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Dear Carnivore Dieters, A Muscle Meat Only Diet is Extremely Healing Because it is a Low "vitamin A" Diet. This is Why it Works so Well...
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dhea
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DHEA As A Cure For Cancer
A fascinating study, which highlights once again not only the role of one of the "youth" steroids in human health but also demonstrates that the protective/therapeutic mechanisms of DHEA against cancer are due to increase in metabolism and ROS generation. The primary restrictive mechanism on ROS...- haidut
- Thread
- cancer cure dhea dhea-s g6pd g6pdh ros suppression treatment tumor
- Replies: 63
- Forum: Scientific Studies
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DHEA Can Reset The Circadian Clock, Treat Jetlag
Disruptions in the circadian clock have been shown to directly cause a number of disease including obesity, diabetes, cancer and neurodegenerative diseases like Alzheimer, Parkinson, and even ALS. People working night shifts or engaging in frequent flying across many timezones are the most...- haidut
- Thread
- circadian clock circadian rhythm dhea jetlag reset restore shorten
- Replies: 6
- Forum: Scientific Studies
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CortiNon - Liquid Progesterone/DHEA Mix
This product does not really need any introduction to anybody familiar with Peat's work. I have wanted to release it for a long time but over the last few months the studies I found related to the anabolic and anticatabolic effects of progesterone, combined with the fact that Peat has told quite... -
Cortisol And Aldosterone Cause Vascular Calcification
In one of his newsletter circa 2015, Ray wrote about the role of aldosterone in heart failure, heart attacks, shock, and edema. He conjectured that aldosterone antagonists would one day be recognized as therapeutic for these conditions. Almost all types of heart disease start with vascular...- haidut
- Thread
- aldosterone cortisol cvd dhea emodin heart disease mineralocorticoid pregnenolone progesterone receptor salt sodium vascular calcification
- Replies: 39
- Forum: Scientific Studies
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Exercise + Fasting Is Stress, Causes Obesity And IR, And Requires Cortisol Blockade To Reverse
I think this thread will ring true for all people who at some in their lives exercised in order to lose weight. Just like fasting, it works great in younger age (<30) but it really masks a bigger metabolic problem and of course badly backfired in the long run. Exercise is a forced/stressed...- haidut
- Thread
- antagonist caloric restriction corticol dhea exercise fasting glucocorticoid insulin resistance mifepristone obesity progesterone receptor ru486 stress
- Replies: 148
- Forum: Scientific Studies
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Structural Requirements For An Optimal Anti-Catabolic Steroid
This post will be a bit long, but I hope it is worth it. I think @Jsaute21 and @dand will find it highly interesting but the information here applies just as much to females wishing to preserve lean tissue and prevent the catabolism that often occurs with aging. Here we go. Lately, I have been...- haidut
- Thread
- anabolic androgenic androsterone anticatabolic dhea dht glucocorticoid progesterone receptor ru486 steroid testosterone
- Replies: 226
- Forum: Scientific Studies
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Even A Slight Increase In Estrogen Strongly Decreases DHEA Levels
I posted a few studies in the past revealing that in old age (and menopause) the levels of pregnenolone, progesterone and DHEA declines, while that of cortisol and aldosterone stays the same or even increases. Pregnenolone, Progesterone And DHEA Drop, Cortisol Rises In Aging The decline in...- haidut
- Thread
- aging decline dhea dhea-s disease estradiol estrogen frailty menopause
- Replies: 19
- Forum: Scientific Studies
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Alzheimer Disease (AD) May Be Simply Diabetes Of The Brain
I touched upon this topic in one of the Danny Roddy shows we did last year but the evidence since then has continues to accumulate that AD is entirely a metabolic disorders, basically identical to diabetes but focusing on the brain. A recent study found that delirium, an acute form of...- haidut
- Thread
- ad alzheimer's brain dementia dhea diabetes glucose inhibitor insulin resistance memantine potassium channel
- Replies: 13
- Forum: Scientific Studies
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Finasteride Causes Physical Damage To Nerves, Depression, ED, Steroid Imbalance
After a decade of denying that a thing such as PFS exists, mainstream medicine seems to be wisening up to the fact that this poison does a lot more than lower the "bad" DHT. Up until very recently, it was common to simply measure blood steroid levels and then declare that they had rebounded upon...- haidut
- Thread
- 5a-dhp allopregnanolone damage depression dhea dht edd erectile dysfunction finasteride imbalance mdd nerve nervous system pregnenolone progesterone pudental steroid
- Replies: 41
- Forum: Scientific Studies
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Low DHEA-S Predicts Fractures In Older Men
There is a big push to start treating older men with estrogen, just as women are, because estrogen is "good for the bone". No evidence exists to support this approach and in fact multiple studies in women have shown that low DHEA, and not estrogen, is what is associated with weak bones. In...- haidut
- Thread
- androgen bone deficiency dhea dhea-s fractures men older
- Replies: 3
- Forum: Scientific Studies
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Palmitic Acid Is Androgen Agonist, Increases Androgen Synthesis, Decreases Cortisol
Palmitic acid has a bad reputation in mainstream medicine and the blogosphere. It is claimed to directly cause insulin resistance, obesity and even hypogonadism. Well, these studies found the exact opposite. The first one found that methyl-palmitate (MP) is an actual androgen receptor agonist...- haidut
- Thread
- androgen agonist androgen receptor androgenic dhea increase palmitate palmitic acid saturated fat synthesis
- Replies: 27
- Forum: Scientific Studies
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Effects Of Morphine Dependence And Withdrawal On Levels Of Neurosteroids In Rat Brain
Effects of morphine dependence and withdrawal on levels of neurosteroids in rat brain. - PubMed - NCBI It's a rat study but I think the results are applicable to humans. "The chronic morphine administration (ip) resulted in a marked decrease in the brain concentrations of pregnenolone (PREG)...- BigYellowLemon
- Thread
- allopregnanolone dhea dhea-s morphine naloxone naltrexone neurosteroid opioids pregnenolone progesterone steroids
- Replies: 5
- Forum: Scientific Studies
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DHEA And Frontal Fibrosing Alopecia: Molecular And Physiopathological Mechanisms
ABSTRACT The transforming growth factor-beta 1 (TGFβ1) promotes fibrosis, differentiating epithelial cells and quiescent fibroblasts into myofibroblasts and increasing expression of extracellular matrix. Recent investigations have shown that PPAR (peroxisome proliferator-activated receptor*) is...- Entropy
- Thread
- alopecia dhea
- Replies: 4
- Forum: Scientific Studies
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Pregnenolone, Progesterone And DHEA Drop, Cortisol Rises In Aging
I posted a few times about the steroidal characteristics of aging. Many people think there is a drop in testosterone (T) in aging and that is what drives the frailty of aging both in men and women. However, numerous studies show that that total T does not decrease with aging. What does seem to...- haidut
- Thread
- adrenals aging cortisol dhea dht estradiol gonads pregnenolone progesterone steroidogenesis steroids testosterone
- Replies: 29
- Forum: Scientific Studies
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Pregnenolone (and DHEA) May Protect From Heart Disease
In some of his recent emails to people Ray recommended pregnenolone as a substance that lowers prostaglandins and inflammation. This mechanism of action also happens to be the officially proposed one for the benefits in heart disease seen with aspirin use. I was looking for the studies to...- haidut
- Thread
- cvd dhea dhea-s heart disease pregnenolone pregnenolone sulfate protective trpm3
- Replies: 0
- Forum: Scientific Studies
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Acne At An Age Older Than 25 May Be A Sign Of Systemic Disease
The topic of acne has come up many times on this forum and appears to be anything but solved. While the pubertal and late teen acne is relatively well understood and often responds quite well to antibiotics or hormonal therapy, acne at an older age is much less understood. The predominant view...- haidut
- Thread
- acne cortisol dhea dhea-s hyperandrogenism pcos prolactin sign systemic systemic disease testosterone
- Replies: 33
- Forum: Scientific Studies
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Even Minor Stress Substantially Decreases DHEA-S Levels
Most endocrinologists are at a loss when asked what leads to lower DHEA-S levels. The generic response is "aging" but the DHEA-S have been steadily declining over the last 30 years (just as testosterone) in young people, so that explanation does not add up. While Peat has not directly written...- haidut
- Thread
- chronic stress decline depletion dhea dhea-s lower mild stress response stress
- Replies: 12
- Forum: Scientific Studies
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Optimal Dose Of Pregnenolone For Androgen Synthesis
There was a recent discussion about high dose pregnenolone on the forum and some people sent Peat my comments that high dose pregnenolone can inhibit androgen synthesis. Peat replied that he has not seen such effects, but did not directly speak against the idea. Privately, I got quite a few...- haidut
- Thread
- androgen androstenedione concentration dhea optimal pregnenolone progesterone synthesis topical
- Replies: 136
- Forum: Scientific Studies
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FDA Approved First Drug Containing DHEA
I knew it was coming, the evidence in favor of DHEA is just too strong to ignore and the pharma companies are desperate for something that works. The bad news is that the more drugs based on DHEA that appear the more reason and clout FDA acquires to eventually start controlling sales of DHEA...- haidut
- Thread
- approval atrophy dhea fda intercourse intrarosa menopause painful prasterone vaginal vulvar vva
- Replies: 9
- Forum: Scientific Studies
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Raising Serum Androgens Using DHEA, Pregnenolone, And Vitamin K
User testimony (4/26/2021): My Experiences With Raising Androgens Log (Pansterone, k2, magnoil) Many people use supplements like DHEA, pregnenolone, and progesterone with the goal of raising their androgens and lowering estrogen. While this approach works for raising tissue levels of steroids...- haidut
- Thread
- androgens androstenedione aromatase dhea dht gonads hypogonadism menaquinone pregnenolone serum steroidogenesis synthesis testosterone vitamin k vitamin k2
- Replies: 444
- Forum: Scientific Studies