1. Mauritio

    Pregnenolone for the treatment of L-DOPA-induced dyskinesia in Parkinson's disease

    In this study they showed that administering pregnenolone to rats with parkinsons ameliorated the dyskinesia, caused by L-DOPA. The Human equivalent dosages were 75mg, 225mg and 450mg per day. There was a dose-response effect, meaning higher dose = more effective. Now they often get the MoA...
  2. S

    Dysregulated Dopamine Release From Serotonin Terminals Is The Prime Trigger Of Dyskinesia In The Rat

    Dopamine released from 5-HT terminals is the cause of l-DOPA-induced dyskinesia in parkinsonian rats
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