arachidonic

  1. haidut

    PUFA Enhance Glucocorticoid (cortisol) Signalling

    I posted some studied in the past on the estrogenic and pro-cortisol effects of PUFA, as well as the pro-androgen effects of SFA. One of those studies showed that PUFA increases cortisol synthesis even in the absence of ACTH, which suggests that they may have pituitary hormonal-like effects...
  2. haidut

    PUFA Cause Fatal Swelling Seen In Brain Infections; SFA Are Harmless

    Conditions like meningitis and brain abscess are on the rise and there is currently no explanation why. The fatality of such conditions is usually not due to the infection itself but due to the swelling of the brain, which results in compression of the brainstem and often herniation, both of...
  3. haidut

    PUFA Is Directly Catabolic (without Cortisol/estrogen), SFA Is Anabolic

    I posted a few studies about PUFA potentiating the stress response and cortisol synthesis, even without the typical elevations of ACTH present in organic stress reactions. Saturated fats block that pro-stress effects of PUFA...
  4. haidut

    PUFA Initiate & Promote The Stress Response (ACTH/cortisol), SFA Inhibit It

    Almost two years ago I posted a study showing that PUFA can stimulate cortisol release even in the absence of ACTH. Pufa Stimulates Cortisol Production Even In The Absense Of Acth However, that study above did not look at the effects of saturated fatty acids (SFA) and I keep getting emails...
  5. haidut

    PUFA Is Estrogenic And Androgen/Progesterone Antagonist

    As Peat mentioned many times and I discussed on Danny Roddy's shows, PUFA is a powerful endocrine disruptor. As such, it has direct effects on steroids and expression of steroids receptors in cells that go beyond its metabolism into the inflammatory mediators (even though those amplify the...
  6. haidut

    Inhibition Of PUFA Metabolism (LOX) Trigger Immediate Apoptosis In Prostate Cancer

    These studies show that PUFA has both direct (linoleic) and secondary (through LOX) stimulating effect on prostate cancer growth, independently of any hormones. Inhibiting the LOX-5 pathway led to immediate growth arrest and apoptosis of prostate cancer cells. The important message for both...
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