1. A

    Carbogen inhalation opens the blood-brain barrier

    Abstract The blood-brain barrier (BBB) prevents many drugs from entering the brain. Yet, conventional methods that open the BBB are technically demanding, poorly reversible, and can be associated with long-term adverse effects. In comparison, carbogen, which is introduced nearly a century ago as...
  2. Mauritio

    Serotonin, PUFA and histamine increase leaky brain

    This is just just another angle showing how stress hormones and PUFA affect the whole body negatively. Increased Blood-brain-barrier permeability(leaky brain) is linked to many diseases : "Blood–brain barrier dysfunction contributes to pathology in a range of neurological conditions including...
  3. M

    How To Treat Leaky Blood-brain-barrier If One Is Sensitive To Caffeine Pill?

    So I believe that I have been suffering from leaky BBB. I saw some of the suggested solutions being chronic high caffeine level in the body. I have previously had serotonin toxicity issues and have had heart issues due to other chemicals (tretinoin) etc. I am sensitive to caffeine pill, ex. I...
  4. M

    Forced Swimming Increases Serotonin Which Increases The Permeability Of The BBB

    This below study shows that forced swimming increases serotonin. I post this because often people claim that plasma serotonin and gut serotonin have an inverse relationship. This study shows that the severe stress that those young rats endured increased both their plasma and brain serotonin, and...
  5. haidut

    Fats Cause Cause Cognitive Impairment And Insulin Resistance In The Brain

    The topic of whether fats cross the BBB is very controversial, especially in light of recent evidence that dementias like Alzheimer are simply so-called "diabetes of the brain". It is well-known in clinical circles that fats do cause insulin resistance, but the PUFA lobby is powerful enough to...
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