fao

  1. haidut

    Fasting/exercise/lowcarb/keto may promote cancer (melanoma) metastasis

    Quite the title for this post, but I think the evidence from the study below is clear. Namely, chronic activation of the so-called "master metabolic sensor" AMPK is a key mechanism through which melanoma cells rewire their metabolism from higher into lower OXPHOS, change their physical structure...
    • haidut
    • Thread
    • ampk cancer exercise fao fasting fission lowcarb melanoma metastasis mitochondria oxphos paleo
    • Replies: 29
    • Forum: Scientific Studies
  2. haidut

    Impaired OXPHOS by high ketones drives heart failure

    Just a few weeks after my post on how excessive fatty acid oxidation (FAO) drives cancer, below is another great new study, which corroborates once again the hypothesis that excessive FAO (and/or fatty acid supply into the mitochondria of the cell) result in impaired OXPHOS and organ damage...
    • haidut
    • Thread
    • fao fatty acid oxidation heart failure ketone krebs mitochondria oxphos succinate
    • Replies: 4
    • Forum: Scientific Studies
  3. mantq

    Fatty Acid Oxidation Inhibitors

    Hey everyone, Upon doing some research on fatty acid oxidation (FAO) inhibiting drugs (like meldonium), I thought to myself, do these kind of drugs prevent us from losing fat? How would the body burn fat, if the fatty acid oxidation is inhibited? Or perhaps the drugs do not fully inhibit it? Can...
  4. A

    Inhibition of fatty acid synthesis blocks SARS-CoV-2 replication

    Caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), COVID-19 is a virus-induced inflammatory disease of the airways and lungs that leads to severe multi-organ damage and death. Here we show that cellular lipid synthesis is required for SARS-CoV-2 replication and offers an...
  5. A

    Elevated CO2 Levels Delay Skeletal Muscle Repair by Increasing Fatty Acid Oxidation

    Muscle dysfunction often occurs in patients with chronic obstructive pulmonary diseases (COPD) and affects ventilatory and non-ventilatory skeletal muscles. We have previously reported that hypercapnia (elevated CO2 levels) causes muscle atrophy through the activation of the AMPKα2-FoxO3a-MuRF1...
  6. A

    Current and future treatments of pulmonary arterial hypertension

    Therapeutic options for pulmonary arterial hypertension (PAH) have increased over the last decades. The advent of pharmacological therapies targeting the prostacyclin, endothelin, and NO pathways has significantly improved outcomes. However, for the vast majority of patients, PAH remains a...
  7. A

    Link Between Spinal Muscular Atrophy and Fatty Acid Metabolism

    Spinal muscular atrophy (SMA) is an autosomal recessive condition that results in pathological deficiency of the survival motor neuron (SMN) protein. SMA most frequently presents itself within the first few months of life and is characterized by progressive muscle weakness. As a neuromuscular...
  8. haidut

    Restoring oxidative metabolism has curative effects on cancer (leukemia)

    A great study, which directly demonstrates not only the OXPHOS deficiency characteristic of all "cancer" cells, but also proving that restoration of OXPHOS is highly therapeutic (and likely curative) for leukemia. Just as importantly, the study demonstrates that cancer cells have, in fact...
  9. haidut

    Keto (low-carb) diet causes heart fibrosis, blocks mitochondrial biogenesis

    The bad news for the low-carb / keto community keep piling on. There are a number of posts on this blog about studies demonstrating insulin resistance, diabetes, obesity and even sarcopenia as a result of low-carb diets or their close mimetic known as intermittent fasting. Now, the study below...
    • haidut
    • Thread
    • fao ffa fibrosis heart keto ketone low-carb mitochondria sirt7 sirtuin
    • Replies: 17
    • Forum: Scientific Studies
  10. haidut

    Niacinamide may treat depression by improving energetic state

    A very interesting study, sent to me by a collaborator who lives in Austria. It demonstrated that depression is accompanied by increased SIRT1 activity (i.e. increased fatty acid oxidation), lower ATP levels and redox balance shifted towards reduction. The study demonstrated that animals without...
    • haidut
    • Thread
    • atp depression fao fatty acid oxidation niainamide nicotinamide sirt1 vitamin b3
    • Replies: 11
    • Forum: Scientific Studies
  11. haidut

    Lipolysis / FFA Drive Breast Cancer By Promoting Estrogen Signalling

    The evidence for the fat-loving nature of cancer just keeps on accumulating. During the last podcast with Danny and Ray, I mentioned that in cancer cells the enzyme fatty acid synthase (FAS) is actually part of the estrogen receptor (ER) complex. As such, anything that increases the...
    • haidut
    • Thread
    • breast cancer estrogen fao fatty acid oxidation ffa lipolysis nefa randle cycle
    • Replies: 0
    • Forum: Scientific Studies
  12. haidut

    Fatty Acid Oxidation (FAO) Inhibition Abrogates Triple-negative Breast Cancer

    The evidence for the role of excessive FAO in cancer keeps piling on. As many of my readers know, triple-negative breast cancer is one of the most difficult to treat and its proportion of total breast cancer cases has been steadily rising over the last 20 years. When a patient is diagnosed with...
    • haidut
    • Thread
    • abrogate breast cancer cure fao fatty acid oxidation inhibition tnbc triple-negative
    • Replies: 2
    • Forum: Scientific Studies
  13. haidut

    Pulmonary Hypertension (usually Fatal) Driven By Increased Fat Oxidation (FAO)

    Most of the forum readers are familiar with the "mysterious" condition pulmonary arterial hypertension (PAH). I put "mysterious" in quotes, because mainstream medicine claims that its cause is unknown, its onset is unpredictable, there is no cure, and females are affected 4-5 times more often...
    • haidut
    • Thread
    • cause drive fao fatty acid oxidation ketogenesis ketosis pah pulmonary arterial hypertension
    • Replies: 1
    • Forum: Scientific Studies
  14. haidut

    Burning More Fat And Less Glucose Leads To Diabetes

    I really hope the keto community and other low-carb diet afficionados are taking note of the stream of recent studies that keep demonstrating a causative link between low-carb and/or high-fat diets, fasting, chronic stress, cortisol and diabetes. The evidence at this point is indisputable, no...
    • haidut
    • Thread
    • amino acids catabolism cause cortisol diabetes fao fat fatty acid oxidation increased insulin resistance
    • Replies: 19
    • Forum: Scientific Studies
  15. haidut

    Increased Fatty Acid Synthesis (FAS) Is Simply A Sign Of Oxygen Deficiency / Low Metabolism

    Just a quick post on a study that provides insight as to how increased fatty acid oxidation (FAO) can "paradoxically" result in increased FAS as well, thus leading to a vicious cycle most commonly seen in diabetes and cancer. One of my recent posts discussed a much more recent study that...
    • haidut
    • Thread
    • cancer diabetes electron flow fao fas fasn nad nadh oxidation oxphos oxygen randle cycle terminal electron acceptor
    • Replies: 3
    • Forum: Scientific Studies
  16. haidut

    Acidosis (Warburg Effect) Drives Cancer Through Increased Fat Oxidation (Randle Cycle)

    The evidence continues to pile on that naming the (in)famous observation made by Otto Warburg in regards to cancer an "effect" is one of the most profound falsehoods the medical profession has ever concocted. Almost a century after the Warburg "Effect" term was coined, the evidence rapidly...
    • haidut
    • Thread
    • acidosis aspirin cancer cause drive fao fas fasn lactate metabolic disease niacinamide randle cycle sirt sirt1 sirt6 warburg effect warburg-randle warburg-randle cycle
    • Replies: 8
    • Forum: Scientific Studies
  17. haidut

    Inhibiting Fatty Acid Synthesis (FAS) Dramatically Improves Sepsis Survival Rate

    Yet another study that points the finger straight at fat as a key factor in one of the most common causes of inpatient hospital mortality - sepsis. Sepsis is currently considered to be a condition of infectious (bacterial) etiology, driven by endotoxin. However, in light of the new findings it...
    • haidut
    • Thread
    • endotoxin energy fao fas fasn fatty acid oxidation fatty acid synthase infection inhibit inhibitor randle cycle sepsis tlr tlr4
    • Replies: 6
    • Forum: Scientific Studies
  18. haidut

    Niacinamide May Improve Symptoms Of ALS

    Just over a week ago I posted a thread on ALS being linked to increased fatty acid oxidation (FAO) and as such a decreased glucose availability/oxidation. ALS Tied To Increased Fat Oxidation (FAO), Increasing Glucose May Treat It Now, the study below further corroborates this FAO-disease...
    • haidut
    • Thread
    • als endotoxin fao lps microbiome niacinamide vitamin b3
    • Replies: 9
    • Forum: Scientific Studies
  19. haidut

    MS Tied To Glucose Deficiency Due To Endotoxin And Fat, Extra Glucose May Treat It

    Just a few days ago I posted the groundbreaking study on metabolic derangement in ALS - i.e. it is a diseased characterized by increased FAO, which wastes glucose. Simply increasing dietary glucose was able to greatly restrain the pathology...
    • haidut
    • Thread
    • ceramides fao fatty acid oxidation glucose insulin resistance lps mitochondria mitochondrial function ms multiple sclerosis randle cycle tlr tlr4
    • Replies: 48
    • Forum: Scientific Studies
  20. haidut

    ALS Tied To Increased Fat Oxidation (FAO), Increasing Glucose May Treat It

    I made a few posts in the past about ALS characterized by adrenal hyperactivity and suppressed gonadal function, as well as mitochondrial dysfunction and copper deficiency. Also, non-familial ALS is known to occurs 4-5 times more often in active/retired elite athletes. All of these findings...
    • haidut
    • Thread
    • als diet fao fatty acid oxidation glucose glycolysis metabolic metabolism
    • Replies: 17
    • Forum: Scientific Studies
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