12/15lox

  1. NewACC

    High doses of melatonin can FULLY stop pufa peroxidation

    https://pubmed.ncbi.nlm.nih.gov/12074095/ This study says that 1.2mM of melatonin can fully stop peroxidation of long-chain pufa, but only particularly block LOX and COX pufa metabolism. High dose of melatonin with such antiserotonin drug like cypro or just with thyroid is very interesting to...
    • NewACC
    • Thread
    • 12/15lox antioxidant cox-1 cox-2 dose high lipid peroxidation melatonin pufa
    • Replies: 19
    • Forum: Scientific Studies
  2. haidut

    PUFA metabolites may trigger diabetes type I

    Type I diabetes is known as an autoimmune condition. Namely, for some "unknown" reason(s) the beta-cells of the pancreas get attacked by the immune system and over time this leads to their destruction and inability to produce insulin. Of course, no such thing as an "autoimmune" disease exists...
    • haidut
    • Thread
    • 12/15lox beta-cells diabetes inflammation leukotriene lipoxygenase pancreas pufa
    • Replies: 3
    • Forum: Scientific Studies
  3. haidut

    PUFA (metabolites) Drive Heart Failure And Possibly Diabetes

    Over the years I have posted a number of studies on the roles of PUFA metabolites such as prostaglandins and leukotrienes in many chronic conditions including cancer, Alzheimer, Parkinson, ALS, MS, CVD, etc. For those that are new to this issue, COX enzymes are responsible for prostaglandin...
    • haidut
    • Thread
    • 12/15lox alox15 cause cvd diabetes drive fibrosis heart attack heart failure inflammation lipoxygenase lox pufa
    • Replies: 4
    • Forum: Scientific Studies
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