1. haidut

    Fasting/exercise/lowcarb/keto may promote cancer (melanoma) metastasis

    Quite the title for this post, but I think the evidence from the study below is clear. Namely, chronic activation of the so-called "master metabolic sensor" AMPK is a key mechanism through which melanoma cells rewire their metabolism from higher into lower OXPHOS, change their physical structure...
  2. Limon9

    Coffee Diterpenes Have A Metformin-Like Anti-Diabetic Action

    My previous post highlighted the pathological mTOR-mediated aerobic glycolysis caused by endotoxin, so I thought it should be balanced with an example of glycolysis-boosting when oxidative phosphorylation is unimpaired. The experiment looked both in vitro and in vivo at the effects of kahweol, a...
  3. haidut

    Fasting causes aging by energy depletion, vitamin B2 can stop it

    Well, if this title does not rile up the fasting crowd, I don't know what will:-) Aside from that controversy, it is actually a great study that not only suggests a dirt cheap and widely available option for retarding aging, but once again demonstrates that stress (e.g. fasting) directly causes...
  4. Mauritio

    Aspirin Activates AMPK ,reduces Liver Fat

    Aspirin: New evidence is helping explain additional health benefits and open potential for new uses This Studie found aspirin activates AMPK ,which is called the master regulator of metabolism . It is involved in mitochondrial biogenesis, weight loss etc... They also found that aspirin reduces...
  5. haidut

    Aspirin Is A Janus Kinase (JK) Inhibitor

    The so-called JK inhibitor drugs are all the rage right now for a number of chronic inflammatory conditions including IBD, RA, Lupus, MS, cancer and Alzheimer. This study found that aspirin (salicylic acid) is a potent JK inhibitor and as such relevant for all the conditions mentioned above. Not...
  6. P

    Biotin Decreases Serum Free Fatty Acids

    Effects of Biotin Supplementation in the Diet on Adipose Tissue cGMP Concentrations, AMPK Activation, Lipolysis, and Serum-Free Fatty Acid Levels. - PubMed - NCBI Several studies have shown that pharmacological concentrations of biotin decrease hyperlipidemia. The molecular mechanisms by which...
  7. P

    Regulation Of The Energy Sensor AMP-activated Protein Kinase In The Kidney By Dietary Salt Intake An

    Regulation of the energy sensor AMP-activated protein kinase in the kidney by dietary salt intake and osmolality. - PubMed - NCBI Abstract The AMP-activated protein kinase (AMPK) is a key controller of cellular energy metabolism. We studied its expression and regulation by salt handling in...
  8. P

    Maintenance Of Red Blood Cell Integrity By AMP-activated Protein Kinase α1 Catalytic Subunit Abstract AMP-activated protein kinase (AMPK) plays a pivotal role in regulating cellular energy metabolism. We previously showed that AMPKα1−/− mice develop moderate anemia associated with splenomegaly and high reticulocytosis...
  9. haidut

    Methylene Blue (MB) Reverses Fatty Liver Disease

    This study was in mice, but the results were so positive that the authors are working in setting up a clinical trial of methylene blue for the treatment of fatty liver disease - a condition that afflicts approximately 40%-60% of the population in the USA. Many Peatarians also struggle with poor...
  10. N

    15 Aspirins Per Day?
Top Bottom