atherosclerosis

  1. haidut

    Cortisol stimulates its own synthesis (peripherally), drives obesity/diabetes/CVD

    Synthetic/bioidentical glucocorticoids (GC) are perhaps the most widely used steroids clinically. In addition, the HPA axis, culminating in cortisol production, is one of the most widely studied mechanisms in regards to many chronic diseases including obesity, diabetes, CVD, mental conditions...
  2. Mauritio

    MAO-B / Serotonin causes atherosclerosis, Selegiline treats

    Research on Selegiline seems to be picking up and researchers are now using it for all kinds of disorders like fatty liver disease or atherosclerosis, not just Parkinson's and anti-aging. This study looked the causes of atherosclerosis and if MAO-B has something to do with it. It turned it, it...
  3. haidut

    Raising DHT levels even only in the brain reverses systemic atherosclerosis

    As my readers know, I have been a fan of the strong, non-aromatizable androgen DHT for a long time. One of the first signs for me that DHT is beneficial was the uniform and relentless propaganda against that steroid by mainstream medical publications, despite the obvious (and increasing)...
  4. haidut

    Atherosclerosis linked to high estrogen/cortisol/serotonin, low androgens

    The findings of the study are not surprising, but I wanted to post it on the blog since it is one of the few studies I have seen that examined more than one of the "sickness" mediator levels in a major chronic conditions such as cardiovascular disease (CVD), and found all of them to be elevated...
  5. UG Krishnamurti

    Dietary Ca or Ca/P during inflammation will increase calcification and microcalcification?

    When I am in inflamed state I always felt extremely worse if I drink milk for example. The symptoms I experience were intestinal bleeding (I have Crohn's), extreme scalp hardness, psoriasis getting worse, fatigue, cramping etc. Even just drinking plain mineral water higher in calcium created...
  6. UG Krishnamurti

    Wishing this man the best but what can we learn from looking at his markers?

    "How the f*ck did I have three blocked arteries?? I fasted, ate low carb, cut seed oils, did cardio and weights at least 5x a week. End result…. My widow maker was 95% blocked?? thank the Lord I just happened to go to cardiologist after iwatch reported afib" LINK TO THE TWITTER POST Take a...
  7. UG Krishnamurti

    Heated saturated fats increase inflammation and lead to atherosclerosis?

    My experience so far has been that fried/heated saturated fats (coconut/butter) increase stiffness, pain and inflammation in the body. I believe that interactions is worse if there is some kind of inflammation in the body prior to ingesting the saturated fats (This is problematic to someone with...
  8. A

    The homeoviscous adaptation to dietary lipids (HADL) model explains controversies over saturated fat, cholesterol, and cardiovascular disease risk

    SFAs play the leading role in 1 of the greatest controversies in nutrition science. Relative to PUFAs, SFAs generally increase circulating concentrations of LDL cholesterol, a risk factor for atherosclerotic cardiovascular disease (ASCVD). However, the purpose of regulatory mechanisms that...
  9. miraddo

    Men store up to 4.6 times more Iron than age-matched women

    https://pubmed.ncbi.nlm.nih.gov/11995291/ "This article summarizes research conducted during the last 2 decades that addresses the idea that stored iron plays a role in the pathogenesis of atherosclerosis and that iron reduction through phlebotomy may play a role in the treatment or prevention...
  10. Mito

    Evidence For Apo B Lipoproteins As The Root Cause Of Atherosclerosis

    “A new paradigm for preventing atherosclerotic cardiovascula disease (ASCVD) is needed. The most recent US data show the long-term decline in cardiovascular deaths has stopped, and has started to increase in the most at-risk populations.1 Indeed, rising rates of obesity and diabetes mellitus in...
  11. haidut

    Endotoxin Causes (liver) Steatosis, Insulin Resistance And Atherosclerosis

    I know this study was in hepatitis C patients only, but there is nothing about Hep C that would invalidate this finding in the general population too. Quite a few people on the forum reported that when they tried to talk to their doctor about endotoxin and its possible role in their health...
  12. haidut

    Endotoxin (LPS) Theory Of Atherosclerosis (CVD)

    I posted a study more than year ago, which examined the role of NO in aging and disease. The Nitric Oxide (NO) Theory Of Aging One of the main endogenous stimulators of NO synthesis is endotoxin (LPS). It turns out that the connection between LPS and CVD has been studied for a long time in...
  13. raypeatclips

    Magnesium Chloride Modulates Atherogenesis, Atherosclerosis

    Atherogenesis inhibition induced by magnesium-chloride fortification of drinking water. - PubMed - NCBI Biol Trace Elem Res. 2002 Winter;90(1-3):251-9. Atherogenesis inhibition induced by magnesium-chloride fortification of drinking water. Cohen H1, Sherer Y, Shaish A, Shoenfeld Y, Levkovitz...
  14. haidut

    Grey Hair May Be A Biomarker For CVD (and Biological Age) In Men

    Ray has written about the role of low copper, high serotonin, and generally low thyroid function in changing hair color from dark (or blonde) into white with advancing age. It just so happens, that these phenomena also affect heart health. I have long suspected that premature greying of hair on...
  15. P

    The Relationship Between Serum Level Of Manganese And Severity Of Coronary Atherosclerosis

    http://www.zjrms.ir/article-1-2972-en.html Background : Trace elements such as manganese have an important role in the maintenance of the normal structure and physiology of cells. Manganese is involved in many biological processes. Therefore, an evaluation of the manganese in the...
  16. haidut

    Androsterone As A Thyromimetic Treatment For Gout And CVD

    These studies are old, but I am just posting them here as further support of the thyromimetic properties of androsterone. As we know, thyroid hormone is the primary regulator of levels of uric acid and serum lipids and Ray has recommended improvement of thyroid function as the primary method for...
  17. P

    Cortisol Decreases The Synthesis Of Hyaluronic Acid By Human Aortic Smooth Muscle Cells In Culture

    Cortisol decreases the synthesis of hyaluronic acid by human aortic smooth muscle cells in culture. - PubMed - NCBI The effect of cortisol on the synthesis of glycosaminoglycans (GAGs) was studied in cultured human aortic smooth muscle cells. Cortisol, at a level slightly exceeding the...
  18. haidut

    Positive Impact Of Vitamin B3 On CVD Is Not Due To Lowering Cholesterol

    Comparisons with treatment with niacin to raise HDL and lower LDL has been considered the gold-standard for all new statin drugs. However, it has been shown that both niacin and niacinamide have the same protective effects on cardiovascular disease (CVD) despite the fact that niacinamide has...
  19. J

    High Fat Diet Induced Inflammation, Temperature, And Metabolic Disease

    http://www.cell.com/cell-metabolism/abs ... 50-4131(15)00519-7 "Highlights •Thermoneutral housing accelerates onset of metabolic inflammation •Thermoneutral housing uncouples adipose tissue inflammation from insulin resistance •Atherosclerosis is potentiated in thermoneutral mice...
  20. J

    High Dietary Taurine Reduces Apoptosis And Atherosclerosis In The Left Main Coronary Artery

    High Dietary Taurine Reduces Apoptosis and Atherosclerosis in the Left Main Coronary Artery
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