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  1. haidut

    Niacinamide may prevent neurodegeneration

    Yet another study demonstrating that maintaining high energy levels through OXPHOS is crucial for health, in this case brain health. There are many studies, going back decades, demonstrating that a drop in NAD+ levels, and thus of NAD/NADH and, consequently, of OXPHOS is a common feature of...
  2. haidut

    Aspirin may treat (idiopathic) pulmonary fibrosis (PF)

    I mentioned in several of my latest podcast appearances that Pfizer is running clinical trials with a serotonin antagonist to reverse/treat several lethal conditions, for which medicine claims there is no cure. Those conditions include heart fibrosis / heart failure, pulmonary hypertension...
  3. haidut

    Vitamin B3 counteracts (cancer) cachexia, by restoring NAD+ levels

    As many of my readers know, the majority of cancer patients do not succumb from the actual tumor burden, but as a result of (usually in that order) cachexia, immunocompromise from radiation/chemotherapy, hospital-acquired infection, and/or cytokine storm after surgery for removing the tumor. Of...
  4. haidut

    Aspirin may replicate the benefits of fasting, while avoiding its risks

    I just made a post about fasting raising risk of early death by about 30%. On the other hand, fasting has been shown to lower biomarkers of inflammation as well as increase autophagy, with at least the former being undeniably beneficial. We already know from other studies that the benefits of...
  5. haidut

    Serotonin, SSRI drugs may be the cause of IBD, Parkinson's, diabetes, etc.

    A great new study that points the finger straight at serotonin (5-HT). It has been known since the 1940s that not only is 5-HT produced predominantly in the GI tract, but also that elevated serotonin levels are causally linked to a plethora of chronic conditions, especially various inflammatory...
  6. P

    “NO” To Autophagy: Fat Does The Trick For Diabetes

    “NO” to Autophagy: Fat Does the Trick for Diabetes During the progression from obesity to diabetes, a critical attribute is inability to maintain metabolic homeostasis under excessive energy and nutrient exposure, which triggers insulin resistance. Intensive research efforts have linked chronic...
  7. P

    Aspirin Alleviates Cardiac Fibrosis In Mice By Inhibiting Autophagy

    Aspirin alleviates cardiac fibrosis in mice by inhibiting autophagy. - PubMed - NCBI Acta Pharmacol Sin. 2017 Apr;38(4):488-497. doi: 10.1038/aps.2016.143. Epub 2017 Feb 20. Aspirin alleviates cardiac fibrosis in mice by inhibiting autophagy. Liu PP1, Liu HH2, Sun SH3, Shi XX2, Yang WC2, Su...
  8. S

    Circadian Autophagy, Fat Liver, Lithium And Caffeine

    Atg7 complementation resulted in reduced hepatic fatty acid infiltration ( Figures 6A and 6B), liver triglyceride content ( Figure 6C), and serum insulin level ( Figure 6D). There was a modest increase in serum triglyceride, but not free fatty acid levels, in mice expressing exogenous Atg7 (...
  9. K

    Caffeine Increases Autophagy

    I think this is a very interesting article: http://www.anti-agingfirewalls.com/2013 ... s-aging-2/ It talks about possible health benefits of caffeine by increasing autophagy. I've heard many good things about autophagy, but not really from Ray Peat. I wonder what you guys think about this. A...