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endotoxin
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Serotonin/endotoxin/PUFA As Primary Causes Of Depression And Diabetes; Can Be Easily Blocked
This is one of the unique studies that breaks away from the mainstream dogma that serotonin is the "happy hormone" and increasing it with drugs like SSRI can lead to nothing but goodness. The study not only directly states that past/current SSRI use is a risk for developing diabetes but show how...- haidut
- Thread
- 5-ht 5-ht3 5-htt diabetes endotoxemia endotoxin inflammation liver disease lps obesity pufa serotonin serotonin transporter sert tlr4
- Replies: 45
- Forum: Scientific Studies
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Low Dose Doxycycline Decreases Systemic Inflammation And Improves Glycemic Control, Lipid Profiles,
Low dose doxycycline decreases systemic inflammation and improves glycemic control, lipid profiles, and islet morphology and function in <i>db/db</i> mice Low dose doxycycline decreases systemic inflammation and improves glycemic control, lipid profiles, and islet morphology and function in...- paymanz
- Thread
- a1c adiponectin advanced glycation end products antiinflammatory apoptosis beta cells diabetes doxycycline endotoxin glycogen inflammation insulin insulin resistance insulin sensitivity lps minocycline mmp inhibitor obesity tetracycline tnf
- Replies: 5
- Forum: Articles & Scientific Studies
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Methylene Blue Is A Potent Anti-inflammatory, With Possibly The Broadest Spectrum
Some bold statements in this study, which combined both in vitro and in vivo models. The HED for methylene blue (MB) was just 0.15mg/kg, which is in the range of 10mg-15mg doses that showed great effectiveness in treating mental disorders like depression and psychosis. As you can see from the...- haidut
- Thread
- anti-inflammatory endotoxin inflammation lps methylene blue mitochondria mitochondrial respiration nitric oxide
- Replies: 17
- Forum: Scientific Studies
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Baking Soda Dramatically Increases Antibiotic Effectiveness, Could Help In Sepsis
Recently we posted some studies showing that thiamine (by itself or vitamin C) dramatically increases survival in sepsis, and lowers its severity. IV B1+Vit. C+ Cortisone Prevents Septic Induced Death Sepsis is the number one killer of hospitalized patients, so finding a way to reduce its...- haidut
- Thread
- antibacterial antibiotic baking soda bicarbonate effectiveness endotoxin infection sepsis sodium bicarbonate
- Replies: 29
- Forum: Scientific Studies
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Without Endotoxin (TLR4), An HIV Infection May Not Cause AIDS
More than 3 years ago I posted a study showing that monkeys that are natural carriers of the simian version of HIV known as SIV, do not develop AIDS. It was only after being injected with endotoxin (even when attenuated) that these monkeys develop the wasting syndrome and oppostunistic...- haidut
- Thread
- aids diet endotoxin hiv infection inflammation lps siv tlr4 wasting syndrome
- Replies: 24
- Forum: Scientific Studies
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Endotoxin, Even When Attenuated, Makes People Visibly Sick
This is a great study for two reasons. First of all, it shows that people are pretty good at judging other people's health and the study makes the recommendation that doctors should incorporate that method (judging people by appearance) into their diagnostic methods as well. Second of all, it...- haidut
- Thread
- diagnosis e. coli endotoxin judgment lps pale sick visibly
- Replies: 4
- Forum: Scientific Studies
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Endotoxin (from Low-grade Infection) As A Cause Of Crohn's, UC, And Other IBD
Not sure how many people on the forum know that Crohn's disease, which is a type of an inflammatory bowel disease (IBD), has recently been reclassified in some countries as infectious of origin and not as an autoimmune disease. The causative pathogen of Crohn's is thought to be a type of...- haidut
- Thread
- alkaline phosphatase bacteria crohn's endotoxin ibd infection recurring tlr4 uc ulcerative colitis
- Replies: 69
- Forum: Scientific Studies
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Alcohol Mostly Benign For The Liver, Causing Injury Requires Endotoxin (LPS)
Peat wrote in one of his articles that alcohol is getting a bad reputation for causing all sorts of liver disease and even liver cancer, but alcohol by itself is fairly neutral for the liver and that the role of PUFA, iron and endotoxin is being neglected by mainstream medicine. The study below...- haidut
- Thread
- alcohol endotoxin ethanol fatty liver fibrosis inflammation liver disease lps nafld
- Replies: 52
- Forum: Scientific Studies
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SSRI Drugs (Prozac) Worsen Prenatal Stress And May Contribute To Autism
I am posting this study because it may explain why the incidence of autism is much higher in male than in female offspring. As I posted in a few other threads before, serotonin is one of the likely direct causes of the autism pathology and it is of course elevated during chronic stress...- haidut
- Thread
- autism endotoxin exacerbate fluoxetine lps prenatal prozac serotonin ssri stress tlr4 worsen
- Replies: 3
- Forum: Scientific Studies
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The Brain Damage In Cases Of TBI May Be Partially Driven By Gut Bacteria
Traumatic brain injury (TBI) is one of the most common injuries sustained by soldiers on the battleield, as well as by various athletes (NFL, NHL, major league soccer, etc). Repeated TBI events or even a single TBI of sufficient severity can trigger what is commonly known as chronic traumatic...- haidut
- Thread
- cte endotoxin exacerbate gut flora gut permeability infection inflammation microbiome tbi tlr4
- Replies: 1
- Forum: Scientific Studies
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Endotoxin (LPS) Theory Of Atherosclerosis (CVD)
I posted a study more than year ago, which examined the role of NO in aging and disease. The Nitric Oxide (NO) Theory Of Aging One of the main endogenous stimulators of NO synthesis is endotoxin (LPS). It turns out that the connection between LPS and CVD has been studied for a long time in...- haidut
- Thread
- atherosclerosis causative cvd diabetes endotoxin inflammation insulin resistance lps obesity stress stroke tlr4
- Replies: 24
- Forum: Scientific Studies
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Plain (unmodified) Adamantane Is A Powerful Inhibitor Of NO Synthesis
Many people on the forum are familiar with the beneficial properties of adamantane and its derivatives. However, most of the research conducted on the beneficial effects of these chemicals has been with adamantane derivatives such as amantadine, memantine, rimantadine, bromantane, etc. When we...- haidut
- Thread
- adamantane endotoxin inhibitor inos lps nitric oxide no synthesis
- Replies: 11
- Forum: Scientific Studies
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Bacterial Lipids (endotoxin), Not Cholesterol, May Be A Cause Of CVD
The role of endotoxin (and TLR) in cardiovascular disease (CVD) is probably well-known by most people on this forum. Peat rarely writes on a topic without mentioning either endotoxin or keeping the gut clean as one of the main paths to good health. The role of cholesterol is finally getting to...- haidut
- Thread
- bacteria endotoxin gum gut lipids mouth periodontal tlr2
- Replies: 22
- Forum: Scientific Studies
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Alcohol "addiction" Driven By Endotoxin (TLR4)
I posted a few threads in the past about addiction, and especially alcohol addiction being driven by high cortisol and low dopamine. This new study adds more pieces to the puzzle by implicating endotoxin in that process as well. Just as importantly, the study found that the desire to drink...- haidut
- Thread
- alcohol alcoholism curb cure drinking endotoxin naltrexone tlr4 treat
- Replies: 46
- Forum: Scientific Studies
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Higher Fat Diets And Fat Emulsification Increase Endotoxin (in Obese Males)
High dietary fat is one of the primary factors for increased endotoxin load, especially if the fat is PUFA. This is probably one of the main reasons Peat prefers lower fat diets. However, most of the studies on the fat-endotoxin link so far have been on animal models. This new human study...- haidut
- Thread
- absorption chronic diet disease emulsification endotoxin high-fat increase obesity
- Replies: 12
- Forum: Scientific Studies
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Magnesium Sulphate Prevents LPS (endotoxin) Induced Cell Death
Magnesium sulphate prevents lipopolysaccharide-induced cell death in an in vitro model of the human placenta. - PubMed - NCBI Pregnancy Hypertens. 2016 Oct;6(4):356-360. doi: 10.1016/j.preghy.2016.08.237. Epub 2016 Aug 30. Magnesium sulphate prevents lipopolysaccharide-induced cell death in an...- raypeatclips
- Thread
- endotoxin lps magnesium
- Replies: 0
- Forum: Scientific Studies
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DeFibron - Liquid Methylated SFA For Lab/R&D
Ever since I read in one of Ray's articles about the ability of saturated fat to reverse even advanced liver fibrosis (cirrhosis) I have been researching the effects of various saturated fatty acids on a number of organs and tissues. A number of studies have been posted on the forum indicating... -
Candida Overgrowth Is A Major Factor In (alcoholic) Liver Damage / Cirrhosis
Over the last 5 years or so it has become very fashionable among many "naturopaths" to throw the diagnosis "Candida overgrowth" at every symptom of gut dysfunction people present with at the doctor. Peat has spoken about Candida overgrowth and how the fungus typically only becomes an issue in...- haidut
- Thread
- alcohol candida cirrhosis endotoxin glucans inflammation intestinal permeability liver disease lps tlr4
- Replies: 42
- Forum: Scientific Studies
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Endotoxin (LPS) Is The Cause Of Venous Malformations In The Brain (CNS)
As a former athlete I am keenly aware of the several conditions that are known to have much higher incidence in (even very young) athletes. Aside from cardiac arrest and kidney damage, other conditions with higher incidence in athletes include aneurysms and various other vascular disorders in...- haidut
- Thread
- aneurysm antibiotic brain ccm cerebral cavernous malformation endotoxin lps microbiome tlr4
- Replies: 10
- Forum: Scientific Studies
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Supplementary Choline Raises Risk Of Blood Clots; Aspirin To The Rescue
Ray has written about the dangers of choline and its close relationship with estrogen. The histamine and acetylcholine receptors are perhaps the two main systems through which estrogen negatively affects the systemic health of the organism. As such, antihistamine and antocholinergic drugs can...- haidut
- Thread
- blood clotting carnitine choline cvd diet endotoxin gut flora microbiome platelet aggregation risk tmao
- Replies: 60
- Forum: Scientific Studies