diabetes

  1. Giraffe

    Repair Of Pancreatic Beta-Cells

    Repair of Pancreatic β-Cells: A Relevant Phenomenon in EarlyIDDM Most studies dealing with the pathogenesis of IDDM have emphasized the immune assault against β-cells. In this perspective, we review the data that suggest that the β-cell destruction of IDDM depends on a balance between β-cell...
  2. haidut

    Changes In Thiamine Levels May Be The First Sign Of Type I Diabetes

    The study is focusing on the fashionable topic of "microbiome analysis", which is most likely a fad that won't lead to any breakthrough cures. However, the important finding of the study is that changes of vitamin B1 (thiamine) levels are involved in the pathogenesis of diabetes. Sudden drop in...
  3. haidut

    DHT Lowers Risk Of Diabetes In Older Males

    Most endocrinologists view DHT as an almost exclusively bad hormone. Aside from the its much publicized (and likely incorrect) role in prostate cancer and MPB, endocrinologists consider DHT as a causative agent in insulin resistance and even diabetes type II. Most of that misguided opinion...
  4. S

    Endotoxin, Obesity And Diabetes (Podcast)

    Greetings, this is the first in a series of podcasts looking at our old friend endotoxin. I have a look at some rodent studies relating to diabetes, obesity, "metabolic syndrome" and NAFLD/NASH. Biocast Episode 009 – Endotoxin, Obesity and Diabetes | Resonant FM
  5. haidut

    Androsterone - A Potential Treatment For Insulin Resistance And Diabetes

    In another recent thread, I posted about androsterone's potent thyromimetic effects. Given the ability of thyroid hormone to improve insulin sensitivity and even reverse diabetes type II, it would not be surprising that androsterone would also exhibit such effects. And indeed, androsterone...
  6. haidut

    Fluoride In Tap Water Could Be A Causative Factor In Diabetes

    While the public health authorities continue their mantra on the "benefits" of fluoride for teeth and bone health, there are quite a few research groups that have been producing solid evidence to the contrary. As many of you know, fluoride is a proven thyroid inhibitor. As such, it is expected...
  7. P

    Biotin Decreases Serum Free Fatty Acids

    Effects of Biotin Supplementation in the Diet on Adipose Tissue cGMP Concentrations, AMPK Activation, Lipolysis, and Serum-Free Fatty Acid Levels. - PubMed - NCBI Several studies have shown that pharmacological concentrations of biotin decrease hyperlipidemia. The molecular mechanisms by which...
  8. P

    Biotin Suppresses Food Intake

    Biotin augments acetyl CoA carboxylase 2 gene expression in the hypothalamus, leading to the suppression of food intake in mice. - PubMed - NCBI It is known that biotin prevents the development of diabetes by increasing the functions of pancreatic beta-cells and improving insulin sensitivity...
  9. L

    Diabetes - A Brain Disease?

    A single injection can eliminate type 2 diabetes in mice for months A single injection can eliminate type 2 diabetes in mice for months
  10. P

    Effects Of Excess Dietary Iron And Fat On Glucose And Lipid Metabolism

    Effects of excess dietary iron and fat on glucose and lipid metabolism. - PubMed - NCBI Abstract PURPOSE: Diets rich in fat and energy are associated with metabolic syndrome (MS). Increased body iron stores have been recognized as a feature of MS. High-fat diets (HFs), excess iron loading and...
  11. haidut

    Emotional Stress Linked To Diabetes

    Considering the direct connection between stress, cortisol, and insulin resistance, I think the link should not be surprising but apparently it is to the fellows in white coats. http://www.psyneuen-journal.com/article/S0306-4530%2816%2930134-2/abstract Stress-diabetes link detailed in new study...
  12. P

    Introducing The New Wonder Cure. SUGAR!

    Introducing the new wonder cure... SUGAR! Derek Ripley, 66, from Ellesmere Port, Cheshire, has diabetes For 10 years, his lower legs were constantly covered in agonising ulcers But when he started pouring sugar on them, they disappeared in a month
  13. Dan W

    Caffeine Improving Sugar Handling And Fat Accumulation In Rats

    I finally managed to post a study before Haidut's high-powered laser-guided tracking system could beat me to it. Caffeine Restores Insulin Sensitivity and Glucose tolerance in High-sucrose Diet Rats: Effects on Adipose Tissue The concentrations necessary might not be as high as they sound...
  14. haidut

    SSRI Drugs Increase Stroke Mortality In People With Diabetes

    The study was done on people with diabetes and the presumption was that it was the diabetes that gave them the stroke, not the SSRI. I, personally, dispute that assumption and think that the SSRI was responsible for both the increased stroke incidence and increased mortality from that stroke, as...
  15. B

    Higher Plasma Dairy Fat Associated With Lower Incidence Of Diabetes

    Circulating Biomarkers of Dairy Fat and Risk of Incident Diabetes Mellitus Among US Men and Women in Two Large Prospective Cohorts
  16. haidut

    Bromocriptine Prevents CVD Events Associated With Type II Diabetes

    Your doctor probably does not know that bromocriptine is approved for the treatment of type II diabetes. Even if she/he did know about it, the cited mechanism of action is "unkown" or a "mystery". But at least, it is a step in the right direction - i.e. away from serotonin, estrogen and...
  17. P

    Some Pentoxifylline Studies

    Pentoxifylline Reverses Oxidative Mitochondrial Defect in Claudicating Skeletal Muscle The effect of pentoxifylline on filterability of normal red blood cells and their adhesiveness to cultured endothelial cells - Springer Pentoxifylline Neuroprotective Effects Are Possibly Related to Its...
  18. haidut

    The Anti-cortisol Effects Of Niacinamide

    This is yet another confirmation of my suspicion that sedative substances lower cortisol levels. Niacinamide is officially recognized as a GABA-A agonist, but apparently this is not the major reason behind its effect on cortisol. The enzyme that de-activates cortisol - 11b-HSD2 - is apparently...
  19. Tarmander

    Victoza And Glp-1

    This may be a long shot. I have a friend who recently started taking Victoza which is used to treat type 2 diabetes. I have been looking for studies and information on GLP-1 without much luck. From some of the reviews I have read from people, it seems to be positively received, but I believe...
  20. ecstatichamster

    Can Glucagon Be The "baddie" Rather Than Cortisol In Type 2 Diabetes?

    A lot of what Ray talks about is how to prevent chronically elevated stress hormones, the "stress metabolism". But at least as far as diabetes is concerned, perhaps glucagon is the criminal here? In this study, they induce diabetes through a routine destruction of beta cells often done in...
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