choline

  1. AlphaCog

    Dietary choline intake is necessary to prevent systems-wide organ pathology and reduce Alzheimer's disease hallmarks

    Abstract There is an urgent need to identify modifiable environmental risk factors that reduce the incidence of Alzheimer's disease (AD). The B-like vitamin choline plays key roles in body- and brain-related functions. Choline produced endogenously by the phosphatidylethanolamine...
    • AlphaCog
    • Thread
    • alzheimer choline organ pathology
    • Replies: 14
    • Forum: Debate
  2. AlphaCog

    Urolithiasis in rats consuming a dl bitartrate form of choline in a purified diet

    Abstract Urolithiasis appeared in rats maintained to study the effects of nutrients and methylmercury on development and aging. After a year, the mortality rate was approximately 10%, and by 2 years, it had increased to nearly 30%. Clinical signs and urinary tract pathology were examined as a...
    • AlphaCog
    • Thread
    • choline choline bitartrate choline-dl-bitartrate methylmercury nephrotoxic urolithiasis
    • Replies: 0
    • Forum: Scientific Studies
  3. mmartian

    Eggs/Choline Causing Twitching in Calf & Jaw/Tooth Pain

    I've been having a battle with eggs and choline. I started realizing that eggs help me sleep, but ever since I ate 7 eggs in one day 2 years ago (and got a short bout of insomnia from that large amount), I started having constant small, painless twitching mostly in my leg calf muscles. I also...
  4. Limon9

    Vitamin D Reduces TMAO From High-Choline Diet, Promotes Non-Atherogenic Microbiome

    The role of trimethylamine n-oxide (TMAO) in human disease has been quite controversial. The carnitine/choline in red meat and eggs had been purported to generate trimethylamine (TMA) via bacterial metabolism, which then goes on to become TMAO via the action of hepatic FMO3. The often-promoted...
    • Limon9
    • Thread
    • antibiotics bacteria choline microbiome testosterone tma tmao vitamin d vitamin d3
    • Replies: 3
    • Forum: Scientific Studies
  5. Sitaruîm

    Coffee and Cholinesterase (AChE)

    In Ray's article about learned helplessness, arguably his most important article, one of the main points seems to be that low cholinesterase leads to overexcitation of the nerves and to cell death. He cites articles that show that rats living in idyllic environments have high levels of...
    • Sitaruîm
    • Thread
    • acetylcholine acetylcholinesterase caffeine choline cholinergic coffee tea
    • Replies: 2
    • Forum: Coffee
  6. InChristAlone

    Acetylcholinesterase info (nightshade sensitivity)

    Since there has been a lot of hype about choline lately, I thought I’d bring back some balance to the topic in talking about excessive acetylcholine. Having choline in the diet doesn’t necessarily cause too much acetylcholine but it is something to be aware of. I found this really interesting...
    • InChristAlone
    • Thread
    • acetylcholine acetylcholinesterase choline nightshades solanine
    • Replies: 44
    • Forum: Health
  7. David PS

    Choline: An Essential Nutrient for Public Health that we’re not getting enough of in our diet

    We were discussing choline at page 4 of another thread and we thought it was worthy of its own thread. According to the National Institutes of HealthTrusted Source, choline is an essential nutrient found in many foods. The brain and nervous system use it to regulate functions that include...
    • David PS
    • Thread
    • acetylcholine choline
    • Replies: 172
    • Forum: Diet
  8. L

    Does piracetam supplementation increase the need for choline?

    I cannot eat eggs (including the yolk) and dairy products, and my main source of choline is lots of red meat. Would it be o.k. to take piracetam in this case? I don’t want to supplement with choline. I don’t intend to take high doses of piracetam, probably around 1-2.4 gram doses every day for a...
  9. Charlieb91

    Is piracetam potentially dangerous?

    Overdosing abuse is usually the culprit in many of these horror stories but it does raise abit of concern when the anecdotal permanent effects are brain fog, depression and even schizophrenia. Piracetam advocates are aware of this small fraction of people who have suffered these effects and...
  10. J

    Damaged Gut, High Serotonin, Standard protocols dont work

    Hello, I am experiencing very high serotonin symptoms. I have very low sex drive, brain fog, no drive, I take a dump many times in a day and I have a very white coated tongue at the back of the tongue with cuts. I am sure this is my main problem now, because yesterday I did a test. I reduced my...
  11. RenaissanceMan

    CDP-Choline enhances cerebral glucose metabolism, increases cerebral blood flow rate & brain ATP, & decreases the accumulation of lactate in the brain

    I know Ray is against choline supplementation but many nootropics users have had positive experiences with it for improving motivation, memory, and overall cognition. CDP-Choline breaks down into uridine which has many dopaminergic effects on the body as well. @Hans wrote an article on this...
    • RenaissanceMan
    • Thread
    • acetylcholine cdp-choline choline citicoline cognizin nootropic nootropics
    • Replies: 36
    • Forum: Debate
  12. pauljacob

    Eggs Under Attack Again

    An short article in the Atlantic says that intestinal bacteria convert Choline in eggs into a compound that correlates strongly with heart disease, stroke, and death. The study implicates Carnitine and Choline. It seems that business-backed studies are hitting on eggs again as a killer. Here's...
  13. haidut

    Damaged Mitochondria And Endotoxin (LPS) Drive Chronic Inflammation

    Chronic, low-grade inflammation has now been recognized as the main cause behind a number of chronic degenerative conditions including CVD, diabetes, cancer, Alzheimer, Parkinson, etc. Mainstream medicine claims that the cause of this chronic low-grade inflammatory reaction is unknown, despite...
    • haidut
    • Thread
    • choline chronic damage endotoxin inflammation lps mitochondria mitophagy stress tlr4
    • Replies: 5
    • Forum: Scientific Studies
  14. Amazoniac

    Incomprehensive/ble Notes On Choline

    ..and why avoiding eggs due to a couple grams of PUFAs might not be a good idea. They're not the only source, but are by far the best since livers aren't ideal for regular consumption. Finding pastured eggs locally and online - Toxinless These were all over of the places. I figured it could be...
  15. P

    Skeletal Muscle Phosphatidylcholine And Phosphatidylethanolamine Are Related To Insulin Sensitivity

    And the difference is big! 100% and 50% for each ,compared to subjects with higher insulin sensitivity. Egg yolks/milk and liver are rich source of these phospholipids. But yolks are the richest. Skeletal muscle phosphatidylcholine and phosphatidylethanolamine are related to insulin...
    • paymanz
    • Thread
    • choline diabetes eggs folate insulin sensitivity magnesium membrane fluidity milk phosphatidylcholine phosphatidylethanolamine phosphatidylserine phospholipid pufa saturated fat sphingomyelin taurine vitamin a vitamin k zinc
    • Replies: 58
    • Forum: Articles & Scientific Studies
  16. P

    Betaine Lowers FFA And Improve Insulin Sensitivity And Adiponectine Level In High Fat Fed Animal

    Betaine improved adipose tissue function in mice fed a high-fat diet: a mechanism for hepatoprotective effect of betaine in nonalcoholic fatty liver disease Endoplasmic reticulum (ER) stress plays a critical role in adipose tissue dysfunction and insulin resistance in a variety of experimental...
    • paymanz
    • Thread
    • adiponectin betaine choline diabetes fibrosis free fatty acids insulin resistance insulin sensitivity jnk leptin liver disease liver steatosis resistin
    • Replies: 7
    • Forum: Articles & Scientific Studies
  17. haidut

    Supplementary Choline Raises Risk Of Blood Clots; Aspirin To The Rescue

    Ray has written about the dangers of choline and its close relationship with estrogen. The histamine and acetylcholine receptors are perhaps the two main systems through which estrogen negatively affects the systemic health of the organism. As such, antihistamine and antocholinergic drugs can...
    • haidut
    • Thread
    • blood clotting carnitine choline cvd diet endotoxin gut flora microbiome platelet aggregation risk tmao
    • Replies: 60
    • Forum: Scientific Studies
  18. Luann

    Not Low Carb, But Lack Of Choline And Methionine, Cause Keto Success

    http://www.sciencedirect.com/science/article/pii/S221287781300063X In this study we examined the role of methionine and choline in mediating the metabolic effects of KD. We have found that choline was more effective than methionine in decreasing the liver steatosis of KD-fed mice. On the other...
  19. haidut

    Acetylcholine Has Negative Effects On Gonadal Steroidogenesis

    Choline and acetylcholine are another topic that often pops up online. Cholinergic drugs are still the main "treatment" for Alzheimer, even though all of them are abject failure clinically. Ray has written about the excititoxic properties of acetylcholine, and how estrogen manifests its effects...
    • haidut
    • Thread
    • androgen synthesis choline inhibition leydig nicotine receptors steroid study testicular testosterone
    • Replies: 40
    • Forum: Scientific Studies
  20. Westside PUFAs

    Study Finds Choline Promotes Cardiovascular Disease

    http://www.ncbi.nlm.nih.gov/pubmed/21475195
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