endotoxin

  1. haidut

    Vitamin D Is Endotoxin (LPS / TLR4) Antagonist, May Treat LPS-linked Conditions

    The activation of TLR by various substances like endotoxin, ethanol / alcohol, opioids, SSRI, etc is involved in the pathogenesis of many conditions, especially IBD, colon cancer, periodontal disease, etc. There are very few effective endotoxin antagonists in clinical use, which is unfortunate...
  2. Amazoniac

    A (chronic) Very Low Dose Endotoxin Exposure Might Be As Dangerous As An Acute One

    Treehuggers, @haidut forced me to post this study with the following comments: This, unlike the majority of studies on the effects of LPS, was done using a very low dose of endotoxin; according to them, something that is compatible with the circulating levels seen in chronic metabolic...
  3. haidut

    Acute Colon / Lung Damage May Be Due To Endotoxin; Breast Milk Stops It

    The study was done to mimic the condition necrotizing enterocolitis in premature babies, but if you look at the actual study the scientists think the mechanism is probably the same for most cases of acute colon and lung damage. Once again, our old "friend" endotoxin rears its ugly head and acts...
  4. haidut

    CFS Pathology Tied To Increased Blood Levels Of Endotoxin

    After more than a decade of denial that the "mysterious" condition CFS even exists as a physiological state, mainstream medicine may be warming up to the fact that it is not simply in patients' heads. This latest study found changes in patients' microbiome as well as elevatd levels of endotoxin...
  5. haidut

    Opioids Increase Pain Through Endotoxin Receptor, Minocycline Reverses The Effect

    Most people here know Peat's opinion about opioids due to their effects on histamine, estrogen, and promoting tissue growth. A few weeks ago I posted a link in regards to the so-called "endotoxin receptor" known as TLR4, and how opioids are the main class of substances that activate that...
  6. haidut

    Prostate Enlargement (BPH) May Be Due To Endotoxin

    BPH is a very common problem, apparently affecting more than 70%of men over 50. Ray has said in some email exchanges that prostatitis and BPH are linked with endotoxin. I was not able to find much published research on the topic but this new study finally makes that claim. What is more...
  7. dd99

    Natural Taurine Reduces Endotoxin In Mice

    The study compared the effect of 'natural taurine' (from octopus viscera) with 'synthetic taurine' and saline. (I presume that the type of taurine we get in supplements isn't octopus viscera.) Natural taurine reduced endotoxin by around 25% and increased short-chain fatty acids by 30%, when...
  8. S

    No Liver Injury After Alcohol In Germ-Free Mice

    Comparing the effects of acute alcohol consumption in germ-free and conventional mice: the role of the gut microbiota Ethanol increased intestinal bacteria :cool and "high fiber diet" reduced the injury.
  9. haidut

    Vaccines Contain Endotoxin; Endotoxin May Become A Drug For Sugar Cravings

    As if using endotoxin as a drug for treating IBS is not enough of an abomination, this news release caught my eye since it states that endotoxin is now used as adjuvant in vaccines, and also that endotoxinmay become a prescribed drug for treating sugar cravings. Wow, I wonder what's next -...
  10. haidut

    Vitamin B2 Remarkably Effective Against Endotoxin, Sepsis, And Other Bacterial Infections

    Peat said in one of his interviews that vitamin B2, together with vitamin B1, selenium, vitamin K and CoQ10 are the most important substances for optimal mitochondrial function. I have been researching vitamin B2 and continue to be amazed at how underestimated this nutrient is both in...
  11. S

    Endotoxin Stimulates Serotonin Production For Hemocyte Phagocytosis

    Serotonin modulates insect hemocyte phagocytosis via two different serotonin receptors
  12. haidut

    Endotoxin Can Cause Inflammation Independently Of PUFA

    As many people on the forum know, the primary driver of inflammation in humans is the metabolism of arachidonic acid into various inflammatory mediators like prostaglandins, leukotrienes, and tromboxanes. If you remove arachidonic acid, about 90% of the inflammatory response goes away. However...
  13. haidut

    Dementia Breakthrough - Alzheimer Disease Linked To Endotoxin And Iron

    Nice to see medicine may be finally making a 180-degree turn but I would not hold my breath for it to become mainstream treatment any time soon. Given the abilities of aspirin to chelate iron directly from the brain, this may be one of the reasons for its beneficial effects on Alzheimer's...
  14. haidut

    Dengue Fever/shock May Be Simply An Endotoxin-driven Symptom

    I have been studying endotoxin and its mechanisms lately, so I will post more on that soon. For now, I will just say that endotoxin seems to mediate most of its effects through the so-called TLR4 "receptor". In agreement with Peat's writings about flu and its connection to endotoxin, this study...
  15. haidut

    Amazing Medicinal Properties Of Beta-lapachone (β-lapachone)

    This thread is similar to the one I created for emodin and in support of the Lapodin supplement I released. Lapodin: Lapodin - Dietary Supplement With Beta-lapachone And Emodin | Ray Peat Forum Emodin: Amazing Medicinal Properties Of Emodin | Ray Peat Forum The purpose of this thread is to...
  16. haidut

    Amazing Medicinal Properties Of Emodin

    This thread is similar to the one I created for beta-lapachone and in support of the Lapodin supplement I released. Lapodin: https://raypeatforum.com/community/threads/lapodin-dietary-supplement-with-beta-lapachone-and-emodin.9423/ Beta-lapachone...
  17. EndAllDisease

    Technology to Measure Endotoxin Levels

    Does anybody know of a device that can measure the levels of endotoxic-producing bacteria in the gut at any given time? If this device hasn't been invented, or you don't know of one, theoretically, what would be the most effective way to do this?
  18. Amazoniac

    Detoxifying Endotoxin

    http://www.ncbi.nlm.nih.gov/pubmed/15949133 "Animals that cannot sense endotoxin may die if they are infected by Gram-negative bacteria. Animals that sense endotoxin and respond too vigorously may also die, victims of their own inflammatory reactions." "Gram-negative bacterial endotoxin...
  19. haidut

    DHEA protects from endotoxin (even lethal doses)

    Yet another substance that can be used in cases of endotoxin overload. The study used 0, 1, 5, 25, 100 mg/kg DHEA doses in mice and lethal doses of endotoxin. The protection/survival from DHEA was dose dependent, but the biggest increase in survival was seen with the doses of 5mg/kg and 25mg/kg...
  20. haidut

    CoQ10 may prevent the negative effects of endotoxin on mitochondria

    The stud was in rats and the dosage of CoQ10 was 20mg/kg 12 hours before endotoxin administration. This means the human dosage is 2.5mg/kg-3mg/kg. The interesting thing is that AFAIK Peat has said that he does not routinely recommend CoQ10 since it increases fatty acid oxidation, and elevated...
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