alzheimer's

  1. haidut

    Pregnenolone Is A Potent (functional) Endotoxin (TLR4) Antagonist

    It seems that pregnenolone is finally starting to look exciting to the medical industry. In addition for its intensive studies for a variety of mental issues, now studies are coming out demonstrating its endotoxin (LPS) antagonism effects. As most forum users know, endotoxin exerts its effects...
  2. haidut

    Increased Cholesterol Esterification As A Cause Of Alzheimer Disease (AD)

    Peat's most recent newsletter was on the topic of cholesterol and its increased esterification as a possible cause of the many pathologies that occur with aging. Nov 2018: Dr. Peat Talks About Cholesterol Esters Causing Aging One of the organs most vulnerable to cholesterol esterification is...
  3. haidut

    Stress And Learned Helplessness May Be The Main Cause Of Dementia

    A great study showing that controlling for factors such as sex, marital status, lower educational level, lifestyle factors, existing chronic and acute disease, substance abuse, etc did NOT change dementia risk. The only thing that correlated (likely causatively) with risk of dementia (e.g...
  4. haidut

    Periodontal Disease Can Cause Alzheimer's Disease (AD)

    Peat has written many times on the link between periodontal disease, and endotoxin. He mentioned how a few dentists he knows stopped doing dental cleaning after they found that that giving their patients laxatives or antibiotics cured their gum disease. In addition, a few studies came out...
  5. haidut

    Bile Acid Stimulates Mitochondrial Function, Could Treat Parkinson And Alzheimer's

    I posted a few studied some time ago showing that bile acids increase metabolism but stimulating the synthesis of T3. This increase in metabolism is perhaps the main mechanism behind the ability of "obesity surgery" to provide long-term benefits for the people who undergo the procedure. Aside...
  6. haidut

    Canola Oil (PUFA) Causes Obesity, Memory Impairment, And Likely Alzheimer Disease (AD)

    I really like this study because it is one of the few that examine the direct effects of adding PUFA to the diet. As such, it serves to expose the fraudulent "science" that led to the replacement of healthier oils (like beef tallow, butter, olive oil) in the Western diet with the cheap...
  7. haidut

    Another Human Study Shows Methylene Blue (MB) May Treat Alzheimer Disease (AD) If Used On Its Own

    A few months ago, a thread was posted about the news published by mainstream media that MB "failed" in a human trial for AD. It only failed when it was combined with other drugs currently used for AD, as those drugs are mostly cholinergic and highly excitotxic. When used on its own, MB showed...
  8. haidut

    Niacinamide And Doxycycline May Treat Alzheimer Disease (AD)

    This study is yet another one that shows benefit of raising NAD levels for treating neurodegenerative conditions like AD. There were a few older studies around 2003, which were also done on mice and as a result of those studies a human clinical trial with 3g niacinamide daily (a dose that...
  9. haidut

    Human Study Confirms Alzheimer As A Metabolic Condition (brain Diabetes)

    Over the last 3 years I posted quite a few studies on Alzheimer disease (AD) and have discussed it at length in the Danny Roddy podcasts. Among the most successful interventions are niacinamide and methylene blue (MB) both of which are in human clinical trials, thyroid and aspirin. Alzheimer...
  10. haidut

    Lanosterol - Liquid Lanosterol For Lab/R&D

    I guess most people on the forum who have heard of lanosterol know it in the context of treating cataracts. Lanosterol - Wikipedia There is a company out there who used to sell lanosterol as eye drops and it is insanely expensive - $100 for a meager 10mg lanosterol. Anyways, lanosterol is...
  11. haidut

    Higher Serotonin Availability May Be The Cause Of Cognitive Impairment / Dementia

    Some of you may have seen this study in the news lately. However, it is being presented as the exact opposite as what my title says. The media titles all over the Internet proclaim that "John Hopkins study shows low serotonin causes dementia". However, if you look at the actual study you will...
  12. haidut

    Iron Overload Linked To Alzheimer Disease (AD)

    I posted a few recent studies that finally start to make the connection between endotoxin, iron, and neurodegenerative conditions. Endotoxin And Iron Finally Recognized As Potential Causes Of Many Diseases Endotoxin (LPS) May Be A Causative Factor In Alzheimer Disease (AD) Big Pharma is...
  13. haidut

    Estrogen Impairs Memory In Women

    There has been some evidence from rodent studies that estrogen and BDNF are antagonistic to each other as animals exposed to estrogen cannot remember very well. BDNF is akin to an anabolic steroid for the brain, and estrogen powerfully impairs its effects, especially in cases of traumatic brain...
  14. haidut

    Alzheimer Disease (AD) May Be Simply Diabetes Of The Brain

    I touched upon this topic in one of the Danny Roddy shows we did last year but the evidence since then has continues to accumulate that AD is entirely a metabolic disorders, basically identical to diabetes but focusing on the brain. A recent study found that delirium, an acute form of...
  15. haidut

    Death Rate From Alzheimer Disease (AD) Has Risen By 55% In Just 5 Years

    I am surprised this dire statistic even made it to front page news, but hopefully it would give the public some food for thought. The even scarier news buried inside this tragic article is that most of the deaths are due to the so-called "early onset" AD, which strikes people in their 50s, 60s...
  16. haidut

    Delirium (and Dementia/AD) Is Caused By Inability To Oxidize Glucose

    Ray has written about the metabolic origins of Alzheimer disease (AD) and I posted quite a few studies on the links between AD and PUFA metabolites as well as insulin resistance in the brain. I even mentioned on one of Danny Roddy's shows that there is a proposal by NIH to reclassify AD as...
  17. Mito

    Flickering Lights Treat Alzheimer's?

    http://www.nature.com/nature/journal/v540/n7632/full/nature20587.html Changes in gamma oscillations (20–50 Hz) have been observed in several neurological disorders. However, the relationship between gamma oscillations and cellular pathologies is unclear. Here we show reduced, behaviourally...
  18. haidut

    Another Study Links PUFA To Alzheimer Disease (AD)

    I posted some studies a few months ago, which showed that PUFA metabolites are elevated in patients with AD, and that blocking PUFA metabolism can reverse the pathology (in an animal model). Increased Pufa Oxidation May Be Biomarker For Alzheimers Blocking PUFA Metabolism May Reverse Alzheimer...
  19. haidut

    Caffeine Protects Against Dementia (AD), ALS, Parkinson, And Huntington Disease

    The link between caffeine intake and lower risk of neurodegenerative conditions has been established before but the mechanism of action was unknown. This study discovered one possible mechanism and also confirmed the associative findings in vivo using a mouse model. The HED was 150mg - 300mg...
  20. haidut

    Glucose Deprivation In The Brain Is A Causative Factor In Alzheimer's Dieases (AD)

    As the study says, whether lower glucose levels in the brain were the consequence or cause of AD was considered unknown until recently. This is one of the studies that established a causal link between lower blood glucose levels in the brain and the development AD. I wonder if we are going to...
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