1. haidut

    Stress causes/exacerbates allergies, pregnenolone/progesterone therapeutic

    Yet another studies demonstrating the "controversial" link between stress and a condition doctors insist has nothing to do with stress or hormones in general. This time the culprit is CRF/CRH, which is the initial step in the "stress" cascade and is now known to be implicated in conditions such...
  2. haidut

    Aspirin Treats Depression By Lowering Cortisol And Inflammation

    This was an animal study but it follows a long thread of other studies and some of them with humans. Unfortunately, so far all of the human studies used aspirin only as an adjuvant but hopefully as new studies like the one below continue to appear the opinion on aspirin will change. Ray has...
  3. haidut

    Pregnenolone May Protect Cognition From Damage By Stress

    The study was actually on how stress damages cognition, and based on another study I posted and the drug used in the study to block the effects of stress I inferred that pregnenolone would work just as well. The study discovered that the release of CRF / CRH as part of the stress response is...
  4. haidut

    Depression May Be Caused By Estrogen In Females And Cortisol In Males

    A very interesting study, which points to a potential difference in the depression etiology between the sexes. However, given that cortisol is one of the strong activators of the aromatase enzyme, high cortisol also means high estrogen in males. The study openly discusses the effect of stress on...
  5. haidut

    Pregnenolone Is The Most Potent Inhibitor Of The Stress Signal (CRH)

    I think this study should finally put to rest the arguments and debates of whether pregnenolone raises or lowers cortisol, and how it affects the stress response overall. I posted a similar study, which showed that the pregnenolone metabolites progesterone and allopregannolone potently inhibited...