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  1. L

    Deprenyl – Peatarian-Safe?

    Has anyone asked Ray Peat his opinion about this drug? Would he think it is safe for long term usage? Do you think it is safe, and good to use as a nootropic?
  2. haidut

    Lanosterol - Liquid Lanosterol For Lab/R&D

    I guess most people on the forum who have heard of lanosterol know it in the context of treating cataracts. Lanosterol - Wikipedia There is a company out there who used to sell lanosterol as eye drops and it is insanely expensive - $100 for a meager 10mg lanosterol. Anyways, lanosterol is...
  3. haidut

    Ritanserin - Serotonin Antagonist For R&D Use Only

    As promised, I finally got around to releasing the unicorn of the anti-serotonin world - i.e. the chemical known as ritanserin. It does not have a trade name as it is a research/lab chemical only and was never submitted for approval by the FDA. However, research with ritanserin is thriving and...
  4. haidut

    Vitamin D Is Dopaminergic And Decreases Obesity And Addiction Behaviors

    Over the last few years, I have posted studies on the forum showing that the vitamin E, A, and K all have dopaminergic activity that contributes to their positive effects on metabolism and health. This study discovered that vitamin D is another potent dopamine agonist, and that its dopaminergic...
  5. P

    Reversal Of Dopamine System Dysfunction In Response To High-fat Diet

    Reversal of dopamine system dysfunction in response to high-fat diet. - PubMed - NCBI Abstract OBJECTIVE: To test whether high-fat diet (HFD) decreases dopaminergic tone in reward regions of the brain and evaluate whether these changes reverse after removal of the HFD. DESIGN AND METHODS...
  6. P

    Activation Of The Dopamine 1 And Dopamine 5 Receptors Increase Skeletal Muscle Mass And Force Produc

    Activation of the dopamine 1 and dopamine 5 receptors increase skeletal muscle mass and force production under non-atrophying and atrophying condit... - PubMed - NCBI Abstract BACKGROUND: Control of skeletal muscle mass and force production is a complex physiological process involving...
  7. P

    Antidepressant-like Effect Of Creatine In Mice Involves Dopaminergic Activation

    Antidepressant-like effect of creatine in mice involves dopaminergic activation. - PubMed - NCBI Abstract Creatine has been shown to play a significant role in health and disease. However, studies concerning its effect on mood are scarce. This study investigated the effect of creatine (p.o.)...
  8. P

    The Effect Of A Low Dose Of Piracetam On The Activity Of The Dopaminergic System In The Rat Striatum

    [The effect of a low dose of piracetam on the activity of the dopaminergic system in the rat striatum]. - PubMed - NCBI Abstract The low-dose effect (100 mg/kg, intraperitoneally) of the nootropic drug pyracetam on some DA-ergic neurochemical parameters of the rat striatum, as well as on the...
  9. P

    Putting Desire On A Budget: Dopamine And Energy Expenditure, Reconciling Reward And Resources

    Putting desire on a budget: dopamine and energy expenditure, reconciling reward and resources. - PubMed - NCBI Abstract Accumulating evidence indicates integration of dopamine function with metabolic signals, highlighting a potential role for dopamine in energy balance, frequently construed...
  10. P

    Dopaminergic Mechanism Of Antidepressant Action In Depressed Patients

    Dopaminergic mechanism of antidepressant action in depressed patients. - PubMed - NCBI Abstract Clinical studies have not yet determined a common mechanism of action for antidepressant drugs, which have primary sites of action on a variety of different neurotransmitter systems. However, a...
  11. P

    Some Pentoxifylline Studies

    Pentoxifylline Reverses Oxidative Mitochondrial Defect in Claudicating Skeletal Muscle The effect of pentoxifylline on filterability of normal red blood cells and their adhesiveness to cultured endothelial cells - Springer Pentoxifylline Neuroprotective Effects Are Possibly Related to Its...
  12. P

    Dopamine D2-like Receptor Agonists Accelerate Barrier Repair And Inhibit The Epidermal Hyperplasia I

    Dopamine D2-like receptor agonists accelerate barrier repair and inhibit the epidermal hyperplasia induced by barrier disruption. - PubMed - NCBI Abstract Two families of G protein-coupled receptors of the neurotransmitter dopamine, i.e., dopamine 1-like family (D1-like receptor) and dopamine...
  13. haidut

    Prolactin As A Causative Agent In Prostate Cancer

    Just wanted to post this, given the almost perfect correlation between prolactin and expression of estrogen "receptors" in tissues. If prolactin is a causative agent in prostate cancer, than the current idea of treating prostate cancer with estrogen is laughable. I also posted a study showing...
  14. haidut

    Aspirin Is Dopaminergic; Additive Effects With Caffeine

    It is a well established fact that caffeine is dopaminergic in effect even though it does not bind directly to any dopamine "receptors". It looks like aspirin is also dopaminergic. As you can see from the study, using aspirin alone required doses equivalent do 5g - 6g in a human. However, in a...
  15. haidut

    Vitamin A is dopaminergic and reduces prolactin in humans

    In theory, anything that reduces prolactin will likely also reduce estrogen and vice versa. So, since vitamin A is anti-estrogenic I wondered if there is evidence that vitamin A will lower prolactin and/or increase dopamine. Below is some evidence that vitamin A is indeed dopaminergic and lowers...