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  1. P

    Progesterone receptors and serotonin levels in colon epithelial cells from females with slow transit constipation (P4 lowers SERT)

    Abstract link to study Background: Females with slow transit constipation (STC) exhibit progesterone receptor (P4R) overexpression in colon muscle that impair their contractility. These studies examined whether these patients have an overexpression of P4R in epithelial cells and...
  2. Mauritio

    Serotonin Depletion Amplifies Distinct Human Social Emotions As A Function Of Individual Differences

    Serotonin depletion amplifies distinct human social emotions as a function of individual differences in personality This study shows that depleting tryptophan, and thus serotonin, allows people more to show their own feelings and individual differences in character . Or saying it reversed ...
  3. Jwicks1995

    Seroquel/Quetiapine - Cortisol/Anti-Seretonin

    I have Unipolar Depression, Anxiety & Major Gut issues. Mirtazapine seems to have failed due to the Noradrenergic profile having a negative effect on my extremely high anxiety. Cannot even handle 15mg it seems...I want to try Seroquel, I understand it affects 5HT1A & antagonizes various 5-HT...
  4. L

    Risk Of Fibrosis With Serotonin Antagonists

    We know that drugs with the 5-ht2b agonist effect have been linked with fibrosis risk. Which of the serotonin antagonists are safe to use for long term in this regard? I have read that cyproheptadine, pizotifen, lisuride, metergoline, ritanserin, ketanserin are safe. Any more?
  5. haidut

    Progesterone, Testosterone, Allopregnanolone Are Serotonin Antagonists

    This study shows that some of the gonadal steroids act in a manner similar to the drug ondansetron - i.e. antagonize the 5-HT3 "receptor". While pregnenolone sulfate was not antagonistic to 5-HT3, taking pregnenolone metabolizes mostly into progesterone and allopregnanolone. So, it seems like a...