aging

  1. P

    Aging As A Consequence Of Intracellular Water Volume And Density

    Aging as a consequence of intracellular water volume and density - ScienceDirect Aging as a consequence of intracellular water volume and density Author links open overlay panelDiegoBonattoaBruno CésarFeltesbJoice de FariaPolonib RedirectingGet rights and content Open Access funded by...
  2. haidut

    Naked Mole Rats Do Not Age

    Many forum users are familiar with the naked mole rat. Peat has mentioned them a few times and we have a few other posts about them on the forum. They are highly resistant to cancer, and while the mainstream medical view is that this is due to their special genes the much more likely explanation...
    • haidut
    • Thread
    • aging co2 gomperz gomperz law metabolism naked mole rat resistance
    • Replies: 56
    • Forum: Scientific Studies
  3. haidut

    Niacinamide Retards/Reverses Aging And Physiological Decline

    Yet another study on the beneficial effects of raising NAD levels, and unlike other recent studies this one is not sponsored by ChromaDex. This study used nicotinamide mononucleotide (NMN), and human studies have shown that niacinamide is equally effective as NMN in raising NAD levels. Also, as...
    • haidut
    • Thread
    • aging nad nad+ niacinamide nicotinamide mononucleotide nmn reversal vitamin b3
    • Replies: 32
    • Forum: Scientific Studies
  4. haidut

    Androgen Deficiency As The Main Cause Of Chronic Disease In Males

    This is one of the most comprehensive reviews that I have ever come across on the topic of androgens and their role in male health. It is authored by one of the most renowned experts in urology - the former director of the Department of Urology at Boston University (BU) School of Medicine. Given...
    • haidut
    • Thread
    • aging androgen deficiency androgen deprivation cvd dht diabetes dutasteride finasteride heart attack heart disease hepatocellular carcinoma insulin resistance liver cancer liver disease males mitochondrial dysfunction nafld sexual dysfunction stroke testosterone
    • Replies: 108
    • Forum: Scientific Studies
  5. haidut

    Even A Slight Increase In Estrogen Strongly Decreases DHEA Levels

    I posted a few studies in the past revealing that in old age (and menopause) the levels of pregnenolone, progesterone and DHEA declines, while that of cortisol and aldosterone stays the same or even increases. Pregnenolone, Progesterone And DHEA Drop, Cortisol Rises In Aging The decline in...
    • haidut
    • Thread
    • aging decline dhea dhea-s disease estradiol estrogen frailty menopause
    • Replies: 19
    • Forum: Scientific Studies
  6. P

    Vitamin B3 Modulates Mitochondrial Vulnerability And Prevents Glaucoma In Aged Mice

    Vitamin B3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice. - PubMed - NCBI Glaucomas are neurodegenerative diseases that cause vision loss, especially in the elderly. The mechanisms initiating glaucoma and driving neuronal vulnerability during normal aging are...
  7. haidut

    Ketotifen Prevents Skin Aging/wrinkles Due To UV Light

    Meet your new beauty ingredient - ketotifen. UV light exposure is one of the main triggers of visible signs of skin aging and contributes to lipofuscin formation as well. It looks like ketotifen may be able to prevent that damage and given its leukotriene and histamine antagonism it may be a...
    • haidut
    • Thread
    • aging anti-histamine histamine ketotifen mmp mmp inhibitor prevent reverse skin uv uv light wrinkels
    • Replies: 22
    • Forum: Scientific Studies
  8. haidut

    Lower Growth Hormone (hGH) And IGF-1 Levels In Men Extends Lifespan

    The study is important because it was done on humans and confirms a lot of what Ray has written about the dangers of pituitary hormones, including hGH. Combined with the well-known link between hGH and cancer I am not sure how sane the doctor advising all the athletes juicing with hGH are. The...
    • haidut
    • Thread
    • aging cancer dangerous growth hormone health height hgh longevity
    • Replies: 38
    • Forum: Scientific Studies
  9. haidut

    Stress (from Poverty) Leads To Early Puberty And Health Problems In Adulthood

    I recently posted a study on the effects of pregnancy stress (cortisol) on the development and aging of an organism. Chronic Stress During Pregnancy Accelerates Fetal Aging And Harms Its Health Peat also wrote that virtually all features of aging can be produced by administering a large dose of...
  10. haidut

    Chronic Stress During Pregnancy Accelerates Fetal Aging And Harms Its Health

    Allopathic medicine still denies that maternal stress during pregnancy affects the child's long term health. If anything, they say that the fetus may experience a slightly increased risk of infection during pregnancy but that risk goes back normal as soon as the baby is born. The main argument...
    • haidut
    • Thread
    • aging chronic cortisol crh fetus health pregnancy pregnenolone premature stress
    • Replies: 5
    • Forum: Scientific Studies
  11. Dan W

    Methylene Blue For Skin Health

    A new study (h/t Mike Lustgarten) on methylene blue for skin health: Anti-Aging Potentials of Methylene Blue for Human Skin Longevity
    • Dan W
    • Thread
    • aging anti-aging antioxidant methylene blue ros skin study
    • Replies: 3
    • Forum: Methylene Blue
  12. haidut

    Gilbert Ling's Theory Confirmed - ATP Required For Protein Solubility & Aggregation Control

    As some of you know, the Wikipedia article on Gilbert Ling's AI hypothesis was removed due to being too "alternative" and not accepted as valid by the scientific "consensus". In the mainstream biochemical view, ATP is nothing but an energy currency for cells and has no role in maintaining...
    • haidut
    • Thread
    • aging association-induction hypothesis atp cardinal adsorbent gilbert ling hydrotrope neurodegeneration protein aggregation protein solubility
    • Replies: 31
    • Forum: Scientific Studies
  13. haidut

    The Lower Your Cortisol Levels, The Younger You Look

    Peat has this quote popping up on the forum every once in a while. “The main features of aging can be produced... | Ray Peat Forum "..."...The main features of aging can be produced directly by administering excessive amounts of cortisol. These features include atrophy of skin, arteries, muscle...
    • haidut
    • Thread
    • aging apprearance cortisol epigenetic facial looks perceived youth
    • Replies: 92
    • Forum: Scientific Studies
  14. P

    Brain Insulin Resistance Identified As Possible New Link Between Alzheimer's Disease, Diabetes

    It says brains inability to burn glucose is responsible for Alzheimer's disease.caused by insulin's resistance in brain, and that probably mediated by inflammation. Brain Insulin Resistance Contributes to Cognitive Decline in Alzheimer's Disease – PR News...
  15. P

    DHT Levels Inversely Associated With Insulin Resistance Among Older Men

    Testosterone, Dihydrotestosterone, Sex Hormone Binding Globulin and Incident Diabetes among Older Men: the Cardiovascular Health Study. - PubMed - NCBI Abstract CONTEXT: Although sex hormone binding globulin (SHBG) and testosterone (T) have been inversely associated with risk of diabetes...
  16. haidut

    Aging May Be An Epigenetic Process

    The study focused on turning adult cells into stem cells (which is something yet to be proven safe or replicable in humans), the important message is that aging seems to be an epigenetic process, and as such fully reversible. This matches well with the other studies I posted showing glycine...
  17. haidut

    Pregnenolone, Progesterone And DHEA Drop, Cortisol Rises In Aging

    I posted a few times about the steroidal characteristics of aging. Many people think there is a drop in testosterone (T) in aging and that is what drives the frailty of aging both in men and women. However, numerous studies show that that total T does not decrease with aging. What does seem to...
    • haidut
    • Thread
    • adrenals aging cortisol dhea dht estradiol gonads pregnenolone progesterone steroidogenesis steroids testosterone
    • Replies: 29
    • Forum: Scientific Studies
  18. P

    Relationship Between The Blood Concentration Of Several Metals &Endocrine Disorders Of Aging Males

    Analysis of the relationship between the blood concentration of several metals, macro- and micronutrients and endocrine disorders associated with m... - PubMed - NCBI Abstract Beyond 30 years of age, men experience a decline in the production of testosterone, yet only a few develop late-onset...
    • paymanz
    • Thread
    • aging androgen arsenic cadmium chromium copper estrogen heavy metal iron lead manganese molybdenum selenium shbg testosterone zinc
    • Replies: 1
    • Forum: Articles & Scientific Studies
  19. P

    Spermidine, Found In Cheese And Semen, Extends Lifespan Of Mice And May Work For Humans

    http://www.medicaldaily.com/key-longer-life-spermidine-found-cheese-and-semen-extends-lifespan-mice-and-404464 http://www.nature.com/nm/journal/vaop/ncurrent/full/nm.4222.html Aging is associated with an increased risk of cardiovascular disease and death. Here we show that oral...
  20. haidut

    Carbonic Anhydrase Is A Key Driver Of Aging; Inhibiting It Is Beneficial

    In support of Ray's views of CO2 as one of the main factors in mitochondrial biogenesis and health, and as such in a host of health conditions, this study found that carbonic anhydrase levels are higher and the enzyme itself is more active in both aging and degenerative conditions. Inhibiting...
    • haidut
    • Thread
    • acetazolamide aging antiaging brain cancer carbonic anhydrase carbonic anhydrase inhibitor co2 dementia neurodegeneration pathological thiamine vitamin b7
    • Replies: 39
    • Forum: Scientific Studies
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