estrone

Female obesity and the closely related condition PCOS are perhaps the female equivalent of the so-called "androgen hypothesis" for balding and prostate cancer in men, as the female version of this hypothesis not only blames androgens for these conditions but specifically singles out DHT as the...

As many of my readers know, the WHI studies were highly detrimental to the profits of the estrogen industry. Every since the results of those studies came out, the estrogen industry has been trying to undermine the findings and re-introduce estrogen HRT for women with the claims that estrogen is...

I posted a few studies in the past demonstrating that estrone (E1) and especially its long-lasting derivative estrone sulfate (E1S) are reliable biomarkers of both breast and prostate cancer progression/prognosis. However, for some reason the medical industry is obsessed with estradiol and since...

Finally! Some common sense is emerging from the medical profession. For one, it points the finger straight at estrogen as a possible cause of autism. And not just estradiol, which the medical profession considers the only estrogen of note, but all 3 of them (estrone, estradiol, estriol). So, all...

There is an old study often cited by Peat in regards to liver health and estrogen. That study found that vitamins B1 (thiamine) and B2 (riboflavin) are crucial for the deactivation/metabolism of estrogen by the liver. Vitamins B1 & B2 Are Required For Estrogen Inactivation By Liver The study...

About 2 years ago I posted a thread on the antagonism of pregnenolone to estrogen. Pregnenolone Is An Estrogen Antagonist That claim was from a study, which itself referenced an old French study from 1950. I asked @burtlancast to find it and he was able to trace it to a hardcopy of the French...

An unassailable dogma in endocrinology is that menopause is characterized by low estrogen levels. The fact that plasma levels are only indicative of ovarian activity is conveniently overlooked, as is the fact that fat tissue grows after menopause and fat is the primary source of estrone (estrone...

Most people on the forum have read Peat's articles on PUFA and its great synergism with the estrogenic hormones. Peat has written that saturated fats have effects opposite to those of PUFA and there are studies showing feeding saturated fat increases androgen synthesis. I have been researching...

It is well-known in medical circles (at least in doctors over 50) that some androgens like DHT are potent aromatase inhibitors (AI). In fact, before the advent of modern AI drugs like letrozole, anastrozole and fadrozole the 5-AR androgens were a mainstream therapy for estrogen-receptor-positive...

It is known that aspirin can inhibit the activation of the enzyme aromatase, which is activates by things like stress and prostaglandins. However, studies showing direct effects of aspirin on estrogenic burden / load in humans are lacking. Speaking of estrogenic burden / load, as I mentioned in...

This has been stated by Peat a few times but usually the assumption has been that pregnenolone converts into progesterone and that is how it exerts its anti-estrogenic effects. This older study claims that pregnenolone (also called delta-5-pregnenolone) is directly antagonistic to estrogen...

Ray has written several times about the changes that occur in the adrenals with aging and stress/hypothyroidism. The adrenal layers change in structure and activity in a way that favors zona glomerulosa, which results in higher production of cortisol and estrogen. This study seems to confirm...

The study also found correlation with testosterone, but the link was not consistent across the different measurement methods, while it was for estradiol and estrone. Nonetheless, it underscores Peat's recent statement that to him testosterone was almost as dangerous a hormone as estrogen...