depression

  1. haidut

    Emotional Response To Pain Is Driven By Serotonin And Prostaglandins

    I posted previously on how serotonin is required for the formation of traumatic memories. This process plays a major role in disorders like depression, PTSD, chronic anxiety and even schizophrenia. Serotonin Is Involved In The Formation Of Traumatic Memories This study shows that the activation...
    • haidut
    • Thread
    • aspirin depression emotional pain prostaglandin response serotonin trauma
    • Replies: 14
    • Forum: Scientific Studies
  2. P

    Insulin Resistance In Brain Alters Dopamine Turnover, Causes Behavioral Disorders,anxiety,Depression

    Insulin resistance in brain alters dopamine turnover and causes behavioral disorders. - PubMed - NCBI Diabetes and insulin resistance are associated with altered brain imaging, depression, and increased rates of age-related cognitive impairment. Here we demonstrate that mice with a...
  3. haidut

    The Antidepressant Mechanism Of Androsterone

    There is solid evidence that androgens have potent antidepressant effects in both sexes. However, the mechanism of action of that antidepressant effect has not been fully elucidated yet. On the other hand, it is also well known that chemicals that increase the levels of the so-called...
    • haidut
    • Thread
    • anabolic androgen androsterone antidepressant bdnf depression estradiol estrogen hpa stress
    • Replies: 20
    • Forum: Scientific Studies
  4. P

    Creatine, Similar To Ketamine, Counteracts Depressive-Like Behavior Induced By Corticosterone Via PI

    Creatine, Similar to Ketamine, Counteracts Depressive-Like Behavior Induced by Corticosterone via PI3K/Akt/mTOR Pathway. - PubMed - NCBI Ketamine has emerged as a novel strategy to treat refractory depression, producing rapid remission, but elicits some side effects that limit its use. In an...
  5. P

    Evidence For The Involvement Of 5-HT1A Receptor In The Acute Antidepressant-like Effect Of Creatine

    Evidence for the involvement of 5-HT1A receptor in the acute antidepressant-like effect of creatine in mice. - PubMed - NCBI Creatine was previously shown to produce an antidepressant-like effect in the tail suspension test through a modulation of the dopaminergic system. In this study, the...
  6. haidut

    Pregnenolone As A Treatment For Loneliness

    I touched upon this idea/topic in some of my other posts, and just like those other posts, I would like to emphasize here that I am not suggesting steroid supplementation as a substitute for social interaction. The purpose of this post if to provide some insight on the biochemical effects of...
    • haidut
    • Thread
    • 5a-dhp 5α-dhp 5α-dihydroprogesterone allopregnanolone depression hpa loneliness mental health pregnenolone progesterone social isolation
    • Replies: 52
    • Forum: Scientific Studies
  7. haidut

    Depression Affects The Digestive System Health, Anxiety The Skin

    Ray has written quite extensively on the connection between intestinal inflammation and both mental disorders as well as skin health. There is a quote from him often appearing on the front page saying something along the lines that the health of the intestine is reflected in the physiology of...
    • haidut
    • Thread
    • anxiety arthritis cvd depression digestion digestive tract gi mental health physiology skin
    • Replies: 0
    • Forum: Scientific Studies
  8. Koveras

    The Role Of Steroids In The Prediction Of Affective Disorders In Adult Men

    https://www.ncbi.nlm.nih.gov/pubmed/27871861?dopt=Abstract
    • Koveras
    • Thread
    • allopregnanolone androsterone anxiety depression pregnenolone progesterone steroids testosterone
    • Replies: 13
    • Forum: Scientific Studies
  9. haidut

    Aspirin Treats Depression By Lowering Cortisol And Inflammation

    This was an animal study but it follows a long thread of other studies and some of them with humans. Unfortunately, so far all of the human studies used aspirin only as an adjuvant but hopefully as new studies like the one below continue to appear the opinion on aspirin will change. Ray has...
    • haidut
    • Thread
    • antidepressant aspirin cortisol crf crh depression inflammation interferon
    • Replies: 9
    • Forum: Scientific Studies
  10. haidut

    Theanine May Treat Depression In Humans

    It is a human study, and it used a relatively low dose theanine - only 250mg daily for 8 weeks. Theanine improved virtually all symptoms including actual symptoms of depression, anxiety, and cognitive function. I wonder what would double that dose have achieved given the study I posted about...
    • haidut
    • Thread
    • anxiety cognitive function depression dopamine human major depression mdd serotonin study theanine
    • Replies: 35
    • Forum: Scientific Studies
  11. haidut

    Taurine May Treat Depression And Psychosis In Humans

    A human study, and as such very relevant. The dose (4g daily for 12 weeks) was a bit on the high end but that was probably because the scientists designing the trial were unaware of the studies showing benefits of taurine plateau after 2g daily. In any event, good news for those with mood/mental...
    • haidut
    • Thread
    • cognition depression psychosis schizophrenia study taurine
    • Replies: 8
    • Forum: Scientific Studies
  12. M

    Depression/Anxiety Caused By Systemic Inflammation?

    I came across this interesting article* today. There's something appealing in the idea that awful things like depression, and potentially anxiety, could ultimately come down to inflammation caused by seed oils and such, perhaps because, if true, it should be a simple problem to overcome. Stop...
    • member 2106
    • Thread
    • depression inflammation tnf
    • Replies: 17
    • Forum: Mental Issues
  13. haidut

    Androsterone - An Andidepressant Neurosteroid

    The neurosteroid DHEA has a well-known and studied anti-depressant effect. Several studies have been done in humans using relative high doses of DHEA (50mg - 450mg daily) and they all found positive effects of DHEA on depression. Dehydroepiandrosterone monotherapy in midlife-onset major and...
  14. haidut

    Treatment-resistant Depression Caused By Metabolic Dysfunction

    While the news article quotes one of the more notable cases caused by folic acid deficiency, the study actually looked at a broader metabolic picture and found improvements in all people who got treated for the specific metabolic dysfunction. So, the conclusion at least from this study is quite...
    • haidut
    • Thread
    • brain depression disease dysfunction metabolic remission thyroid treatment
    • Replies: 1
    • Forum: Scientific Studies
  15. haidut

    The Darker Side Of Serotonin Finally Exposed - It Increases Anxiety And Suicide

    I guess the fact that such studies are finally starting to come out is a good sign. I don't think this will hurt Prozac sales in any way, but at least now doctors may start to discuss with patients the potential dangers of SSRI, which up until last year were considered to be pure myth. It still...
  16. haidut

    Blocking Blue Light Can Cure Bipolar Disorder

    This is another great study for so many reasons. First, it adds to the evidence that bipolar disorder is probably environmental in origin, possibly linked to blue light pollution. Second, it adds to the evidence for a link between high cortisol / serotonin and bipolar disorder as blue light...
    • haidut
    • Thread
    • amber glasses bipolar disorder blocking blue light depression red light study treatment
    • Replies: 19
    • Forum: Scientific Studies
  17. haidut

    About 40% Of People With Severe Depression Recover Naturally And Completely

    This study combined with the one I just posted on the dangers of SSRI should make anyone seriously think about what (if any) drug to consider for depression. It reminds me of the study that 80% of the people with "severe" addiction recover on their own completely and do not need any drugs or...
  18. haidut

    Pregnenolone May Protect Cognition From Damage By Stress

    The study was actually on how stress damages cognition, and based on another study I posted and the drug used in the study to block the effects of stress I inferred that pregnenolone would work just as well. The study discovered that the release of CRF / CRH as part of the stress response is...
    • haidut
    • Thread
    • cognition crf crh dementia depression pregnenolone schizophrenia stress
    • Replies: 2
    • Forum: Scientific Studies
  19. haidut

    Depression May Be Caused By Estrogen In Females And Cortisol In Males

    A very interesting study, which points to a potential difference in the depression etiology between the sexes. However, given that cortisol is one of the strong activators of the aromatase enzyme, high cortisol also means high estrogen in males. The study openly discusses the effect of stress on...
    • haidut
    • Thread
    • cortisol crf depression estrogen female males serotonin tph tph1
    • Replies: 35
    • Forum: Scientific Studies
  20. haidut

    Poverty Causes Depression By Increasing Serotonin Activity

    The conditions of learned helplessness and PTSD have many features in common and both of them have been linked to dysfunction of the monoaminergic system. There has been a lot of research over the last decade tying adverse life conditions in childhood to mood and memory problems as an adult...
    • haidut
    • Thread
    • depression methylation poverty serotonin sert slc6a4 stress
    • Replies: 53
    • Forum: Scientific Studies
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