anxiety

  1. haidut

    Energy Deficiency Due To Stress Causes Anxiety, Panic Disorders, And Subbordination

    This is a great study on so many levels. First, it directly demonstrates that chronic stress leads to mitochondrial dysfunction and reduced oxidative phosphorylation. Second, it demonstrates that glucocorticoids (cortisol) are a direct cause of this energy production downregulation. Third, it...
  2. Mauritio

    Anxiety / Mental Illness Caused By Mitochondria

    Role of mitochondrial uncoupling protein-2 (UCP2) in higher brain functions, neuronal plasticity and network oscillation This is another study along the lines of what @haidut has been posting here for the last years: mental Illnesses are a metabolic problem, start in the mitochondria and (what...
  3. haidut

    Blocking Stress (adrenaline) Just Once Cures PTSD And Maybe Any Mental Disorder

    This is a remarkable study, which once again implicates extreme stress in the pathology of mental health disorders, specifically anxiety and PTSD. Just a few days ago I posted a study showing a high cortisol (C) / testosterone (T) ratio is likely causative in PTSD. People with high C/T ratio...
  4. haidut

    Chronic Stress / Defeat Causes Mental Illness By Damaging Mitochondria

    Yet another study demonstrating that mental illness has little to do with genetics, and is likely entirely due to energetic deficiency caused by environmental stress. This energetic deficiency is caused by mitochondrial damage caused by said stress. Keeping lipolysis and/or PUFA intake low can...
  5. haidut

    Novel (learning) Experiences Can Be A Buffer Against Workplace Stress

    As the forum users know rather well by know, novelty seeking and enjoyment are driven by dopamine and require a significant amount of metabolic energy. Most workplaces, especially large corporations, actively discourage novelty- seeking, behavior or personalities due to the firmly entrenched...
  6. haidut

    The Financial Crisis In 2008 Increased Obesity, Diabetes And Mental Illness

    So much for these issues being "predominantly genetically driven" as mainstream medicine likes to proclaim. It would have been nicer if the authors of the study also tested thyroid function as that would have directly implicated declining metabolism in these health issues strongly linked to...
  7. haidut

    Pollution (and Resulting Anxiety) Predicts Violence And Unethical Behavior

    For those of you who have read the book Freakonomics, you probably remember the chapter discussing the drop in violent crime in the US during the late 80s and early 90s. The authors made the claim that neither better law enforcement, nor social programs were responsible for that drop. Rather...
  8. P

    Blocking Human Fear Memory With The Matrix Metalloproteinase Inhibitor Doxycycline

    Blocking human fear memory with the matrix metalloproteinase inhibitor doxycycline Blocking human fear memory with the matrix metalloproteinase inhibitor doxycycline D R Bach , A Tzovara & J Vunder Molecular Psychiatry doi:10.1038/mp.2017.65 Download Citation Neuroscience Received: 05...
  9. P

    PH Of Soul: How Does Acid-base Balance Affect Our Cognition?

    pH of soul: how does acid-base balance affect our cognition? Abstract Respiratory Alkalosis due to changes in sympathetic hyperarousal during pathological emotional states can change our cognitive abilities. This occurs through the effects of Alkalosis upon cerebral vasoconstriction and the...
  10. haidut

    Intrusive / Unwanted Thoughts Due To Low GABA Signalling

    Peat has mentioned GABA quite a few times in his articles and its role as the chief inhibitory signal in the body, protecting both brain cells and peripheral tissues/organs from excitotoxicity caused by PUFA, glutamate, estrogen, stress, etc. But the role of GABA is especially prominent in the...
  11. haidut

    Intelligent People More Likely To Suffer From Mental Illness

    I have mentioned a few times on the forum that in the "psychiatric bible" DSM IV/V a good mental health is characterized by a mild to moderate delusion, while realism is characterized by a mild to moderate depression. Peat said a few times that people with high IQ have a hard time adjusting to...
  12. haidut

    Stress Just As Bad As High-PUFA Diet For Your Health

    Most doctors consider stress to be an inescapable fact of daily life, but something that is of concern to only genetically pre-disposed people or ones who have CVD. The official version is that for most people stress does NOT cause adverse health outcomes. However, this house of cards has stated...
  13. P

    Anxiety Correlates To Decreased Blood And Prefrontal Cortex IGF-1 Levels In Streptozotocin Induced D

    Anxiety correlates to decreased blood and prefrontal cortex IGF-1 levels in streptozotocin induced diabetes - ScienceDirect Progesterone treatment decreases traumatic brain injury induced anxiety and is correlated with increased serum IGF-1 levels; prefrontal cortex, amy... - PubMed - NCBI...
  14. P

    Fibroblast Growth Factor-2 And Anxiety

    Fibroblast Growth Factor 2 Modulates Hypothalamic Pituitary Axis Activity and Anxiety Behavior Through Glucocorticoid Receptors - ScienceDirect Fibroblast growth factor deficiencies impact anxiety-like behavior and the serotonergic system. - PubMed - NCBI Fibroblast Growth Factor 2 for...
  15. haidut

    SSRI / Serotonin Worsens Tinnitus

    Most of the people on this forum know about the connection between gut irritation and tinnitus. Ray said a few times that endotoxin can directly cause tinnitus but I don't think he has talked about the role of serotonin as a causative agent, even tough endotoxin will increase serotonin synthesis...
  16. P

    Insulin Resistance In Brain Alters Dopamine Turnover, Causes Behavioral Disorders,anxiety,Depression

    Insulin resistance in brain alters dopamine turnover and causes behavioral disorders. - PubMed - NCBI Diabetes and insulin resistance are associated with altered brain imaging, depression, and increased rates of age-related cognitive impairment. Here we demonstrate that mice with a...
  17. DaveFoster

    Tolerance Builds To Caffeine-Induced Anxiety

    The first of the following two studies was done on rats, and the second on humans. It seems that after about 2 weeks, the anxiogenic effects of caffeine diminishes completely as tolerance develops. Coincidentally, this is the time that it takes adenosine receptors to fully upregulate to...
  18. J

    Anxiety And Impulsivity: Factors Associated With Premature Graying In Young Dogs

    http://www.appliedanimalbehaviour.com/article/S0168-1591(16)30277-5/fulltext I know this can happen in humans too, where a stressful event causes the graying of a specific patch of hair and the colour returns spontaneously when the stressful event ends (without the need of any particular diet...
  19. haidut

    Depression Affects The Digestive System Health, Anxiety The Skin

    Ray has written quite extensively on the connection between intestinal inflammation and both mental disorders as well as skin health. There is a quote from him often appearing on the front page saying something along the lines that the health of the intestine is reflected in the physiology of...
  20. Koveras

    The Role Of Steroids In The Prediction Of Affective Disorders In Adult Men

    https://www.ncbi.nlm.nih.gov/pubmed/27871861?dopt=Abstract
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