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atrophy

  1. haidut

    Allopregnanolone found safe, may slow brain atrophy from Alzheimer's

    A great new study, which is one of the very few to examine the safety and effectiveness of allopregnanolone in humans. The trial was conducted in patients with Alzheimer Disease (AD) and aimed to establish the safety of various doses of once-weekly allopregnanolone administration, as well as any...
    • haidut
    • Thread
    • allopregnanolone alzheimer atrophy brain cognitive dementia neurogenesis
    • Replies: 5
    • Forum: Scientific Studies
  2. haidut

    Fasting / stress decimate gonadal steroidogenesis, with no effect on blood cortisol

    A very interesting and very "controversial" (read: inconvenient truth) study, since it shows beyond reasonable doubt that even brief (4 days) fasting is a form of severe stress, at least when it comes to endocrine health. The study may also provide answers to various endocrine "mysteries"...
    • haidut
    • Thread
    • androgen atrophy cortisol fasting gonads hypogonadism stress
    • Replies: 14
    • Forum: Scientific Studies
  3. haidut

    Muscle weakness / wasting linked to poor mitochondrial function

    A study that once again illustrates the central principle of bioenergetics - structure and function cannot be separated. They are interdependent at every level. In this specific case, the "structural" pathology is muscle weakness and wasting (sarcopenia, cachexia, etc). Most doctors, when...
    • haidut
    • Thread
    • atp atrophy cachexia metabolism mitochondria muscle weakness oxphos sarcopenia
    • Replies: 2
    • Forum: Scientific Studies
  4. haidut

    Pregnenolone (P5) Fully Prevents Testicular Atrophy Due To Steroid (ab)use Or High Estrogen

    I often get emails from bodybuilders, athletes and others who have used or currently use steroids and want to either protect themselves while using those steroids or want to recover after long-term usage. It is well-known that most performance enhancing steroids, including plain testosterone (T)...
    • haidut
    • Thread
    • atrophy estradiol estrogen gonads ovaries p5 pregnenolone suppression testicles testosterone
    • Replies: 85
    • Forum: Scientific Studies
  5. haidut

    Estrogen And Cortisol, Not Androgens, Suppress Immunity

    There is a very famous theory in reproductive biology still considered the dominant one in its field. Namely, males have to accept a trade-off between androgen levels and immunity. It is known as the immunocompetence handicap hypothesis (ICHH). Higher androgen levels, the theory goes, allow the...
    • haidut
    • Thread
    • aging androgen aromatase inhbitor atrophy cortisol dhea disease estrogen immunity progesterone suppression thymus
    • Replies: 1
    • Forum: Scientific Studies
  6. P

    Action Of Topical Thyroid Hormone Analogue In Reversing Glucocorticoid-induced Skin Atrophy

    Action of topical thyroid hormone analogue, triiodothyroacetic acid in reversing glucocorticoid-induced skin atrophy in humans. - PubMed - NCBI Abstract The present study concerns the effect of topical treatment with a cream formulation of triiodothyroacetic acid (TRIAC) in comparison with a...
  7. haidut

    FDA Approved First Drug Containing DHEA

    I knew it was coming, the evidence in favor of DHEA is just too strong to ignore and the pharma companies are desperate for something that works. The bad news is that the more drugs based on DHEA that appear the more reason and clout FDA acquires to eventually start controlling sales of DHEA...
    • haidut
    • Thread
    • approval atrophy dhea fda intercourse intrarosa menopause painful prasterone vaginal vulvar vva
    • Replies: 9
    • Forum: Scientific Studies
  8. haidut

    Low-dose Glycine As A Treatment For Menopause, Osteoporosis, Obesity

    This study is a great find IMO but unfortunately it uses the elevations in blood levels of estrogen as a reason to label glycine as estrogenic, which is wrong. Just like progesterone, glycine can trigger release of estrogen from tissues/cells and this elevates the blood levels while lowering it...
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