androgens

  1. haidut

    Cholesterol And SFA Are Anabolic; PUFA/MUFA Akin To Chemical Castration

    A pair of interesting study and a commentary in the highly respected Journals of Gerontology. Namely, higher cholesterol intake is associated with much higher lean muscle mass accrual as a result of weight lifting. Interestingly, higher protein intake was not. Even more interestingly, and much...
    • haidut
    • Thread
    • anabolic androgens anticatabolic castration cholesterol eggs mufa muscle pufa sarcopenia saturated fat sfa
    • Replies: 28
    • Forum: Scientific Studies
  2. haidut

    Pregnenolone Is Anabolic For Bones

    So much for pregnenolone being an inactive steroid. The study below shows that even very low concentrations of pregnenolone are high anabolic for the bone and its effects are comparable to those of potent steroids like DHT or the well-known androgenic-anabolic steroid (AAS) commonly known as...
    • haidut
    • Thread
    • alp anabolic androgens bone bones effects osteocalcin osteoporosis pregnenolone progestins
    • Replies: 15
    • Forum: Scientific Studies
  3. haidut

    The Progesterone-like Action Of Testosterone And Other Androgens

    I am posting this simply as a response to the many hateful comments I got in regards to my discussion of testosterone as a progestin. Peat also alluded to the fact that testosterone has activity on the progesterone receptor and is likely safer as a "progestin" than the synthetic progestins being...
    • haidut
    • Thread
    • androgens dht estrogen antagonist progesterone agonist progesterone receptor progestin testosterone
    • Replies: 9
    • Forum: Scientific Studies
  4. haidut

    Acetaminophen (Tylenol) Depletes DHEA-S And Other Sulfated Steroids

    It is well-known that in animal studies acetaminophen has a potent anti-androgenic and feminizing effect. In some animal models it also reliably causes autism-like symptoms. Given its widespread use and heavy marketing by hospitals, especially to pregnant women (due to its lack of effect on...
    • haidut
    • Thread
    • acetaminophen androgens decrease dhea-s pregnenolone sulfate steroids sulfated tylenol
    • Replies: 18
    • Forum: Scientific Studies
  5. haidut

    Low DHT Levels May Be The Cause Of Wasting In HIV/AIDS

    While these studies only focus on the wasting syndrome in HIV/AIDS patients, the pathology of the wasting is virtually the same in other cachectic conditions including cancer, Cushing, sepsis, etc. If DHT does get approved by the FDA for muscle wasting, we may finally see a change in attitude in...
    • haidut
    • Thread
    • aids androgens cachexia dht hiv testosterone wasting syndrome
    • Replies: 8
    • Forum: Scientific Studies
  6. haidut

    Calcirol - Liquid Vitamin D3

    Just like the other vitamin products we have released, this product does not really need any introduction to anybody familiar with Peat's work. So, unlike other products of ours, there won't be as many references listed in support of this product but I think even the few ones below are enough to...
    • haidut
    • Thread
    • anabolic androgens anti-aging anti-estrogen anticortisol calcirol calcium cholecalciferol klotho secosteroid vitamin d vitamin d3
    • Replies: 362
    • Forum: IdeaLabs
  7. AretnaP

    If You Don't Want Low Testosterone DO NOT FAST

    There is a particular user on this forum who had been proposing fasting as a way of "resetting the receptors". The idea of course being that if you have low levels of a hormone you will experience an increased number of the proteins that the hormone interacts with. I am highly skeptical of this...
    • AretnaP
    • Thread
    • androgens fasting testosterone
    • Replies: 301
    • Forum: Male Issues
  8. haidut

    PUFA And MUFA Are Strong Inhibitors Of 5-AR, Saturated Fatty Acids Are Not

    I have posted quite a few studies showing the effects of various fatty acids on estrogen, androgen and glucocorticoid synthesis. This study shows that both PUFA and MUFA are strong inhbitors of 5-AR, with PUFA being the more potent inhibitors and inhibition potency being strongly dependent on...
    • haidut
    • Thread
    • 5-alpha reductase androgens dht inhibition inhibitor mufa prostaglandins pufa
    • Replies: 54
    • Forum: Scientific Studies
  9. haidut

    A List Of Androgens That Stimulate 5-AR Activity

    Increasing 5-AR activity has received a lot of interest lately due to its therapeutic effects on mood disorders as well as issues with excess cortisol (5-AR deactivates cortisol). Unfortunately, the official story is that there are no freely available compounds that can stimulate 5-AR activity...
    • haidut
    • Thread
    • 5-alpha reductase androgens androstanediol androstenedione androsterone dht enhance induce promote stimulate testosterone
    • Replies: 83
    • Forum: Scientific Studies
  10. haidut

    Androgens (androsterone/DHEA/T) Are Calcium Channel Blockers / Antagonists

    The study found that all tested androgens, as well as progesterone were calcium channel blockers and 5b-DHT was the most potent. Androsterons was next, and it was equipotent to DHEA and testosterone. While the dose used in the study was high, the authors believe that the same effects may be...
    • haidut
    • Thread
    • androgens androsterone calcium antagonist calcium blocker calcium channel cvd hrt prevention
    • Replies: 9
    • Forum: Scientific Studies
  11. haidut

    The Thyromimetic Mechanism Of Androsterone (and Other Androgens)

    As I posted in one of the androsterone threads, studies in the first half of the 20th century discovered hypocholesteremic and pyrogenic effects of androsterone and many animal models and also in humans. However, the direct mechanism for these effects of androsterone was not elucidated by these...
    • haidut
    • Thread
    • androgens androsterone cholesterol estrogen thiouracil thyroglobulin thyroid thyromimetic thyroxine
    • Replies: 28
    • Forum: Scientific Studies
  12. Drareg

    SHBG Gene Promoter Polymorphisms In Men Are Associated With Serum Sex Hormone-binding Globulin, Andr

    This interesting in relation to the femur bone growth. SHBG gene promoter polymorphisms in men are associated with serum sex hormone-binding globulin, androgen and androgen metabolite levels, and hip bone mineral density. Abstract CONTEXT: SHBG regulates free sex steroid levels, which in...
  13. Drareg

    SHBG, Plasma, And Urinary Androgens In Weight Lifters After A Strength Training

    "Previous studies with different results have suggested that total and bioavailable testosterone levels are modified by physical exercise. Such changes may be related to modifications in cortisol levels and could be reflected in some urine androgens. To determine how weight lifting training may...
  14. haidut

    Raising Serum Androgens Using DHEA, Pregnenolone, And Vitamin K

    User testimony (4/26/2021): My Experiences With Raising Androgens Log (Pansterone, k2, magnoil) Many people use supplements like DHEA, pregnenolone, and progesterone with the goal of raising their androgens and lowering estrogen. While this approach works for raising tissue levels of steroids...
    • haidut
    • Thread
    • androgens androstenedione aromatase dhea dht gonads hypogonadism menaquinone pregnenolone serum steroidogenesis synthesis testosterone vitamin k vitamin k2
    • Replies: 444
    • Forum: Scientific Studies
  15. haidut

    Pineal Gland Chemicals Inhibit Androgen Synthesis

    There is great interest in the blogosophere in writing about and supplementing with the pineal hormone melatonin. Ray has written about the dangers of melatonin, but there is enough contradictory research to confuse people. This study shows that another pineal hormone, which ALWAYS rises...
    • haidut
    • Thread
    • androgens hormone inhibition melatonin methoxytryptamine mtn pineal steroid study
    • Replies: 2
    • Forum: Scientific Studies
  16. haidut

    Demyelinating Conditions Like MS Can Be Treated By Androgens

    Ray wrote quite a bit on the topic of estrogen as a causative factor in demyelination and progesterone / pregnenolone as remyelinating agents. I posted an animal study recently on using DHT to completely reverse the pathology of the MS that model...
    • haidut
    • Thread
    • androgen receptor androgens dht multiple sclerosis physiological remyelination reversal study testosterone treatment
    • Replies: 6
    • Forum: Scientific Studies
  17. haidut

    Androsterone - The Legal Pro-hormone For Potent 5-AR Derived Androgens

    Adnrosterone is a downstream metabolite of DHT and just like DHT it is a 5-AR derived steroid. What is even more interesting is that androsterone is not just a metabolite of DHT but can be converted back to DHT as needed in target tissues where DHT is needed. In fact, androsterone has at least 2...
    • haidut
    • Thread
    • 5-alpha reductase androgens androsterone dht prohormone
    • Replies: 10
    • Forum: Scientific Studies
  18. haidut

    Multiple Sclerosis (MS) Can Be Caused Quite Easily By Change In Hormones

    If you ask a neurologist she/he will tell you that nobody knows the cause of MS, and if you ask about the role of hormones the doctor will probably give you blank stare and flatly deny that they have a causative or therapeutic role (except for cortisol as acute treatment). Ray, on the other...
  19. haidut

    DHEA (and Other Androgens) Deplete EFA (PUFA) And Increase SFA

    A human study and as such very relevant. The dose of DHEA used was high (200mg), but androgens derived from DHEA have the same (and even more potent) effects in much lower doses, so low-dose DHEA should have similar (if not even better) effect. Yet another indication that androgens are...
    • haidut
    • Thread
    • androgens cholesterol dhea efa efa deficiency pufa reduction study
    • Replies: 10
    • Forum: Scientific Studies
  20. haidut

    Acne Is Likely Caused By Estrogen, NOT Androgens

    Ray wrote several times that acne and its occurrence in "syndromes" like PCOS is an estrogen-driven phenomenon. However, the medical profession is firmly holding onto its dear idea that it is androgens like DHT, DHEA, T, and androsterone that are causing the acne and the insulin resistance in...
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