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"Several other synthetic estrogenic substances, ethynylestradiol, lindane, PCBs, cause eggshell thinning, partly by altering carbonic anhydrase activity (Holm, et al, 2006). Estrogen and serotonin activate carbonic anhydrase in some tissues, progesterone tends to inhibit it."
-Ray Peat
Peat has...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226357/
Abstract
Carbonic anhydrase II (CAII) is a metalloenzyme that catalyzes the reversible hydration/dehydration of CO2/HCO3−. In addition, CAII is attributed to other catalytic reactions, including esterase activity. Aspirin (acetyl-salicylic...
The ongoing Covid-19 is a contagious disease, and it is characterised by different symptoms such as fever, cough, and shortness of breath. Rising concerns about Covid-19 have severely affected the healthcare system in all countries as the Covid-19 outbreak has developed at a rapid rate all...
In support of Ray's views of CO2 as one of the main factors in mitochondrial biogenesis and health, and as such in a host of health conditions, this study found that carbonic anhydrase levels are higher and the enzyme itself is more active in both aging and degenerative conditions. Inhibiting...
It looks like both the H2 antagonists and the PPI drugs ara capable of inhibiting CA in vivo. This would explain some of the positive findings in studies testing PPI and H2 blockers in cancer and mental disease.
This study compared omeprazole, famotidine and ranitidine for inhibition of CA...
After findings the studies on synergism between thiamine and acetazolamide, and their combined use in a number of diseases I became intrigued. Then the wild thought just came out of nowhere - what if thiamine was also a carbonic anhydrase inhibitor but at different isoenzymes and with different...
Eriocitrin and Apigenin as New Carbonic Anhydrase VA Inhibitors from a Virtual Screening of Calabrian Natural Products.
ABSTRACT In this work, we performed a structure-based virtual screening against five carbonic anhydrase isoforms using, as a ligand library, natural components of Citrus...
Another point for caffeine, even though the reported effectiveness is weak. I always wondered why I seemed to get similar effects on breathing (shallower and more efficient) form caffeine and acetazolamide.
http://www.ncbi.nlm.nih.gov/pubmed/21612376
"...Caffeine and piperine were extracted...