresses two key questions people have often asked Peat in regards to SFA vs. PUFA. As Peat has mentioned several times, during stress (exercise in this case) PUFA is preferentially oxidized while SFA is stored. The preferential oxidization of PUFA during stress...
  18. haidut

    Increased Fat Oxidation Is The Cause Of Kidney Damage

    At least in diabetes, according to the study below. Peat mentioned in several of his articles and interviews that the kidney damage so commonly seen in both type I and II diabetes patients is due to increased PUFA oxidation and decreased glucose oxidation. He also said that the same mechanism...
  19. haidut

    Liver Disease Is Caused By Low ATP Driven By Fat (PUFA) Oxidation

    I posted a study several months ago on the ability of inosine to prevent/reverse liver disease, and how liver damage caused by various toxins was due to lower ATP levels in the liver. Inosine, being both a metabolite and precursor of ATP, is able to restore ATP levels and as such to...
  20. haidut

    Sterilizing The Gut Restores Insulin Sensitivity By Reducing Fatty Acid Oxidation

    I am posting this study just as an example of how important the role of endotoxin is in insulin resistance and diabetes. Similarly to the human study with aspirin, sterilizing the gut with antibiotics did not reduce the weight in the obese subjects (in this case mice). So, obesity may be a less...
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