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  1. C

    11b-HSD1 inhibitors don't lower cortisol levels? increased ACTH response

    a lot of people try to lower cortisol this way. But these studies with a 11b-hsd1 inhibitor given to humans shows plasma cortisol levels stay the same regardless and ACTH levels rise. (ACTH rises in response to the lower conversion of cortisone -> cortisol from the enzyme inhibition, so with...
  2. tastyfood

    Struggling with high ACTH results, am I taking supplements too late in the day?

    I had the highest result of ACTH this week, with 99.1 pg/mL, at 8 in the morning. The reference range for tests in the AM is 7.2-63.3 pg/mL. One of the things I'm evaluating is my consumption of supplements and thyroid towards bed time. Could it be that taking stimulating things before bed...
  3. tastyfood

    Can lower blood cortisol make you excrete more through the urine?

    I've been taking Lisuride and Gonadin for three weeks with the idea of lowering Cortisol levels. I did the 24 urine test again, and my results were higher than the last time. My result this time was 59 ug/24 hours, versus 50 the last time. The top of the lab range is 62. I think that after 50...
  4. P

    Evidence For Brain Sensing Of Circulating FFA

    A Fall in Plasma Free Fatty Acid (FFA) Level Activates the Hypothalamic-Pituitary-Adrenal Axis Independent of Plasma Glucose: Evidence for Brain Sensing of Circulating FFA Endocrinology. 2012 Aug; 153(8): 3587–3592. Published online 2012 Jun 1. doi: 10.1210/en.2012-1330 PMCID: PMC3404348...
  5. haidut

    PUFA Initiate & Promote The Stress Response (ACTH/cortisol), SFA Inhibit It

    Almost two years ago I posted a study showing that PUFA can stimulate cortisol release even in the absence of ACTH. Pufa Stimulates Cortisol Production Even In The Absense Of Acth However, that study above did not look at the effects of saturated fatty acids (SFA) and I keep getting emails...
  6. DaveFoster

    T4 Raises ACTH And Cortisol

    Thyroid hormone action on ACTH secretion. - PubMed - NCBI "Thyroid hormone effects on pituitary ACTH have not been well established. Adult male Sprague-Dawley rats were rendered hypo- and hyperthyroid while undergoing treatment with 6-Propylthiouracil (PTU) and L-Thyroxine (T4). At the time of...
  7. haidut

    Pregnenolone Is The Most Potent Inhibitor Of The Stress Signal (CRH)

    I think this study should finally put to rest the arguments and debates of whether pregnenolone raises or lowers cortisol, and how it affects the stress response overall. I posted a similar study, which showed that the pregnenolone metabolites progesterone and allopregannolone potently inhibited...
  8. haidut

    Pufa Stimulates Cortisol Production Even In The Absense Of Acth

    Many people opposing Peat have complained that there is no evidence for PUFA acting on the stress hormones or that oxidizing PUFA is bad for health. Well, this study not only shows otherwise but also demonstrates that a PUFA metabolite is capable of stimulating cortisol synthesis even in the...
  9. haidut

    Clonidine Lowers Cortisol, ACTH And Overall Stress Response

    It is well known that clonidine lowers adrenalin, and Ray has written about it. It looks like clonidine is also able to restrain the other side of the sympathetic stress response - the ACTH, cortisol, hyperglycemia process. All studies below are in humans. So, it looks like clonidine may be a...