aging

  1. haidut

    Aging is an energy deficiency problem, taking cardiolipin may reverse it

    Yet another study demonstrating that "aging" is nothing but a phenotype characterizing an organism with declining energy production. Since most of the cellular energy is produced in the mitochondria, another way of stating the same is that aging (and any specific disease for that matter) is a...
    • haidut
    • Thread
    • aging cardiolipin disease energy lifespan metabolism mitochondria oxphos
    • Replies: 8
    • Forum: Scientific Studies
  2. haidut

    Inflammation (from PUFA), not telomeres, determines lifespan / healthspan

    The idea of lifespan being entirely determined by limits on cellular division has ruled biology for more than a century and is perhaps best exemplified by the (in)famous (and false) Hayflick limit. Reaching the said limit is postulated to be controlled by telomere length, and as such the...
    • haidut
    • Thread
    • aging aspirin centenarian inflammation lifespan longevity pufa telomere
    • Replies: 0
    • Forum: Scientific Studies
  3. haidut

    Low DHT can cause hypogonadism symptoms even in eugonadal men

    Seemingly contradictory title, but the study findings are pretty clear. Namely, even in males with normal testosterone levels there is a direct inverse relationship between DHT levels and symptoms of hypogonadism such as sexual dysfunction and "aging male" syndrome. For every 10% increase in DHT...
    • haidut
    • Thread
    • aging androgen dht erectile dysfunction eugonadal hypogonadism sexual dysfunction
    • Replies: 1
    • Forum: Scientific Studies
  4. A

    Aging seems to progress in discrete steps - at 34, 60, 78 years

    According to this study which analysed proteins in blood: Stanford scientists reliably predict people’s age by measuring proteins in blood This would strongly point at programmed aging, rather than driven strictly by metabolism, no? As much as I appreciate Ray's work and agree with his methods...
  5. BestSinceDAYONE

    Low carb dieters look so much older

    Is it me or do the low carb gurus look significantly older? Peter Attia, Joe Rogan, Mark Sisson, Gary Taubes, Shawn Baker They all have one thing in common, their faces (and hairlines) look so much worse but they have shredded physiques.
  6. haidut

    Blocking PUFA/prostaglandins restores metabolism and reverses brain aging

    The bad news for PUFA has been accumulating for decades, yet public health authorities continue to claim that type of fat is "essential". Whatever indirect admissions of the pathological role of PUFA in both chronic and acute/infectious diseases is given to the public, is usually confined to the...
    • haidut
    • Thread
    • aging aspirin brain glucose inflammation metabolism prostaglandins pufa
    • Replies: 5
    • Forum: Scientific Studies
  7. cupofcoffee

    Caffeine promotes the expression of telomerase reverse transcriptase to regulate cellular senescence and aging

    https://pubs.rsc.org/en/content/articlelanding/2021/FO/D0FO03246H#!divAbstract
    • cupofcoffee
    • Thread
    • aging caffeine coffee liver spleen telomerase telomeres thymus
    • Replies: 16
    • Forum: Coffee
  8. P

    55 year-old looks like 25

    Interesting video about a 55 year-old photographer who looks like an elite 25 year-old fitness model. He's 55 Years Old But Looks 25... Reacting To Chuando Tan Reveal His Secrets Summary: He looks the same as he did in the late 1980s, in his 20s. He doesn't drink or smoke, doesn't drink coffee...
  9. llian

    Reverse aging

    Hi! Fairly new to this forum Can somebody correct/add anything else to my guide that i made and infos that i gathered for a while?? This is it: • Lifestyle: ⚠️no stres, smoking, drinking, drugs, too much sun⚠️ 》Wim Hof breathing / Buteyko Method 》Meditation 》3x/week sprint. 3x/week running...
  10. haidut

    Low energy production (glucose metabolism) may cause andropause

    As many of my readers know, aging men can also experience the equivalent of menopause and doctors informally call that state "andropause". Its official name is age-related hypogonadism and most of that hypogonadism is of the "secondary" type - i.e. the gonads appears to be in fine shape but for...
    • haidut
    • Thread
    • aging andropause energy glucose hypogonadism metabolism steroidogenesis testosterone
    • Replies: 0
    • Forum: Scientific Studies
  11. Mauritio

    Drug Reverses Age-Related Mental Decline Within Days

    Drug Reverses Age-Related Mental Decline Within Days ...and what the drug does is , simply blocking the integrated stress response ! This article is a good read . The researchers seem pretty legit , although I'm sure they dont know about RP ,but they do look at inflammation and cellular health...
  12. haidut

    The Cure For Aging Might Be The Cure For Alzheimer’s

    Almost 25 years ago, Dr. Peat himself wrote a 2-article series in which he outlined arguments in favor of the hypothesis that aging and Alzheimer Disease (AD) are just examples of a more and less systemic sign respectively of declining energy production, and that curing one would lead to a cure...
    • haidut
    • Thread
    • aging alzheimer cure disease energy immortality metabolism
    • Replies: 3
    • Forum: Scientific Studies
  13. haidut

    Policosanol Is Antiviral And A Potent Inducer Of Anti-aging Gene Klotho

    This post is a good complement to the recent ones I did on androgens, estrogens and their opposing effects on the expression of the anti-aging gene Klotho. While I was doing research on that gene, I had a "random" thought pop up in my mind. It is well-known that some Caribbean countries have a...
    • haidut
    • Thread
    • aging anti-aging covid-19 klotho octacosanol policosanol sars-cov-2 sfa
    • Replies: 60
    • Forum: Scientific Studies
  14. haidut

    Androgens Boost, Estrogen Inhibits, Anti-aging Gene Klotho

    This post has two main messages, based on the studies below. Namely, androgens (and especially DHT) potently increase the expression of the anti-aging gene Klotho while estrogens strikingly decrease its expression. Moreover, the more potent the androgen, in terms of androgen receptor (AR)...
    • haidut
    • Thread
    • aging androgen anti-aging dht espression estrogen gene klotho
    • Replies: 2
    • Forum: Scientific Studies
  15. haidut

    Childhood Stress / Deprivation Leads To Early Puberty / Aging

    The evidence that adult health problems have their roots in childhood or even prenatally continues to accumulate. The study below demonstrates that children who have experienced violence, trauma, deprivation or have had generally stressful childhoods not only enter puberty much earlier but are...
    • haidut
    • Thread
    • adversity aging childhood deprivation early puberty stress violence
    • Replies: 5
    • Forum: Scientific Studies
  16. haidut

    Cardiolipin Supplementation May Reverse Signs Of Aging

    One of the key features of aging is the decline in mitochondrial function (metabolism), and that fact is widely recognized even by mainstream medicine. However, doctors still claim that the relationship between metabolic decline and aging has not be elucidated and a causative link cannot be...
    • haidut
    • Thread
    • aging cardiolipin decline metabolism mitochondria phosphatidylcholine reverse
    • Replies: 1
    • Forum: Scientific Studies
  17. haidut

    Aspirin Protects Mitochondria From Inflammation And Aging

    The good news about aspirin just never seem to stop. While the anti-inflammatory effects of aspirin are well-known, mainstream medicine like to explain them away with the limited (and frankly primitive) mechanism of COX inhibition alone. If aspirin happens to achieve some other beneficial health...
    • haidut
    • Thread
    • aging aspirin fission inflammation mitochondria protective salicylate
    • Replies: 9
    • Forum: Scientific Studies
  18. haidut

    "Anti-aging" Hormone (hGH) May Actually Shorten Life

    The duo of hGH/IGF-1 does not need an introduction. Hardly a day passes without some ad on TV promoting the latest and greatest product that "naturally boosts" either hGH or IGF-1 levels. The two hormones have an almost perfect correlation - each one inducing the endogenous synthesis of the...
  19. haidut

    Striking Accumulation Of PUFA In Aged Cells

    Peat has written many times about the changes that occur in "aged" cells. Those changes are virtually indistinguishable from the ones that occur in "sick" cells and are characterized by reduced mitochondrial number/size and a shift in lipid composition away from saturated and towards unsaturated...
    • haidut
    • Thread
    • accumulation age aging cell cellular old pufa senescence
    • Replies: 10
    • Forum: Scientific Studies
  20. md_a

    The Dilemma Of Coronavirus Disease 2019, Aging, And Cardiovascular Disease

    The Dilemma of COVID-19, Aging, and Cardiovascular Disease ....... ACE inhibitors, ARB inhibitors, ARDS Coronavirus is more severe and deadly in the aged, hypertensive, and diabetic. It is also of note that ATR-1 Receptors increase with age and are increased in cancer, diabetes...
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