1. haidut

    Stress/Injury (mitochondrial dysfunction) sufficient to cause de-differentiation, even cancer

    One of the most pernicious myths in medicine is the "irreversibility" of several cellular processes related to aging, diabetes, fibrosis and, of course, cancer. Perhaps the most fundamental of those processes is cellular differentiation. To this day, the dominant opinion in medicine is that once...
  2. haidut

    Neuron/brain growth depends on metabolism (OXPHOS)

    As many of my readers know, the mainstream medical dogma is that the number of neurons in the human grain increases until early adulthood, after which it stops completely. Thus, medicine views the adult human brain as having a fixed number of neurons and any damage to them or complete loss of...
  3. haidut

    Stem cells availability, and their differentiation, depend on metabolism

    Once again, the master controller role metabolism plays in human life is revealed in yet another experiment. The study below demonstrated that the degree of cell "stemness", as well as its differentiation into a specific organ/tissue depends entirely on the metabolic rate of the cell, and thus...
  4. haidut

    Loss of mitochondrial function (OXPHOS) induces de-differentiation (cancer)

    The study only focuses on the lymphatic system and its cells, but the principle is general and has been observed in other organ/tissue cells. The most obvious example is cancer - no matter which organ it occurs in, the tumor is composed of de-differentiated cells not unlike the stem cells from...
  5. haidut

    Vitamin D can force cancer cells to differentiate back into normal

    Danny and I already discussed this topic on a recent podcast, but I decided to post the studies anyways, considering how important the topic is. While progesterone and testosterone are the most well-known differentiating factors in humans, the role of vitamin D has gone largely unnoticed. The...
  6. haidut

    Inosine Powerfully Stimulates Mitochondriogenesis, Oxidative Metabolism & Cell Differentiation

    Yet another absolutely great study on inosine. It shows that not only can inosine replenish ATP (as shown in the previous studies I posted) but it can inhibit excessive glycolysis, lower lactate, and dramatically improve oxidative metabolism - effects which are key driver of cell differentiation...
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