1. haidut

    Androsterone Is A Potent Agonist / Activator Of The Farnesoid X Receptor (FXR)

    The so-called Farnesoid X Receptor (FXR) is a very interesting nuclear receptor inside the cell. It has a multitude of functions, but one of the main functions includes sensing and controlling the levels and synthesis of bile acids. As I mentioned in a few other posts, nuclear receptors...
  2. haidut

    Androsterone - Anxiolytic, Sedative, And Anti-Convulsant Neurosteroid

    I just posted a thread about androsterone and its potent anti-depressant effects: Androsterone - An Andidepressant Neurosteroid Just like allopregannolone (ALLO), androsterone is 5-AR derived neurosteroid, and just like allopreganolone androsterone is a very potent GABA agonist (even more...
  3. haidut

    Pregnenolone Activates The Glycine Receptor

    This mechanism of pregnenolone is one of the proposed methods through which it enhances neurogenesis, memory, mood and even motor function. Low doses pregnenolon improve sleep quality and are even mildly sedating, which may also be due to the activation of the glycine receptor. Subunit-specific...
  4. haidut

    Anti-serotonin, Pro-dopamine Drug Approved For Psychosis And Bipolar Disease

    After more than 5 decades of claiming that psychosis conditions like schizophrenia are caused by excessive dopaminergic activity and depression is a deficiency of serotonin, big pharma is doing 180 degrees reversal. A new drug was just approved for treating bipolar disorder and schizophrenia in...
  5. haidut

    Caffeine is a (functional) dopamine "agonist"

    I just rediscovered this going through my old emails I exchanged with some Russian scientists. This seems to explain some of the effects of caffeine on temperature and memory. ... ne&f=false "...It is well described that adenosine receptor agonists...