antagonist

  1. haidut

    Anti-serotonin, Pro-dopamine Drug Approved For Psychosis And Bipolar Disease

    After more than 5 decades of claiming that psychosis conditions like schizophrenia are caused by excessive dopaminergic activity and depression is a deficiency of serotonin, big pharma is doing 180 degrees reversal. A new drug was just approved for treating bipolar disorder and schizophrenia in...
    • haidut
    • Thread
    • agonist antagonist bipolar disorder disease dopamine psychosis schizophrenia serotonin
    • Replies: 22
    • Forum: Scientific Studies
  2. haidut

    Niacinamide Is Anti-estrogenic

    Yet another strong point for niacinamide. I am beginning to wonder if there is any condition or biomarker of disease that niacinamide cannot affect. Peat has written many times about the sirtuin genes and their promoter resveratrol. While there is already quite a bit of evidence that SIRT1...
    • haidut
    • Thread
    • antagonist estrogen fulvestrant hdac inhibition niacinamide sirt1 sirtuins study suppression
    • Replies: 36
    • Forum: Scientific Studies
  3. J

    Ginger Is A Seratonin Antagonist?

    http://suppversity.blogspot.com/2015/07/nausea-leaky-gut-gi-disturbances-ginger.html?m=1 So I read Adel's latest article about ginger helping athletes with respect to ameliorating leaky gut. And at the bottom, Adel mentions speculation that ginger is a seratonin receptor antagonist. I wanted...
  4. haidut

    Progesterone, Testosterone, Allopregnanolone Are Serotonin Antagonists

    This study shows that some of the gonadal steroids act in a manner similar to the drug ondansetron - i.e. antagonize the 5-HT3 "receptor". While pregnenolone sulfate was not antagonistic to 5-HT3, taking pregnenolone metabolizes mostly into progesterone and allopregnanolone. So, it seems like a...
    • haidut
    • Thread
    • 5ht allopregnanolone antagonist progesterone serotonin study testosterone
    • Replies: 24
    • Forum: Scientific Studies
  5. haidut

    Vitamin B6 (P5P) Is A Glucocorticoid (cortisol) Antagonist

    The studies go back to 1960s and 1970s but when I read them I was surprised to find that the activated form of vitamin B6 called pyridoxal-5-phosphate (what we also use for our Energin supplement) is a glucocorticoid "receptor" antagonist. Some of the in vivo studies referenced in the studies...
    • haidut
    • Thread
    • antagonist cortisol glucocorticoid p5p study vitamin b6
    • Replies: 10
    • Forum: Scientific Studies
  6. haidut

    Niacinamide Is Both A Serotonin And Tryptophan Antagonist

    I know this was discussed to a degree in another thread, but this study goes a bit further claiming that as being one of neurokynurenines niacin / niacinamide antagonizes the effects in the brain of both serotonin precursors and serotonin itself. http://www.ncbi.nlm.nih.gov/pubmed/15206724...
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