dht

  1. haidut

    Raising Serum Androgens Using DHEA, Pregnenolone, And Vitamin K

    User testimony (4/26/2021): My Experiences With Raising Androgens Log (Pansterone, k2, magnoil) Many people use supplements like DHEA, pregnenolone, and progesterone with the goal of raising their androgens and lowering estrogen. While this approach works for raising tissue levels of steroids...
    • haidut
    • Thread
    • androgens androstenedione aromatase dhea dht gonads hypogonadism menaquinone pregnenolone serum steroidogenesis synthesis testosterone vitamin k vitamin k2
    • Replies: 444
    • Forum: Scientific Studies
  2. haidut

    Demyelinating Conditions Like MS Can Be Treated By Androgens

    Ray wrote quite a bit on the topic of estrogen as a causative factor in demyelination and progesterone / pregnenolone as remyelinating agents. I posted an animal study recently on using DHT to completely reverse the pathology of the MS that model...
    • haidut
    • Thread
    • androgen receptor androgens dht multiple sclerosis physiological remyelination reversal study testosterone treatment
    • Replies: 6
    • Forum: Scientific Studies
  3. haidut

    DIM Is A Potent Androgen Antagonist And Estrogen Agonist

    The question of supplementing DIM often comes up on this forum despite Peat directly advising against it. Aside from its known anti-thyroid functions, we can now add a potent androgen antagonism to its list of "benefits". So, please stop loading up on DIM in the (false) hope that it somehow...
    • haidut
    • Thread
    • androgen antagonist dht dim estrogen agonist prostate receptor study
    • Replies: 38
    • Forum: Scientific Studies
  4. haidut

    DHT Lowers Risk Of Diabetes In Older Males

    Most endocrinologists view DHT as an almost exclusively bad hormone. Aside from the its much publicized (and likely incorrect) role in prostate cancer and MPB, endocrinologists consider DHT as a causative agent in insulin resistance and even diabetes type II. Most of that misguided opinion...
    • haidut
    • Thread
    • dht diabetes insulin resistance insulin sensitivity males men older shbg study type 2
    • Replies: 9
    • Forum: Scientific Studies
  5. haidut

    Androsterone - The Legal Pro-hormone For Potent 5-AR Derived Androgens

    Adnrosterone is a downstream metabolite of DHT and just like DHT it is a 5-AR derived steroid. What is even more interesting is that androsterone is not just a metabolite of DHT but can be converted back to DHT as needed in target tissues where DHT is needed. In fact, androsterone has at least 2...
    • haidut
    • Thread
    • 5-alpha reductase androgens androsterone dht prohormone
    • Replies: 10
    • Forum: Scientific Studies
  6. haidut

    Androsterone - A Potent Steroidal Aromatase Inhibitor

    It is well-known in medical circles (at least in doctors over 50) that some androgens like DHT are potent aromatase inhibitors (AI). In fact, before the advent of modern AI drugs like letrozole, anastrozole and fadrozole the 5-AR androgens were a mainstream therapy for estrogen-receptor-positive...
    • haidut
    • Thread
    • 5-alpha reductase androsterone aromatase aromatase inhibition cortisol dht estrogen estrone
    • Replies: 36
    • Forum: Scientific Studies
  7. haidut

    DHT Is The Primary Driver Of Male Sexual Activity And Is Crucial For Male Orgasm

    Yet another study pointing out that DHT is quite the good guy, for both men and women alike. Contribution of dihydrotestosterone to male sexual behaviour. - PubMed - NCBI "...RESULTS: Serum dihydrotestosterone concentration was the only independent hormonal predictor of the frequency of...
  8. haidut

    Androgens (DHT, T) Treat Prostate Cancer, Especially When Combined With Vitamin D

    I recently posted a study showing that vitamin D inhibits the deactivation of androgens, which results in a build up of strong androgens like DHT. https://raypeatforum.com/community/threads/vitamin-d-inhibits-the-deactivation-of-androgens.12411/ That study conclude that this effect of vitamin D...
    • haidut
    • Thread
    • androgen receptor androgens calcitriol cholecalciferol dht prostate cancer testosterone therapeutic vitamin d
    • Replies: 29
    • Forum: Scientific Studies
  9. haidut

    Vitamin D Inhibits The Deactivation Of Androgens

    Vitamin D is one of the most versatile substances in Peat world. It is actually a steroid and not a true vitamin, and as a steroid it is expected to have effects on other steroids. Its role in opposing estrogen, together with the other fat-soluble vitamins, is well-known. Now, this study shows...
    • haidut
    • Thread
    • androgen receptor androgens androsterone calcitriol deactivation dht glucuronidation inhibitor study vitamin d
    • Replies: 12
    • Forum: Scientific Studies
  10. haidut

    Androgen Treatment Highly Effective For Breast Cancer

    The first study (animal) looked at various approaches and found that removal of the pituitary caused the complete disappearance of breast cancer in ALL of the studied animals. The administration of DHT caused almost complete regression in 82% (14 out of 17) of the animals. The HED for DHT was...
    • haidut
    • Thread
    • anastrozole androgens aromatase inhibition breast cancer dhea dht hypophysectomy testosterone
    • Replies: 8
    • Forum: Scientific Studies
  11. D

    Who Has Used Or Is Using DHT?

    DHT seems to be the progesterone for males, with its protective effects. It is anti-serotonin, anti-cortisol, and anti-estrogen, I even saw a study which said it can promote progesterone. A few people have posted about their experience with DHT scattered in different threads. I make this thread...
  12. Drareg

    Riboflavin, A Testosterone 5 Alpha-reductase Inhibitor

    Can anyone access the full study? Sounds Interesting.I didn't have a great experience of Riboflavin when I took it a while back. Riboflavin, a testosterone 5 alpha-reductase inhibitor. - PubMed - NCBI
    • Drareg
    • Thread
    • 5 alpha-reductase inhibitor dht riboflavin study testosterone
    • Replies: 54
    • Forum: Scientific Studies
  13. haidut

    DHT Lowers Serotonin Synthesis, May Treat (testicular) Cancer

    This is a great study for a number of reasons. 1. First, it suggests that DHT is not the evil substances for male reproductive organs. This includes prostate cancer, for which DHT to this day is cite as the main culprit. 2. Second, the study establishes the key role serotonin plays in the...
  14. haidut

    DHT Stimulates Its Own Synthesis

    The stress hormone estrogen is well-known for its ability to stimulate its own synthesis, resulting in a vicious circle. Some of the beneficial steroids like pregnenolone do the same, but for pretty much all others like T, cortisol, aldosterone, and even progesterone there is a feedback...
    • haidut
    • Thread
    • 5-alpha reductase dht feed-forward positive feedback loop stimulate
    • Replies: 11
    • Forum: Scientific Studies
  15. haidut

    DHT Is Estrogen "receptor" Antagonist

    I have posted studies on DHT inhibiting aromatase and increaseing estrogen conjugation and excretion by the liver. However, this study shows that DHT is actually capable of direct anti-estrogen activity by binding to and antagonizing the estrogen "receptor" similarly to progesterone and vitamin...
  16. haidut

    DHT Reduces Glucocorticoid Effects

    I mentioned this on one of the Danny Roddy shows, but wanted to post this study here as many people have been asking me for references over email. In addition to reducing glucocorticoid effects, DHT is also an estrogen "receptor" antagonist as I posted in another thread. DHT Is Estrogen...
  17. haidut

    Niacinamide Is Androgenic And Increases Dht Effects/signaling

    I just posted a study showing that inhibition of SIRT1 is anti-estrogenic, and SIRT1 inhibitors like niacinamide have similar effects to the estrogen receptor antagonist fulvestrant. Niacinamide Is Anti-estrogenic | Ray Peat Forum This study shows that, again through inhibition of SIRT1...
    • haidut
    • Thread
    • androgenic androgens dht hdac inhibitor niacinamide receptor sirt1 sirtuins study
    • Replies: 48
    • Forum: Scientific Studies
  18. Zachs

    Coconut Oil Reduced DHT By Inhibiting 5-ar?

    This was something I researched a bit a few years ago when first learning about Ray Peat and his affinity for coconut oil. I actually asked him this question but he seemed to not know the answer. Lauric acid among other fatty acids is known for blocking the conversion of DHT by inhibiting...
    • Zachs
    • Thread
    • 5-alpha reductase coconut oil dht inhibitor reduction study
    • Replies: 11
    • Forum: Scientific Studies
  19. johnwester130

    Saw Palmetto harms the prostate and does not block DHT

    Has peat ever written specifically about DHT ? It seems to be very beneficial and youth promoting but I have no sources to prove this. Saw Palmetto Called Ineffective . . . By SIRI E. NILSSON Feb. 8, 2006 Saw palmetto, an over-the-counter herbal therapy used by more than 2 million men to...
  20. N

    Primoboblan - A Novel DHT Derivative

    Primobolan is a DHT derived anabolic steroid Highly anabolic, yet it's androgenic qualities are very limited Increases muscle by catalysing muscle cell production Has a specific mechanism which accelerates fat loss Will improve mood and immunity Lowers cortisol Will protect tissues from...
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